Rchr
J-GLOBAL ID：200901073020874800   Update date: Jun. 21, 2024

Kitamura Akira

キタムラ アキラ | Kitamura Akira
Affiliation and department：
Hokkaido University Laboratory of Cellular and Molecular Sciences, Faculty of Advanced Life Science, Division of Functional Life Sciences

About Hokkaido University Laboratory of Cellular and Molecular Sciences, Faculty of Advanced Life Science, Division of Functional Life Sciences


Job title： Senior Lecturer
Research field  (4)： Functional biochemistry ,  Biophysics ,  Molecular biology ,  Cell biology
Research keywords  (13)： Chaperone RNA ,  proteostasis ,  FRAP ,  FRET ,  Fluorescence correlation spectroscopy ,  Polyglutamine disease ,  Amyotrophic lateral sclerosis ,  Proteostasis ,  Fluorescence imaging ,  Neurodegenerative disease ,  Molecular chaperone ,  Protein folding ,  Protein aggregation
Research theme for competitive and other funds  (25)：
  • 2024 - 2029 バイオロジカルクラスター解析のための極限時空間相関分光法の確立
  • 2022 - 2026 細胞内プロテオスタシスを維持するシャペロンRNAの作動機序解明
  • 2022 - 2025 タンパク質2量体安定化機構へ与える細胞内微環境の影響解明
  • 2021 - 2025 神経変性疾患の核酸医薬創薬に向けたシャペロン RNA の実証
  • 2022 - 2024 細胞由来微粒子迅速測定のための蛍光と散乱光測定の融合
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Papers (56)：
  • Akira Kitamura, Ai Fujimoto, Rei Kawashima, Yidan Lyu, Kotetsu Sasaki, Yuta Hamada, Kanami Moriya, Ayumi Kurata, Kazuho Takahashi, Reneé Brielmann, et al. Hetero-oligomerization of TDP-43 carboxy-terminal fragments with cellular proteins contributes to proteotoxicity. Communications Biology. 2024. 7. 1. 743
  • Ai Fujimoto, Haruki Kawai, Rintaro Kawamura, Akira Kitamura. Spike protein of the SARS-CoV-2 omicron variant interacts with actin. bioRxiv (preprint). 2024
  • Takumi Koizumi, Ai Fujimoto, Haruka Kawaguchi, Tsumugi Kurosaki, Akira Kitamura. Stress Granule Dysfunction via Chromophore-Associated Light Inactivation. ACS Omega. 2024
  • Yuzuha Shiraki, Monet Mitsuma, Ritsuko Takada, Saori Hata, Akira Kitamura, Shinji Takada, Masataka Kinjo, Hidenori Taru, Ulrike C Müller, Tohru Yamamoto, et al. Axonal transport of Frizzled5 by Alcadein α-containing vesicles is associated with kinesin-1. Molecular biology of the cell. 2023. 34. 11. ar110
  • Akira Kitamura, Sho Oasa, Haruka Kawaguchi, Misato Osaka, Vladana Vukojević, Masataka Kinjo. Increased intracellular crowding during hyperosmotic stress. Scientific reports. 2023. 13. 1. 11834-11834
ｍore...
MISC (25)：
  • 北村 朗. 蛍光明滅速度変化でRNAの立体構造を識別する. 月刊 光アライアンス. 2023. 34. 8. 8-11
  • 北村朗, 藤本愛. TDP-43タンパク質凝集形成過程におけるシャペロンRNAの役割. Bio Clinica. 2023. 38. 3. 56-59
  • 北村朗, 藤本愛. ALSとFTD関連TDP-43タンパク質凝集形成過程におけるRNAの役割. 月刊「細胞」. 2022. 54. 8. 474-477
  • Akira Kitamura. Realizing RNA roles during protein aggregation associated with neurodegenerative diseases. The CELL. 2021. 53. 9. 578-581
  • Akira Kitamura, Ai Fujimoto. Protein aggregations and their gene therapy in neurodegenerative disorders. Bio Clinica. 2021. 36. 5. 453-456
ｍore...
Patents (2)：
  • TDP43、TDP35、またはTDP25の凝集を特徴とする神経変性疾患の治療剤、進行抑制剤、および予防剤
  • ヘモシアニン会合体を用いた包摂体の製造方法
Books (1)：
  • 新・生細胞蛍光イメージング
    共立出版 2015
Lectures and oral presentations  (31)：
  • Molecular cell biology through induction, kinetic analysis, and inactivation of biomolecules using ultimate light technology
    (MBSJ2023 2023)
  • Detective tools of RNA structural transition using fluorescence blinking
    (45th MBSJ annual meeting 2022)
  • Diffusion coefficient measurement using fluorescence recovery after photobleaching -a homework during summer vacation with refreshment-
    (60th BSJ annual meeting 2022)
  • Basics and applications of chromophore-assisted light inactivation (CALI)
    (60th BSJ annual meeting 2022)
  • Intracellular structure and function of chaperone RNA
    (International Workshop on Fluorescence Methods and Applications 2022 2022)
ｍore...
Education (5)：
  • - 2008 Kyoto University Graduate School of Science Division of Biological Sciences
  • - 2008 Kyoto University Graduate School, Division of Natural Science
  • - 2005 Kyoto University Graduate School of Science Division of Biological Sciences
  • - 2003 Kyoto University Faculty of Engineering School of Industrial Chemistry
  • - 2003 Kyoto University Faculty of Engineering
Professional career (1)：
  • Ph.D. (Kyoto University)
Work history (12)：
  • 2023/08 - 現在 RIKEN Center for Biosystems Dynamics Research Visiting Researcher
  • 2023/08 - 現在 Hokkaido University Faculty of Advanced Life Science Senior Lecturer (Tenure and PI)
  • 2022/10 - 現在 PRIME, AMED
  • 2019/10 - 現在 Hokkaido University Research and Education Center for Brain Science
  • 2019/04 - 2023/07 Hokkaido University Faculty of Advanced Life Science Senior Lecturer (Tenure-track)
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Committee career (9)：
  • 2024/02 - 現在 Frontiers in Biophysics Review editor
  • 2024/01 - 現在 Biophysics and Physicobiology (BPPB) Editorial Board Members
  • 2023 - 現在 Spectroscopy Journal Editorial Board Members
  • 2018/01 - 現在 日本生物物理学会 分野別専門委員(神経変性疾患分野)
  • 2009 - 現在 光イメージング若手の会「光塾」 総括塾員
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Awards (1)：
  • 2022/09 - The biophysical Society of Japan 2022 Biophysics and Physicobiology (BPPB) Awards
Association Membership(s) (4)：
JAPAN SOCIETY FOR CELL BIOLOGY ,  THE BIOPHYSICAL SOCIETY OF JAPAN ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  The RNA Society of Japan
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