Sakai Hiroyuki

サカイヒロユキ | Sakai Hiroyuki

Affiliation and department：
Job title： Associate Professor,Associate Professor

Research field (3)： Virology , Cell biology , Molecular biology

Research keywords (6)：ヒト免疫不全症ウイルス , がんウイルス , パピローマウイルス , Human immunodeficiency virus , Tumor virus , Papillomavirus

Research theme for competitive and other funds (15)：

2011 - 2013 Understandings of the HPV-induced tumorigenesis for developing anti-virus reagents.
2001 - 2004 Analysis of HPV regulatory gene function with organotypic culture of epithelial cells.
1999 - 2001 Studies on opportunistic oncogenesis in immunodeficient mouse by murine retroviruses.
2000 - 2000 皮膚三次元培養モデルにおけるヒトパピローマウイルス複製機構の解析
1999 - 1999 Functional analysis of HPV genes in keratinocyte organotypic culture system.

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Papers (62)：

Tetsunori Sakamoto, Masahiko Ajiro, Akira Watanabe, Shingo Matsushima, Keiji Ueda, Masatoshi Hagiwara. Application of the CDK9 inhibitor FIT-039 for the treatment of KSHV-associated malignancy. BMC Cancer. 2023. 23. 1
Shingo Matsushima, Masahiko Ajiro, Kei Iida, Kenji Chamoto, Tasuku Honjo, Masatoshi Hagiwara. Chemical induction of splice-neoantigens attenuates tumor growth in a preclinical model of colorectal cancer. Science Translational Medicine. 2022. 14. 673
Ajiro M, Sakai H, Onogi H, Yamamoto M, Sumi E, Sawada T, Nomura T, Kabashima K, Hosoya T, Hagiwara M. CDK9 Inhibitor FIT-039 Suppresses Viral Oncogenes E6 and E7 and Has a Therapeutic Effect on HPV-Induced Neoplasia. Clinical cancer research. 2018. 24. 18. 4518-4528
Bao Ngoc Nguyen, Yukiko Okuno, Masahiko Ajiro, Kei Iida, Masatsugu Denawa, Makoto Yamamoto, Naoya Sakamoto, Hiroyuki Kagechika, Masatoshi Hagiwara. Retinoid derivative Tp80 exhibits anti-hepatitis C virus activity through restoration of GI-GPx expression. Journal of Medical Virology. 2017. 89. 7. 1224-1234
Mika Okamoto, Akemi Hidaka, Masaaki Toyama, Takamitsu Hosoya, Makoto Yamamoto, Masatoshi Hagiwara, Masanori Baba. Selective inhibition of HIV-1 replication by the CDK9 inhibitor FIT-039. Antiviral research. 2015. 123. 1-4

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MISC (61)：

梶谷直子, 酒井博幸. Human papillomavirus(HPV)E1 E4はaggresomeを形成する. 日本ウイルス学会学術集会プログラム・抄録集. 2013. 61st. 345
梶谷直子, 川手章史, 酒井博幸. HPV 18E ^E4 の新規機能の探索. 第60 回日本ウイルス学会学術集会大阪、2012 年11月13日-15日. 2012
梶谷直子, 川手章史, 酒井博幸. HPV 18E1^E4 の新規機能の探索: ビメンチンとの相互作用. 第71 回日本癌学会学術総会、札幌、2012 年9 月19日-21 日. 2012
梶谷直子, 佐塚文乃, 川手章史, 酒井博幸. Identification of a function of Human papillomavirus 18 E1A˄E4. 第70回日本癌学会学術総会, 名古屋, 2011年10月3日-5日. 2011
佐塚文乃, 梶谷直子, 川手章史, 酒井博幸. HPV ゲノムの複製メカニズムの解析. 第70 回日本癌学会学術総会、名古屋、2011 年10 月3 日-5 日. 2011

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Books (3)：

Education (6)：

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Professional career (1)：

Work history (3)：

Association Membership(s) (4)：

日本分子生物学会 , 日本癌学会 , 日本エイズ学会 , 日本ウイルス学会

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