Rchr
J-GLOBAL ID：200901074371330307
Update date: Jan. 31, 2024
Nakamura Takuro
ナカムラ タクロウ | Nakamura Takuro
Affiliation and department：
Job title：
Professor
Homepage URL (1)：
https://tokyo-med-exp-pathol.jimdosite.com
Research field (3)：
Experimental pathology
, Human pathology
, Pathobiochemistry
Research keywords (18)：
転写因子
, 骨軟部腫瘍
, レトロウィルス
, 動物モデル
, 染色体転座
, キメラ遺伝子
, ホメオボックス
, 血液腫瘍
, 発がん
, transcription factor
, bone and soft tissue tumor
, retrovirus
, animal model
, chromosomal translocation
, chimeric gene
, homeobox
, Hematopoietic neoplasm
, Carcinogenesis
Research theme for competitive and other funds (33)：
- 2022 - 2028 先端モデル動物支援プラットフォーム
- 2022 - 2028 生命科学連携推進協議会
- 2019 - 2023 Molecular mechanisms of leukemic cell engraftment and expansion in vivo
- 2016 - 2021 Identification of diagnostic biomarker and novel fusion genes of bone and soft tissue sarcoma
- 2016 - 2021 生命科学連携推進協議会
- 2016 - 2021 先端モデル動物支援プラットフォーム
- 2016 - 2017 がん研究分野の特性等を踏まえた支援活動
- 2014 - 2017 Modeling fusion gene-associated bone and soft tissue sarcoma and its application to therapies
- 2014 - 2016 Importance of Sytl/Slp family gene in leukemia
- 2010 - 2016 Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas
- 2011 - 2014 Molecular basis of myeloid leukemogenesis
- 2009 - 2011 Transcription factor network involved in maintenance and regeneration of epithelial progenitor cells in the thymus
- 2004 - 2010 Integrative Research Toward the Conquest of Cancer
- 2008 - 2009 白血病原因遺伝子としてのmiRNAの同定
- 2005 - 2009 Research on the molecular mechanism of carcinogenesis using retroviral insertional mutagenesis
- 2005 - 2009 The core unit supporting research, communication, network and young scientists in the cancer research field
- 2004 - 2009 Genetic and Epigenetic Dysregulation in Cancer
- 2007 - 2008 The function of Xbp-1 under the IL-3 signaling in hematopoiesis and leukemogenesis
- 2005 - 2007 Function of BCL11A in B-cell development
- 2000 - 2004 Study of hematopoietic tumor disease genes using mouse models
- 2000 - 2002 Identification of target genes for chimeric transcription factors in malignant mesenchymal tumors
- 1997 - 1999 Analysis of homeobox gene function in hematopoietic cells and leukemia.
- 1998 - 1998 マウス骨髄性白血病原因遺伝子Evi-9の同定とその解析
- 1997 - 1997 マウス骨髄性白血病原因遺伝子Evi-9の同定とその解析
- 1985 - 1986 本邦における黒色腫の組織発生における真皮内メラノサイトの関与と評価
- 転写因子の標的遺伝子の同定と解析
- BXH2マウスを用いた白血病原因遺伝子の研究
- 白血病発症におけるホメオボックス遺伝子の役割
- Identification and Analysis of Transcription Factor Targets
- Study on Leukemia Disease Gene Using BXH2 Mouse
- Role of Homeobox genes in Leukemogenesis
- Role of transcription factors and transcriptional regulation in carcinogenesis
- 発がんにおける転写因子と転写調節作用の役割
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Papers (81)：
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Miwa Tanaka, Mizuki Homme, Yasuyo Teramura, Kohei Kumegawa, Yukari Yamazaki, Kyoko Yamashita, Motomi Osato, Reo Maruyama, Takuro Nakamura. HEY1-NCOA2 expression modulates chondrogenic differentiation and induces mesenchymal chondrosarcoma in mice. JCI insight. 2023. 8. 10
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Miwa Tanaka, Surachada Chuaychob, Mizuki Homme, Yukari Yamazaki, Ruyin Lyu, Kyoko Yamashita, Keisuke Ae, Seiichi Matsumoto, Kohei Kumegawa, Reo Maruyama, et al. ASPSCR1::TFE3 orchestrates the angiogenic program of alveolar soft part sarcoma. Nature communications. 2023. 14. 1. 1957-1957
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Miwa Tanaka, Takuro Nakamura. Targeting epigenetic aberrations of sarcoma in CRISPR era. Genes, chromosomes & cancer. 2023
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Kyoko Yamashita, Satoko Baba, Yuki Togashi, Akito Dobashi, Keisuke Ae, Seiichi Matsumoto, Miwa Tanaka, Takuro Nakamura, Kengo Takeuchi. Clinicopathologic and genetic characterization of angiofibroma of soft tissue: a study of 12 cases including two cases with AHRR::NCOA3 gene fusion. Histopathology. 2023
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Takuo Katsumoto, Yoko Ogawara, Kazutsune Yamagata, Yukiko Aikawa, Ryo Goitsuka, Takuro Nakamura, Issay Kitabayashi. MOZ is critical for the development of MOZ/MLL-fusion-induced leukemia through regulation of Hoxa9/Meis1 expression. Blood Advances. 2022
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MISC (54)：
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角南義孝, 芳野聖子, 中村卓郎. The role of E3 ubiquitin ligase Cop1 in AML development and progression. 日本癌学会学術総会抄録集(Web). 2022. 81st
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田中 美和, 中村 卓郎. 骨軟部肉腫の特性を規定するスーパーエンハンサーの役割. 日本癌学会総会記事. 2021. 80回. [IS4-5]
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中村 卓郎, 芳野 聖子. Trib1によるHoxa9転写制御の修飾とAML発症. 血液内科. 2021. 83. 1. 115-120
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芳野 聖子, 中村 卓郎. Pseudokinase TRIB1による骨髄系腫瘍の発症と進展機構. 血液内科. 2021. 82. 4. 573-579
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Yoshitaka Sunami, Seiko Yoshino, Takashi Yokoyama, Takuro Nakamura. Bcl11a promotes myeloid leukemogenesis by abrogating transcriptional activity of PU.1. CANCER SCIENCE. 2021. 112. 455-455
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Education (4)：
- - 1985 Tokyo Medical and Dental University
- - 1985 Tokyo Medical and Dental University Graduate School, Division of Medicine
- - 1981 Tokyo Medical and Dental University Faculty of Medicine School of Medicine
- - 1981 Tokyo Medical and Dental University Faculty of Medicine
Professional career (1)：
- (BLANK) (Tokyo Medical and Dental University)
Work history (11)：
- 2022/04 - 現在 Tokyo Medical University Department of Experimental Pathology, Institute of Medical Science Professor
- 2012/05 - 2022/03 Japanese Foundation for Cancer Research The Cancer Institute Vice Director
- 1997 - 1999 科学技術振興事業団さきがけ研究21 研究員
- 1997 - 1999 Japan Science and Technology Corporation, Researcher
- 1999 - - (財)癌研究会癌研究所発がん研究部部長
- 1990 - 1997 The University of Tokyo
- 1990 - 1997 The University of Tokyo, Lecturer
- 1987 - 1990 沖中記念成人病研究所 研究員
- 1987 - 1990 Okinaka Memorial Institute for Clinicd Medicior, Researcher
- 1985 - 1987 Tokyo Medical and Dental University
- 1985 - 1987 Tokyo Medical and Dental University, Research Assistant
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Committee career (1)：
Awards (1)：
- 2021/10 - Japanese Cancer Association Tomizo Yoshida Prize Elucidation of carcinogenic mechanisms by disease gene identification and modeling
Association Membership(s) (3)：
日本分子生物学会
, 日本癌学会
, 日本病理学会
