Sakaguchi Kazuyasu

Affiliation and department：
Job title： Professor
Homepage URL (2)： https://wwwchem.sci.hokudai.ac.jp/~biochem/ , http://barato.sci.hokudai.ac.jp/~biochem/

Research field (4)： Biochemistry , Structural biochemistry , Functional biochemistry , Molecular biochemistry

Research keywords (22)： Inhibitor , Enzyme , Differentiation , Cell Cycle , Cancer , Dephospharylation , 翻訳後修飾 , 多量体構造 , ホスファターゼ , p53 , ナノバイオマテリアル , タンパク質科学 , ペプチド科学 , 生物化学 , posttranslational modification , oligomer , phosphatase , p53 , Nanobiomaterial Science , Protein Science , Peptide Science , Biochemistry

Research theme for competitive and other funds (19)：

2023 - 2026 Novel mechanisms in the acquisition of bacterial antibiotics resistance
2023 - 2026 Serious stress resistance mechanism by functional polypeptides encoded by latent ORFs in bacterial ribosomal RNA.
2020 - 2023 Development of a novel genome editing method through transient arrest control of the tumor suppressor protein p53
2019 - 2022 Functional polypeptides encoded by bacterial ribosomal RNA in response to catastrophic stress
2015 - 2016 配位金属制御に基づく新規な基質トラッピング法による癌抑制ホスファターゼ標的の探索

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Papers (138)：

Tatsuya Sakaguchi, Natsumi Nakagawa, Kenta Mine, Jose Isagani B. Janairo, Rui Kamada, James G. Omichinski, Kazuyasu Sakaguchi. Biomineralization through a Symmetry-Controlled Oligomeric Peptide. Biomimetics. 2023. 8. 8. 606-606
Shuya Sakaguchi, Natsumi Nakagawa, Haytham M Wahba, Junya Wada, Rui Kamada, James G Omichinski, Kazuyasu Sakaguchi. Highly Similar Tetramerization Domains from the p53 Protein of Different Mammalian Species Possess Varying Biophysical, Functional and Structural Properties. International journal of molecular sciences. 2023. 24. 23
Rui Kamada, Hiromitsu Miyazaki, Jose Isagani Janairo, Yoshiro Chuman, Kazuyasu Sakaguchi. Bilayer Hydrogel Composed of Elastin-Mimetic Polypeptides as a Bio-Actuator with Bidirectional and Reversible Bending Behaviors. Molecules. 2023
Tatsuki Tsuruoka, Emiri Nakayama, Takuya Endo, Shingo Harashima, Rui Kamada, Kazuyasu Sakaguchi, Toshiaki Imagawa. Development of a fluorescence reporter system to quantify transcriptional activity of endogenous p53 in living cells. Journal of cell science. 2023
Itsumi Tani, Yui Oikawa, Seiyo Doi, Jose Isagani B Janairo, Rui Kamada, Kazuyasu Sakaguchi. Ribosomal protein uL30 undergoes phase separation with nucleophosmin and regulates nucleolar formation in the absence of RNA. Biochemical and biophysical research communications. 2023. 642. 35-40

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MISC (84)：

鎌田瑠泉, 坂口和靖, 尾里啓子. 自然免疫を担うインターフェロン経路における「転写記憶」の発見とその制御機構解明. 実験医学. 2019. 37. 3. 415-418
N. Nakagawa, J. Wada, R. Kamada, T. Nomura, T. Imagawa, K. Sakaguchi. EVOLUTION OF THE TETRAMERIZATION DOMAIN IN TUMOR SUPPRESSOR PROTEIN P53. JOURNAL OF PEPTIDE SCIENCE. 2016. 22. S22-S22
R. Kamada, N. Nakagawa, J. Wada, K. Sakaguchi. ARGININE METHYLATION OF TETRAMERIZATION DOMAIN DESTABILIZES THE TETRAMERIC STRUCTURE OF TUMOR SUPPRESSOR PROTEIN P53. JOURNAL OF PEPTIDE SCIENCE. 2016. 22. S128-S128
Y. Toguchi, M. Kanno, R. Kamada, T. Imagawa, K. Sakaguchi. THE EFFECTS OF P53 TETRAMERIZATION DOMAIN MUTANTS FOUND IN LI-FRAUMENI SYNDROME ON HETERO-OLIGOMER FORMATION AND TRANSCRIPTIONAL ACTIVITY. JOURNAL OF PEPTIDE SCIENCE. 2016. 22. S86-S88
小笠原紗里, 鎌田瑠泉, 坂口和靖. 癌原遺伝子産物プロテインホスファターゼによる細胞癌化機構と阻害剤開発. 化学工業. 2016. 67. 61-66

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Patents (1)：

Methods for Generating Phosphorylation Site-Specific Immunological Reagents

Books (2)：

Peptide Science 2011
The Japanese Peptide Society 2012
自然科学実験
学術図書出版 2007

Professional career (1)：

理学博士 (九州大学)

Committee career (8)：

2013 - 現在日本プロテインホスファターゼ研究会世話人会
2007 - 現在日本ペプチド学会評議員
2022 - 2023 日本生化学会代議員
2018 - 2020 日本ペプチド学会広報担当理事
2014 - 2018 日本ペプチド学会渉外担当理事

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Awards (1)：

2010/10 - 2010 年度(第18 回) JB 論文賞 PPM1D430, a Novel Alternative Splicing Variant of the Human PPM1D, can Dephosphorylate p53 and Exhibits Specific Tissue Expression

Association Membership(s) (10)：

日本プロテインホスファターゼ研究会 , JAPANESE SOCIETY FOR CHEMICAL BIOLOGY , 日本プロテオーム学会 , American Chemical Society , 日本生化学会 , 日本ペプチド学会 , 日本化学会 , Japan Proteome Society , The Japanese Peptide Society , The Chemical Society of Japan

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