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J-GLOBAL ID：200901074371330307 Update date: Mar. 21, 2025

Nakamura Takuro

ナカムラタクロウ | Nakamura Takuro

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Affiliation and department：
Job title： Professor
Homepage URL (1)： https://tokyo-med-exp-pathol.jimdosite.com

Research field (3)： Experimental pathology , Human pathology , Pathobiochemistry

Research keywords (18)：転写因子 , 骨軟部腫瘍 , レトロウィルス , 動物モデル , 染色体転座 , キメラ遺伝子 , ホメオボックス , 血液腫瘍 , 発がん , transcription factor , bone and soft tissue tumor , retrovirus , animal model , chromosomal translocation , chimeric gene , homeobox , Hematopoietic neoplasm , Carcinogenesis

Research theme for competitive and other funds (33)：

2022 - 2028 先端モデル動物支援プラットフォーム
2022 - 2028 生命科学連携推進協議会
2019 - 2023 Molecular mechanisms of leukemic cell engraftment and expansion in vivo
2016 - 2021 Identification of diagnostic biomarker and novel fusion genes of bone and soft tissue sarcoma
2016 - 2021 生命科学連携推進協議会

2016 - 2021 先端モデル動物支援プラットフォーム

2016 - 2017 がん研究分野の特性等を踏まえた支援活動

2014 - 2017 Modeling fusion gene-associated bone and soft tissue sarcoma and its application to therapies

2014 - 2016 Importance of Sytl/Slp family gene in leukemia

2010 - 2016 Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas

2011 - 2014 Molecular basis of myeloid leukemogenesis

2009 - 2011 Transcription factor network involved in maintenance and regeneration of epithelial progenitor cells in the thymus

2004 - 2010 Integrative Research Toward the Conquest of Cancer

2008 - 2009 白血病原因遺伝子としてのmiRNAの同定

2005 - 2009 Research on the molecular mechanism of carcinogenesis using retroviral insertional mutagenesis

2005 - 2009 The core unit supporting research, communication, network and young scientists in the cancer research field

2004 - 2009 Genetic and Epigenetic Dysregulation in Cancer

2007 - 2008 The function of Xbp-1 under the IL-3 signaling in hematopoiesis and leukemogenesis

2005 - 2007 Function of BCL11A in B-cell development

2000 - 2004 Study of hematopoietic tumor disease genes using mouse models

2000 - 2002 Identification of target genes for chimeric transcription factors in malignant mesenchymal tumors

1997 - 1999 Analysis of homeobox gene function in hematopoietic cells and leukemia.

1998 - 1998 マウス骨髄性白血病原因遺伝子Evi-9の同定とその解析

1997 - 1997 マウス骨髄性白血病原因遺伝子Evi-9の同定とその解析

1985 - 1986 本邦における黒色腫の組織発生における真皮内メラノサイトの関与と評価

転写因子の標的遺伝子の同定と解析

BXH2マウスを用いた白血病原因遺伝子の研究

白血病発症におけるホメオボックス遺伝子の役割

Identification and Analysis of Transcription Factor Targets

Study on Leukemia Disease Gene Using BXH2 Mouse

Role of Homeobox genes in Leukemogenesis

Role of transcription factors and transcriptional regulation in carcinogenesis

発がんにおける転写因子と転写調節作用の役割

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Papers (94)：

Yoshitaka Sunami, Seiko Yoshino, Yukari Yamazaki, Takashi Iwamoto, Takuro Nakamura. Rapid increase of C/EBPα p42 induces growth arrest of acute myeloid leukemia (AML) cells by Cop1 deletion in Trib1-expressing AML. Leukemia. 2024
田中美和, 角南義孝, 中村卓郎, 丸山玲緒. 新しいscience & technologyが拓く病理研究の将来展望がん微小環境とエピゲノム異常を制圧する治療法開発(Development of novel therapeutic approaches targeting the tumor microenvironment and deregulated enhancers). 日本病理学会会誌. 2024. 113. 2. 69-69
角南義孝, 芳野聖子, 中村卓郎, 中村卓郎. Cop1欠損によるC/EBPα p42の急速な発現増加はTrib1高発現AML細胞の増殖停止を誘導する(Rapid increase of C/EBPα p42 expression by Cop1 deletion induced growth arrest in Trib1-expressing AML cells). 日本癌学会総会記事. 2024. 83回. E-2063
田中美和, 横川隆司, 中村卓郎, 丸山玲緒. モデル動物が解き明かす肉腫微小環境の形成機構(Sarcoma mouse models clarify development mechanisms of tumor microenvironment). 日本癌学会総会記事. 2024. 83回. J-1019
Takuro Nakamura, Miwa Tanaka. [Alveolar Soft Part Sarcoma-The Angiogenic Mechanism Regulated by a Fusion Gene Product]. Gan to kagaku ryoho. Cancer & chemotherapy. 2024. 51. 6. 585-590

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MISC (61)：

田中美和, 田中美和, 角南義孝, 中村卓郎, 丸山玲緒. Application of epigenome editing technology for targeted cancer therapy. 日本ゲノム編集学会大会要旨集. 2024. 9th
角南義孝, 芳野聖子, 中村卓郎. Rapid increase of C/EBPα p42 expression by Cop1 deletion induced growth arrest in Trib1-expressing AML cells. 日本癌学会学術総会抄録集(Web). 2024. 83rd
山下享子, 馬場郷子, 冨樫由紀, 阿江啓介, 松本誠一, 植野映子, 中村卓郎, 蛭田啓之, 町並陸生, 竹内賢吾. 軟部血管線維腫の臨床病理学的検討. 日本病理学会会誌. 2022. 111. 1. 256-256
角南義孝, 中村卓郎. Bcl11a-コリプレッサー複合体によるエピジェネティック変化を介したAML発症,悪性化機序の解明. 金沢大学がん進展制御研究所がんの転移・薬剤耐性に関わる先導的共同研究拠点. 2022. 2021
角南義孝, 芳野聖子, 中村卓郎. The role of E3 ubiquitin ligase Cop1 in AML development and progression. 日本癌学会学術総会抄録集(Web). 2022. 81st

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Education (4)：

- 1985 Tokyo Medical and Dental University
- 1985 Tokyo Medical and Dental University Graduate School, Division of Medicine
- 1981 Tokyo Medical and Dental University Faculty of Medicine School of Medicine
- 1981 Tokyo Medical and Dental University Faculty of Medicine

Professional career (1)：

(BLANK) (Tokyo Medical and Dental University)

Work history (11)：

2022/04 - 現在 Tokyo Medical University Department of Experimental Pathology, Institute of Medical Science Professor
2012/05 - 2022/03 Japanese Foundation for Cancer Research The Cancer Institute Vice Director
1997 - 1999 科学技術振興事業団さきがけ研究21 研究員
1997 - 1999 Japan Science and Technology Corporation, Researcher
1999 - - (財)癌研究会癌研究所発がん研究部部長

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Committee career (1)：

1992 - 日本病理学会評議員

Awards (1)：

2021/10 - Japanese Cancer Association Tomizo Yoshida Prize Elucidation of carcinogenic mechanisms by disease gene identification and modeling

Association Membership(s) (3)：

日本分子生物学会 , 日本癌学会 , 日本病理学会

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