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J-GLOBAL ID：200901073364691764 Update date: Apr. 07, 2025

Sugasawa Kaoru

スガサワカオル | Sugasawa Kaoru

Affiliation and department：
Job title： Professor

Research field (4)： Molecular biology , Genetics , Environmental effects of chemicals , Environmental effects of radiation

Research keywords (3)： cancer , xeroderma pigmentosum , DNA repair

Research theme for competitive and other funds (36)：

2021 - 2025 Studies on the principles of chromatin functions ensuring the repair of DNA damage induced by environmental stresses
2016 - 2021 ヌクレオチド除去修復におけるゲノムDNA損傷認識の高次制御機構の解明
2016 - 2018 クロマチン動構造を介したDNA損傷修復制御の分子基盤
2017 - 色素性乾皮症治療薬の探索
2011 - 2016 Crosstalk of transcriptional control and energy pathways by hub metabolites

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Papers (148)：

Tomoya Hotani, Motonari Goto, Yukie Otsuki, Shun Matsuda, Nobuhiro Wada, Masakazu Shinohara, Tomonari Matsuda, Masayuki Yokoi, Kaoru Sugasawa, Yuki Ohsaki, et al. Dynamics of Fanconi anemia protein D2 in association with nuclear lipid droplet formation. 2025
日下部将, 菅澤薫. ヌクレオチド除去修復のDNA損傷認識を制御するクロマチンダイナミクス. 生化学. 2025. 97. 1. 61-65
Satoshi Ninagawa, Masaki Matsuo, Deng Ying, Shuichiro Oshita, Shinya Aso, Kazutoshi Matsushita, Mai Taniguchi, Akane Fueki, Moe Yamashiro, Kaoru Sugasawa, et al. UGGT1-mediated reglucosylation of N-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins. eLife. 2024. 12
Takeshi Yasuda, Nakako Nakajima, Tomoo Ogi, Tomoko Yanaka, Izumi Tanaka, Takaya Gotoh, Wataru Kagawa, Kaoru Sugasawa, Katsushi Tajima. Heavy water inhibits DNA double-strand break repairs and disturbs cellular transcription, presumably via quantum-level mechanisms of kinetic isotope effects on hydrolytic enzyme reactions. PLOS ONE. 2024
Takeshi Yasuda, Nakako Nakajima, Tomoko Yanaka, Takaya Gotoh, Wataru Kagawa, Kaoru Sugasawa, Katsushi Tajima. Cell viability is dominated by quantum effects. 2023

MISC (78)：

黛結衣子, 高藤賢, 中谷一真, 菅澤薫, 浦聖恵, 佐々彰. Investigating the TDP1-mediated error-prone repair of a ribonucleotide embedded into the genome. 日本環境変異原ゲノム学会大会プログラム・要旨集. 2021. 50th
高藤賢, 立川明日香, 黛結衣子, 中谷一真, 菅澤薫, 浦聖恵, 佐々彰. Molecular mechanism of excessive immune response caused by aberrant DNA repair. 日本環境変異原ゲノム学会大会プログラム・要旨集. 2021. 50th
竹石歩奈, 古樫浩之, 小田切瑞基, 笹沼博之, 武田俊一, 安井学, 本間正充, 菅澤薫, 浦聖恵, 佐々彰. Tyrosyl-DNA phosphodiesterasesはDNA中のリボヌクレオチドを起因とする突然変異形成に関与する. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
SUGASAWA KAORU. Molecular mechanism of DNA damage recognition for global genomic nucleotide excision repair: A defense system against UV-induced skin cancer. DNA Repair Disorders. 2019. 1-23
Chikako Nishigori, Kaoru Sugasawa. DNA repair disorders. DNA Repair Disorders. 2018. 1-221

Patents (1)：

Books (5)：

紫外線によるDNAの損傷とがん化のメカニズム
技術情報協会 2016
DNA Replication, Recombination and Repair: Molecular Mechanisms and Pathology
Springer 2016
光老化科学の最前線
シーエムシー出版 2015
DNA Repair (Kruman, I. ed.)
InTech 2007
DNA Repair disorders
Springer ISBN:9789811067211

Lectures and oral presentations (319)：

DNA の構造的要因から探るヌクレオチド除去修復制御機構
(第42回染色体ワークショップ・第23回核ダイナミクス研究会 2025)
脂肪族アルデヒドの代謝異常がゲノム安定性に及ぼす影響
(日本環境変異原ゲノム学会第53回大会 2024)
CRL4Cdt2のDNA合成部位への適切な集積と解離が細胞周期進行を制御する
(第47回日本分子生物学会年会 2024)
クライオ電子顕微鏡によるクロマチン上の紫外線損傷修復メカニズムの解明
(第47回日本分子生物学会年会 2024)
ヌクレオチド除去修復のDNA損傷認識制御におけるヒストン修飾の役割
(第47回日本分子生物学会年会 2024)

Education (1)：

- 1989 The University of Tokyo Graduate School of Pharmaceutical Science Doctoral Program

Professional career (2)：

Association Membership(s) (8)：

THE JAPANESE ENVIRONMENTAL MUTAGEN SOCIETY , THE JAPANESE RADIATION RESEARCH SOCIETY , 日本遺伝学会 , 日本癌学会 , 日本細胞生物学会 , 日本薬学会 , 日本生化学会 , 日本分子生物学会

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