
	Chemical structure search How to Search	Import MOLfile format is only available (V3000 format is not available) Exact match Substructure search Superstructure search Substructure or superstructure search Similarity search

Details
Related links
Search

Co-authoring Researcher

IKEMURA Kenji
Osaka University
薬物動態学, 医療薬学
Muraki Yuichi
Kyoto Pharmaceutical University Hospital
Enokiya Tomoyuki
Suzuka University of Medical Science Faculty of Pharmaceutical Sciences
Biomedical Informatics, Pharmacoinfomatics, Clinical pharmacokinetics, Clinical Statistical Analysis, Clinical Pharmacology, Clinical Toxicology, Infectious Disease, Critical Care Pharmacy, Thrombomodulin, Disseminated Intravascular Coagulation

Co-inventing Researcher

Researcher similar to the Researcher

Article similar to the Researcher

Patent similar to the Researcher

Research Project similar to the Researcher

Article(J-GLOBAL estimation)

Patent(J-GLOBAL estimation)

Rchr

J-GLOBAL ID：200901073924174116 Update date: Jan. 22, 2025

Okuda Masahiro

オクダマサヒロ | Okuda Masahiro

Clips

Affiliation and department：
Job title： Professor and Director
Homepage URL (1)： http://www.med.osaka-u.ac.jp/pub/hp-drug/

Research field (3)： Clinical pharmacy , Pharmacology , Pharmaceuticals - health and biochemistry

Research keywords (10)：オーダーメイド薬物療法 , 薬物トランスポータ , 薬物動態学 , 薬剤学 , 医療薬学 , Tailored Therapeutics , Drug Transporter , Pharmacokinetics , Pharmaceutics , Clinical pharmacy

Research theme for competitive and other funds (37)：

2023 - 2026 Development of novel prevention for cancer chemotherapy-induced peripheral neuropathy using multi-layered approach
2022 - 2025 非劣性的検討による地域フォーミュラリ導入の患者アウトカム評価
2021 - 2024 Development of prevention for cisplatin-induced ototoxicity based on analysis of clinical big data
2020 - 2023 Development of prevention for ciplatin-induced nephrotoxicity using clinical real-world data
2017 - 2020 Analysis on the expression of protein regulating pharmacokinetics via oxidative stress-response lncRNA

2017 - 2020 Development of novel preventive method for cisplatin-induced nephrotoxicity with drug-drug interaction

2017 - 2019 Development of novel pharmacotherapy by thrombomodulin-alfa for severe infection and DIC

2016 - 2019 Construction of PK/PD evaluation system for optimizing treatment using immune checkpoint inhibitors

2015 - 2018 Development and evaluation of protocol-based pharmacotherapy management of HIV outpatients based on drug bood concentration

2014 - 2017 Role of microRNA on the pharmacokinetics and pharmacodynamics of tacrolimus in inflammatory bowel disease

2014 - 2017 Role of microRNA on the pharmacokinetics of calcineurin inhibitors after living liver transplantation

2012 - 2015 Risk evaluation of carboplatin-induced allergy based on basophil activation test and FceRI expression.

2011 - 2013 Regulation of functions of drug transporters in renal tubules by inflammatory cytokines and implication of its significance

2010 - 2011 Basic research for the prevention of cisplatin-induced renal toxicity based on the characteristics of renal tubular transport of its cytotoxic metabolite

2008 - 2010 Expression and functions of drug transporters in renal tubules by kidney-specific oxidative stress and its role

2008 - 2009 血中ホモシステイン測定によるロイコボリン投与スケジュールの個別化に関する研究

2006 - 2007 Basic construction of individual administering design method based on clarification of excretion mechanism of topoisomerase I inhibitor

2005 - 2006 Evaluation and estimation of renal drug elimination based on promoter analyses of organic cation transporters

2003 - 2004 Elucidation of gene expression mechanisms of kidney-specific organic cation transporter OCT2 by promoter analyses.

2002 - 2003 薬物トランスポータの発現量変動評価系の構築-薬物体内動態制御薬の開発へ向けて

2001 - 2003 Evaluation of drug interaction and interindividual differences of renal drug excretion based on the genetic polymorphism analysis

1997 - 1999 Development of novel systems for evaluation and prediction of drug inteactions based on the reconstruction of drug excretion systems in vitro.

1998 - 1998 薬剤性腎障害におけるアポトーシス誘動と腎障害発現防御に関する研究

1998 - 1998 薬物トランスポータの分子認識能を利用した臓器特異的薬物送達システムの構築

1997 - 1998 有機カチオントランスポータのクローニングに基づく塩基性薬物の肝・腎排泄機構の解析

1997 - 1998 Individual dosage regimen based on population pharmacokinetics and genotyping of drug metabolizing enzymes

1997 - 1997 薬剤性腎障害発現におけるアポトーシスの役割に関する研究

1996 - 1997 Molucular analysis of tissue distribution and structure-function relationship of transporters responsible for the regulation of drug transport

1995 - 1996 Kietic analysis and evaluation of drug absorption and excretion using cultured cells.

1995 - 1995 小腸,腎尿細管におけるジペプチド輸送担体のCDNAクローニングと機能解析

1992 - 1993 Kinetics of Rena1 Dispositon and Pharmacological Effect of Peptides

薬物体内動態の基礎と臨床

薬剤性腎障害の解析と防御

薬物輸送機構の分子論的解析

Pharmacokintics from bench to bedside

Analysis and Protection of Drug-induced Nephrotoxicity

Molecular Analysis of Drug Transport Mechanism.

Show all

Papers (267)：

Fumihiro Yamane, Kenji Ikemura, Masayoshi Kondo, Manami Ueno, Masahiro Okuda. Identification of dequalinium as a potent inhibitor of human organic cation transporter 2 by machine learning based QSAR model. Scientific reports. 2025. 15. 1. 2581-2581
Kotaro Kawashima, Kenji Ikemura, Miho Takemura, Yuji Toyozumi, Masahiro Okuda. Febuxostat enhances the efficacy of dasatinib by inhibiting ATP-binding cassette subfamily G member 2 (ABCG2) in chronic myeloid leukemia cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024. 181. 117709-117709
Takuya Shintani, Yu-Ting Shun, Yuji Toyozumi, Kenji Ikemura, Takayuki Shiroyama, Izumi Nagatomo, Kentaro Jingushi, Yoshito Takeda, Atsushi Kumanogoh, Masahiro Okuda. MicroRNA-130a-3p regulates osimertinib resistance by targeting runt-related transcription factor 3 in lung adenocarcinoma. Scientific reports. 2024. 14. 1. 24429-24429
Miho Takemura, Kenji Ikemura, Masahiro Okuda. Effect of Hydration with Bicarbonate Ringer's Solution on Cisplatin-Induced Acute Kidney Injury in Patients with Esophageal Cancer: A Retrospective Cohort Study. Oncology. 2024. 1-8
Danni Wang, Kenji Ikemura, Tsubasa Hasegawa, Fumihiro Yamane, Masahiro Okuda. Contribution of human organic anion transporter 3-mediated transport of a major linezolid metabolite, PNU-142586, in linezolid-induced thrombocytopenia. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024. 175. 116801-116801

ｍore...

MISC (286)：

唐寧佳, 池村健治, 池村健治, 池村健治, 山根章寛, 若井恵里, 前田真一郎, 前田真一郎, 前田真一郎, 奥田真弘, et al. 大阪大学医学部附属病院におけるポリファーマシーの実態調査. 医療薬学フォーラム講演要旨集. 2023. 31st
門脇裕子, 木下徳康, 上野耕司, 原伸輔, 西川満則, 阪森亮太郎, 武田理宏, 北村温美, 中島和江, 奥田真弘. 免疫抑制・化学療法により発症するB型肝炎再活性化防止への取り組み. 医療の質・安全学会誌. 2019. 14. Suppl. 409-409
Masahiro OKUDA, Keiko TAKEUCHI. 三重県薬剤師会・三重県病院薬剤師会の取り組み. 週刊薬事新報(Web). 2019. 3102. 625-630 (WEB ONLY)
岡本明大, 安積良紀, 須藤宏文, 中川裕司, 水谷栄梨, 濱口直美, 岩本卓也, 奥田真弘. 手術部門における麻薬管理業務の電子化による業務効率に関する評価-Efficiency of Computerized Narcotic Drug Management in a Surgical Operation Division. 日本病院薬剤師会雑誌 = Journal of Japanese Society of Hospital Pharmacists. 2019. 55. 6. 658-662
榎屋友幸, 奥田真弘, 西川晃平, 杉村芳樹. CYP3A5の遺伝子多型とタクロリムスのTDM. TDM研究. 2019. 36. 2. 61-61

ｍore...

Patents (2)：

Pharmaceutical composition for preventing and/or treating hearing impairment
マイクロRNA145(miR-145)によるMDR1/P-糖タンパク質(P-gp)の転写後発現調節

Books (7)：

抗がん剤のPK-PD. 腫瘍薬学 (川西正祐, 中瀬一則, 大井一弥編)
南山堂 2010
SLCトランスポーター SLC22A2. 薬物トランスポーター活用ライブラリー (乾賢一編)
羊土社, 東京 2009
SLCトランスポーター SLC22A1. 薬物トランスポーター活用ライブラリー (乾賢一編)
羊土社, 東京 2009
有機カチオントランスポーターOCTs. 創薬動態-医薬品創製のための考え方と最新情報- (玉井郁巳, 鈴木洋史, 千葉雅人, 笠井英史編)
日本薬物動態学会, 東京 2006
薬物血中濃度モニタリング(TDM) - 概論, 医療薬学第4版 (乾賢一, 奥村勝彦編)
廣川書店, 東京 2005

ｍore...

Lectures and oral presentations (416)：

妊娠後に子宮頸がんと診断され,妊娠中に化学療法を施行し生児を得た1症例の発育について
(日本臨床腫瘍薬学会学術大会講演要旨集 2019)
三重県内の施設における抗がん薬による曝露対策の変化-2009年調査との比較-
(日本臨床腫瘍薬学会学術大会講演要旨集 2019)
大量メトトレキサート療法時の肝障害発現に及ぼすフェブキソスタット併用の影響
(日本薬学会年会要旨集(CD-ROM) 2019)
メスナの持続投与により大量イホスファミド療法による出血性膀胱炎の発現を軽減できた骨肉腫の症例
(日本小児臨床薬理学会雑誌 2019)
ナルデメジン投与後の下痢発現に対する危険因子探索に関するコホート研究
(日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会講演要旨集 2018)

ｍore...

Education (3)：

1989 - 1993 Kyoto University Graduate School of Pharmaceutical Sciences
1987 - 1989 Kyoto University Graduate School of Pharmaceutical Sciences
1983 - 1987 Kyoto University Faculty of Pharmaceutical Sciences

Professional career (2)：

Master of Pharmaceutical Science
Doctor of Pharmaceutical Science

Work history (13)：

2018/11 - 2019/04 Mie University Hospital
2004/10 - 2019/04 Mie University Hospital Department of Pharmacy Professor and Director
2006/01 - 2018/03 Mie University Hospital Clinical Research Support Center
2002/11 - 2004/09 Kyoto University Hospital Department of Pharmacy Associate Professor and Vice Director
2002/04 - 2002/10 Kyoto University Hospital Department of Pharmacy Lecturer

Show all

Committee career (71)：

2022/09 - 現在 Science Council of Japan member
2022/07 - 現在 Osaka Hospital Phamacist Association Vice President
2022/04 - 現在 Toyono-Mishima District Pharmaceutical Cooperation Council member
2022/04 - 現在 Japan Medical Safety Research Organization Inverstigator
2022/03 - 現在 Japanese Society of Pharmaceutical Health Care and Sciences Auditor

Show all

Awards (4)：

2015/10 - International Association of Therapeutic Drug Monitoring and Clinical Toxicology Best poster in TDM
2010 - 医療薬学フォーラム2010優秀ポスター賞(日本薬学会医療薬科学部会)
2009 - DMPK Award for the Most Frequently Cited Original Article in 2005(日本薬物動態学会)
1996/01 - Kinki Branch, Pharmaceutical Society of Japan Young Investigator's Award, Pharmaceutical Society of Japan, Kinki Branch

Association Membership(s) (17)：

日本癌学会 , 日本臨床薬理学会 , 日本TDM学会 , 日本薬学会医療薬科学部会 , 日本医療薬学会 , 日本薬剤学会 , 日本薬物動態学会 , 日本薬学会 , Japanese Society of Pharmaceutical Health Care and Sciences (1998-) (Japan) , Japan (1997-) , The Academy of Pharmaceutical Science and Technology , Japanese Society of Nephrology (1996-) , Japanese Society of the Study of Xenobiotics (1994-) , Pharmaceutical Society of Japan (1988-) , International Association of Therapeutic Drug Monitoring and Clinical Toxicology , Japanese Society of Drug Informatics , 日本アプライド・セラピューティクス学会

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page


	Free word	※Add the following synonyms, you can increase the number of hits.




		～