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J-GLOBAL ID：200901074270994913 Update date: Apr. 22, 2025

Hatano Etsuro

ハタノエツロウ | Hatano Etsuro

Affiliation and department：
Job title： Professor

Research field (3)： Digestive surgery , General surgery, pediatric surgery , Medical biochemistry

Research keywords (9)： multidisciplinary treatment , navigation for surgery , less invasive surgery , アポトーシス , 胆道癌 , 肝細胞癌 , Apoptosis , Biliary cancer , Hepatocellular carcinoma

Research theme for competitive and other funds (44)：

2024 - 2028 マウス脂肪肝移植を用いた代謝免疫学的アプローチによる肝虚血再灌流障害の機序解明
2023 - 2028 切除不能な肝門部領域胆管癌に対する生体肝移植で治癒に至る分子生物学的特性の解明
2024 - 2027 腹腔内脂肪分解抑制による術後膵液瘻重症化予防法の確立
2024 - 2027 新規治療法を目指した細胆管細胞癌の臨床病理学解析およびゲノム解析による統合解析
2024 - 2027 肝切除後門脈血流刺激に対する内皮細胞応答の解析と肝線維化に伴う内皮機能障害の修復

2023 - 2026 Precise liver gene theraphy based on individual HO-1 morphism with normothermic machine perfusion

2022 - 2025 The establishment of biliary drainage system in bio-engineered liver

2022 - 2025 非感染性炎症における新たな自然免疫細胞制御機構の探求

2022 - 2025 胆道癌の腫瘍内不均一性を基盤とした新規治療標的の開発

2021 - 2024 Analysis of molecular mechanisum of pancreatic cancer cell death and immune responce after carbon ion radiiation and its application to surgery

2021 - 2024 超音波レオロジー理論を用いた脂肪性肝障害の病態解明と非侵襲的組織診断法の確立

2021 - 2024 Development of a Next Generation Surgical Navigation System Using Vascular Visualization Technology

2021 - 2024 Development of digital evaluation system of gastric conduit blood flow using ICG fluorescence imaging projection

2020 - 2023 Role of hepato-splenic interaction in portal hypertension

2019 - 2022 マイクロバブルを用いた血流解析による、転移性肝癌viability評価方法の確立

2019 - 2022 Functional analysis of IL-11 in chalangiocarcinoma and its clinical application

2018 - 2021 Molecular mechanisms of regulation of abdominal adhesion formation by anti-IL-6 antibody.

2016 - 2019 Elucidation of pathophysiology of chemotherapy-induced liver injury by pig proteomics and development of diagnostic biomarkers

2016 - 2019 Imaging Mass Spectrometry of Liver Regeneration

2015 - 2017 Regulation of metabolism and inflammation through hepatic vagus nerve system in steatohepatitis

2012 - 2015 Identification of risk factors of hepatocarcinogenesis in fatty liver disease through the comprehensive analysis of epigenetic alterations

2012 - 2014 Establishment of risk assessment for liver resection by liver stiffness measurement with acoustic radio force impulse (ARFI)

2011 - 2014 Control of liver fibrosis after transplantation by immunomodulation

2010 - 2012 Construction of administration algorithm of novel oral molecular-targeted anti-cancer drugs based on the clarificationof interindividual differences of pharmacokinetics and pharmacodynamics

2008 - 2010 Establishment of a new method of inducing differentiation from human embryonic stem cells to hepatocytes in vitro and investigation of the clinical utility for cell transplantation.

2008 - 2010 Modification of endoplasmic reticulum stress expands surgical indication in hepatocellular carcinom a

2003 - 2010 Clinical randomized study for establishment of standard therapy for hepatocellular carcinoma

2007 - 2007 新規抗癌剤による肝障害予防対策-転移性肝癌に対する安全な拡大肝切除のために-

2006 - 2007 Establishment of hepatocyte differentiation from human embryonic stem cells in the realizaion of cell transplantation therapy for liver disease.

2006 - 2007 腫瘍血管新生と低酸素環境を標的としたテーラーメード癌治療法の創出

2006 - 2007 The role of intermediateted filament proteins in hepatic stellate cells in the development of liver fibrosis and hepatocellular carcinoma

2006 - 2007 Establishment of the maintenance for hepatic stem/progenitor cells with undifferentiated state using mesenchymal cells

2004 - 2006 The development of new radiofrequency device and its clinical application

2005 - 2005 「がん抑抑遺伝子」Sept4遺伝子破壊マウスの解析

2005 - 2005 肝線維化と肝再生におけるアポトーシス関連遺伝子Septin4の機能解析

2004 - 2005 Improvement of perioperative and postoperative management after hepatic resection for HCC by the regulation of hepatic stellate cells.

2003 - 2004 Contribution to the extended hepatectomy by the modulation of endoplasmic reticulum stress-induced cell death

2003 - 2004 ROCK/Rhoシグナル伝達系制御による肝虚血再潅流障害抑制の新しい治療戦略

2000 - 2004 肝臓外科におけるアポトーシスの役割

2000 - 2004 The role of apoptosis in liver surgery

2002 - 2003 Resarch on trial to suppress surgical in cirrhotic liver by modulating activation of hepatic sinusoidal cells.

肝細胞癌標準治療確立のための多施設共同臨床試験

生体内アポトーシスの検出法の開発

Development of in vivo detection of apoptosis

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Papers (917)：

Shuhei Kanda, Hiroto Nishino, Takahiro Nishio, Tariq Awidah, Kentaro Chikamori, Tomoaki Yoh, Shoichi Kageyama, Satoshi Ogiso, Takayuki Anazawa, Takamichi Ishii, et al. ASO Author Reflections: Potential for Fluorescence-Guided Liver Surgery Utilizing Fluorescence Intensity Differences from Multiple Indocyanine Green Doses. Annals of surgical oncology. 2025. 32. 4. 2485-2486
Junichi Shindoh, Masaru Matsumura, Shohei Komatsu, Takumi Fukumoto, Akihiko Ichida, Kiyoshi Hasegawa, Takamichi Ishii, Etsuro Hatano, Masafumi Nakamura, Masayuki Ohtsuka. Prognostic factors and clinical significance of preoperative systemic therapy in patients with borderline resectable hepatocellular carcinoma: A JSHBPS project study 2023, Part 2. Journal of hepato-biliary-pancreatic sciences. 2025
Atsushi Takai, Yoshihide Ueda, Etsuro Hatano, Hiroshi Seno. The Eradication of Hepatitis C Virus after Liver Transplantation Improved Liver Function and Maintained the Health-related Quality of Life. Transplantation proceedings. 2025
Tatsuki Ikejiri, Tomoaki Yoh, Yosuke Kasai, Kazuyuki Nagai, Etsuro Hatano. Hepatic Recurrence of Neuroendocrine Tumor Component in Gallbladder Cancer. Clinical nuclear medicine. 2025. 50. 3. e166-e167
Takashi Ito, Kojiro Taura, Ken Fukumitsu, Shinya Okumura, Satoshi Ogiso, Takayuki Anazawa, Kazuyuki Nagai, Yoichiro Uchida, Takamichi Ishii, Etsuro Hatano. Safety and efficacy of living donor liver transplantation for unresectable perihilar cholangiocarcinoma: A single center prospective study. Journal of hepato-biliary-pancreatic sciences. 2025

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MISC (605)：

小木曾聡, 石井隆道, 波多野悦朗. Liver parenchymal dissection using CUSA/waterjet. 外科. 2024. 86. 12
石井隆道, 石井隆道, 楊知明, 西野裕人, 西尾太宏, 門野賢太郎, 小木曾聡, 穴澤貴行, 長井和之, 内田洋一朗, et al. 手術がきっと上手くなる!こだわりのオペレコ肝細胞癌に対する腹腔鏡下左肝切除の手術記録. 消化器外科. 2024. 47. 11
倉橋光輝, 穴澤貴行, 山根佳, 出羽彩, 長井和之, 笠井洋祐, 小木曾聡, 内田洋一朗, 伊藤孝司, 石井隆道, et al. 膵頭十二指腸切除術の術後栄養状態に及ぼす低侵襲手術の影響. 膵臓(Web). 2024. 39. 3
小木曾聡, 石井隆道, 波多野悦朗. エネルギーデバイスアラカルト知っておきたい使い方の留意点と技術革新各種デバイスの原理・有用性と使用上の注意点水圧式ナイフ. 臨床婦人科産科. 2024. 78. 12
西尾太宏, 楊知明, 西野裕人, 小木曾聡, 穴澤貴行, 長井和之, 内田洋一朗, 伊藤孝司, 石井隆道, 波多野悦朗. 肝細胞癌の再発治療における薬物療法の有用性. 日本肝がん分子標的治療研究会プログラム・抄録集. 2024. 30th

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Works (2)：

肝アポトーシスにおけるSept4の役割
2004 - 2006
The role of Sept4 in liver apoptosis
2004 - 2006

Education (4)：

- 1997 Kyoto University
- 1997 Kyoto University Graduate School of Medicine Gastroenterological Surgery
- 1989 Kyoto University Faculty of Medicine Department of Medical Science
- 1989 Kyoto University Faculty of Medicine

Professional career (1)：

Degree of Medicine (Kyoto University)

Work history (7)：

2021/04 - 現在 Graduate School of Medicine, Kyoto University Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery Professor
2019/12 - 2021/09 Hyogo College of Medicine Professor and Chairman
1998 - 2000 Research Fellow,
1997 - 1998 Research Associate,
the Japan Society for the Promotion of Science

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Association Membership(s) (17)：

日本癌治療学会 , 日本内視鏡外科学会 , 日本臨床外科学会 , 日本肝臓学会 , 日本消化器病学会 , 日本外科学会 , The Japanese Society of Gastroenterological Surgery , Liver Cancer Study Group of Japan , 日本肝移植学会 , 日本超音波学会 , 日本臨床腫瘍学会 , 日本外科感染症学会 , 日本門脈圧亢進症学会 , 日本膵臓学会 , 日本胆道学会 , 日本移植学会 , 日本肝胆膵外科学会

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