Rchr

J-GLOBAL ID：200901075007121030 Update date: Jan. 31, 2024

Tanaka Shinji

タナカシンジ | Tanaka Shinji

Affiliation and department：
Job title： Assistant Professor
Homepage URL (1)： http://www.tmd.ac.jp/grad/msrg/

Research field (3)： Digestive surgery , General surgery, pediatric surgery , Pathobiochemistry

Research keywords (6)：病態医化学 , 外科腫瘍学 , 消化器外科学 , Pathological Medical Chemistry , Surgical Oncology , Gastroenterological Surgery

Research theme for competitive and other funds (73)：

2022 - 2025 正常免疫マウス腫瘍モデルを応用したヒトスキルス胃がんに対する複合免疫療法の開発
2022 - 2025 神経内分泌腫瘍におけるマルチアナライトバイオマーカーの創設と疾患管理
2022 - 2025 Establishment of detection technique for schirrous stomach cancer and estimation technique for progress degree in early stomach cancer using circulalry polarized light scattering
2021 - 2024 腸内細菌による膵臓癌化学療法抵抗性の機序解明と革新的治療法開発
2021 - 2024 膵臓癌における化合物スクリーニングによる新規抗がん剤併用療法の開発と臨床応用

2021 - 2024 The molecular mechanism of hepatocellular carcinoma associated fibroblast oriented exosome miRNA

2020 - 2023 Envolvement of abnormal of SETDB-related histone modification enzyme and tumor immune environment in gastrointestinal cancer

2020 - 2022 Application of multiplex genome editing technology to the development of CAR-T therapy for refractory cancer subtypes

2019 - 2022 Noninvasive diagnoses for malignant neuroendocrine neoplasms

2019 - 2022 Clarification of diversity mechanisms for innovation of refractory cancer treatment

2018 - 2020 Innovation of genome editing technology as the basis to develop molecular subtype panels of intractable cancer

2017 - 2020 Analysis based on the progression of pancreatic cancer and validation by prospective clinical trial

2016 - 2020 Molecular pathology of SET-related histone methyltransferase in refractory cancer

2016 - 2019 Nuclear factor kappa B and tolerance -Immunosuppression of cancer growth and post-organ transplant-

2016 - 2019 Develoment of advanced therapy targeting tumor heterogeneity in refractory cancers

2015 - 2019 Exploration of novel molecular targets in hapato-bilirary-pancreatic cancers

2016 - 2018 Specific kinase analysis and clinicopathological validation in visualized cancer stem cells

2015 - 2018 Gene analyses to assess malignant potential of Pancreatic neuroendocrine neoplasms

2015 - 2018 Development of new diagnosis shear wave methods for liver fibrosis and steatosis

2015 - 2017 可視化がん幹細胞による細胞競合の解析と根治的癌治療開発

2015 - 2017 Clinicopathological analysis and investigation of molecular mechanism of pancreatic cancer stemness using visualizing system.

2015 - 2017 Analysis of in vivo niches and therapeutic targets for cancer stem cells based on the visualization mechanism

2014 - 2017 Development of multidisciplinary therapy for aged liver insufficiency based on the mechanism of hepatic stellate cell dysfunction.

2013 - 2016 Exploratory analysis for imaging biomarkers of hepatocellular carcinoma

2013 - 2016 Identification and clinical application of pathway-based markers for cancer

2013 - 2016 Innovative treatment of refractory digestive cancers based on the stemness visualization system

2010 - 2016 Development of Novel Treatment Strategies Targeting Cancer Stem Cells

2012 - 2015 Clinical application of inhibition of Nuclear Factor-kappa B: oncogenic proliferation and surgical stress

2012 - 2015 The fragility of macrovesicular fatty liver grafts during ischemia reperfusion injury

2010 - 2015 Elucidation of dormant cancer stem cells and their niche properties in human solid tumors

2011 - 2014 Development of multidisciplinary therapy based on mechanism of liver insufficiency in a use of Aged partial graft after liver transplantation.

2011 - 2012 幹細胞機能を基盤とした膵癌幹細胞の病態解析

2010 - 2012 Development of the prediction system of the early response of theSorafenib for advanced hepatocellular carcinoma using contrast enhanced ultrasonography

2010 - 2012 Innovation of cancer treatment based on the refractory mechanism

2011 - 2011 二つの幹細胞特性に基づく肝癌病態解析

2008 - 2011 Study on the molecular diagnosis of metastasis and recurrence and molecular targeted therapy for intractable hepato-pancreatic cancer

2008 - 2010 脂肪肝グラフト部分肝移植における機能不全の解明と統合的治療法の開発

2007 - 2009 Omics analysis of cancer vessel abnormalities as therapeutic targets

2005 - 2009 Cancer stem cells and genes responsible for their development in hematopoietic system

2006 - 2007 Multidisciplinary research for molecular mechanism of cancer progression and development of diagnostic and therapeutic tool

2005 - 2006 Analysis of novel angiogenesis-related genes and development of tumor dormancy therapy

2004 - 2005 Development of molecular- targeting therapy and prediction of mode of recurrence by analysis of molecular mechanism of invasion and metastasis of hepatocellular carcinoma

2004 - 2004 新たに同定した血管新生関連遺伝子群の解析とその制御による癌冬眼化治療の開発

2002 - 2004 Promotion of liver regeneration and intrahepatic metastasis of hepatocellular carcinoma by Histone acetylation

2003 - 2003 新規Wnt/Fzシグナル誘導分子WISP、制御分子Dkk、Kremenの解析

2002 - 2003 Identification of differentiation regulated gene and application to differentiation inducing gene therapy

2002 - 2003 Analysis of newly identified anglogenic genes and the signal inhibition for tumor dormancy therapy

2002 - 2002 新たにクローニングしたWnt/Fzシグナル誘導癌遺伝子と機能抑制遺伝子の解析

2001 - 2002 Wider application of small-for-size partial liver grafting by gene transfer using teromerase reverse transcriptase (TERT).

2001 - 2002 Development of a super liver graft resistant to various kinds of injuries by a gene-transfer technique

2001 - 2001 癌化シグナル伝達Wnt/Fzに関与する新しいがん関連遺伝子の解析

2000 - 2001 Regulation of multiple angiogenic signaling and development of cancer-specific gene therapy

2000 - 2001 Development of a Hybrid Artificial Liver for Treatment of Acute and Chronic Liver Failure Patients

2000 - 2001 エレクトロポレーション法を用いた新たな肝細胞癌に対する遺伝子治療の開発

2000 - 2000 癌化シグナル伝達Wnt/Fzを制御する新しいがん関連遺伝子の同定とその機能解析

1999 - 1999 新しい癌血管新生因子angiopoietinファミリーのシグナル伝達制御による癌治療の試み

1999 - 1999 新しい癌関連遺伝子FzE3シグナル伝達系におけるターゲット遺伝子の同定とその制御

1998 - 1999 pH regulating therapy for hepatocellular carcinoma

1998 - 1999 Clinical significance of molecular detection of carcinoma cells

1998 - 1998 癌化シグナル伝達抑制分子による新しい癌治療の試み

1998 - 1998 癌抑制遺伝子における遺伝子欠失機構の解明

1997 - 1998 癌転移におけるシグナル伝達解析と転移規定分子の同定による抑制治療の開発

1997 - 1998 The research for the mechanism of resistance to catalytic topoisomerase II inhibitors

1997 - 1998 BASIC RESEARCH FOR TUMOR SPECIFIC IMMUNOTHERAPY USING TUMOR REJECTED ANTIGEN GENES

血管新生の解析と分子標的治療の開発

癌幹細胞の解析と分子標的治療の開発

消化器癌の分子解析と標的治療の開発

癌遺伝子治療の研究

癌転移の分子生物学的解析

癌化シグナル伝達の分子生物学的解析

Study of Gene Therapy for Cancer

Molecular Analysis of tumor metastasis

Molecular Analysis of Oncogenic Signal Tnansduction

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Papers (209)：

Shu Shimada, Shinji Tanaka. The chronicles of hepatocellular carcinoma classification: Subtyping, modeling, and treatment. Hepatology (Baltimore, Md.). 2024. 79. 2. 261-263
Megumi Hatano, Yoshimitsu Akiyama, Shu Shimada, Kohei Yagi, Keiichi Akahoshi, Michiko Itoh, Minoru Tanabe, Yoshihiro Ogawa, Shinji Tanaka. Loss of KDM6B epigenetically confers resistance to lipotoxicity in nonalcoholic fatty liver disease-related HCC. Hepatology communications. 2023. 7. 10
Momoko Ichihara, Hidekazu Takahashi, Naohiro Nishida, Cristina Ivan, Daisuke Okuzaki, Yuhki Yokoyama, Masahisa Ohtsuka, Norikatsu Miyoshi, Mamoru Uemura, Shinji Tanaka, et al. Long noncoding RNA 01534 maintains cancer stemness by downregulating endoplasmic reticulum stress response in colorectal cancer. Annals of Gastroenterological Surgery. 2022. 7. 3. 458-470
Shu Shimada, Shinji Tanaka. Molecular targeted drugs, comprehensive classification and preclinical models for the implementation of precision immune oncology in hepatocellular carcinoma. International journal of clinical oncology. 2022. 27. 7. 1101-1109
Ayano Kabashima, Yuki Matsuo, Saki Ito, Yoshimitsu Akiyama, Takeshi Ishii, Shu Shimada, Atsushi Masamune, Minoru Tanabe, Shinji Tanaka. cGAS-STING signaling encourages immune cell overcoming of fibroblast barricades in pancreatic cancer. Scientific reports. 2022. 12. 1. 10466-10466

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MISC (334)：

安川紘矢, 秋山好光, 島田周, 田中真二. 胆道癌の分子生物学的サブタイプと治療戦略-Molecular subtypes and molecular targeted therapy in cholangiocarcinoma-特集胆道疾患研究最前線. 消化器・肝臓内科 = Gastroenterology & hepatology / 消化器・肝臓内科編集委員会編. 2022. 11. 1. 33-42
田中真二, 島田周, 秋山好光, 大庭篤志, 渡辺秀一, 奥野圭祐, 水野裕貴, 上田浩樹, 吉野潤, 菅原了子, et al. ゲノム医療・ゲノム編集時代におけるプレシジョン免疫複合療法. 日本外科学会定期学術集会(Web). 2019. 119th
Shu Shimada, Yoshimitsu Akiyama, Hiroshi Fukamachi, Yasuhito Yuasa, Shinji Tanaka. Identification of selective inhibitors of diffuse-type gastric cancer cells by screening of annotated compounds. CANCER RESEARCH. 2016. 76
Treatment strategy for liver metastasis of pancreatic neuroendocrine neoplasms. 2016. 33. 2. 105-109
Hiroki Ueda, Daisuke Ban, Atsushi Kudo, Hiromitsu Ito, Yusuke Mitsunori, Satoshi Matsumura, Arihiro Aihara, Takanori Ochiai, Shinji Tanaka, Minoru Tanabe. Postoperative Cholangitis After Pancreatoduodenectomy: A Retrospective Study. GASTROENTEROLOGY. 2016. 150. 4. S1254-S1254

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Patents (2)：

Inhibition of oncogenic signals
Inhibition of oncogenic signals

Professional career (1)：

M.D., Ph.D.

Committee career (1)：

2019/04 - 現在 JSPS RCSS Senior Program Officer

Awards (11)：

2013 - 日本消化器外科学会賞(第一回学術部門) JSGS Science of the Year 2013
2012 - 日本癌学会学術賞JCA-Mauvernay Award
2007 - IRPC “Gold Medal”, Eminent Scientist of the Year
2006 - 日本学術振興会賞
2006 - JSPS Prize

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Association Membership(s) (4)：

米国癌学会 , 日本消化器外科学会 , 日本癌学会 , 日本外科学会

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