Rchr

J-GLOBAL ID：200901075183004040 Update date: Oct. 31, 2024

Sasaki Shigeki

ササキシゲキ | Sasaki Shigeki

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://210.233.60.66/~bioorg/

Research field (2)： Biochemistry , Pharmaceuticals - chemistry and drug development

Research keywords (6)： nucleic acid chemistry , 生物有機化学 , 医薬分子機能学 , 化学系薬学 , Biological Organic Chemistry , Pharmaceutical Organic Chemistry

Research theme for competitive and other funds (44)：

2024 - 2027 Basic research into nucleic acid drugs that induce readthrough by chemically modifying the adenosine at the premature termination codon
2021 - 2025 Development of small molecule drugs for fragile X syndrome based on ligands that cooperatively accumulate on the CGG repeats.
2021 - 2025 Drug discovery for fragile X syndrome based on the small molecular ligands that form self-assembles on the CGG repeats
2019 - 2024 Molecular design of innovative drugs based on molecular assembly
2018 - 2021 Development of the artificial oligonucleotides for the RNA pinpoint modification and the application to RNA editing

2016 - 2018 Development of small molecular ligands for simultaneous binding to the multiple sites of DNA

2015 - 2018 Chemically reactive oligonucleotides for site-specific modification of RNA and artificial RNA editing

2015 - 2017 Development of capture probes for the signaling nucleotide molecules in cells

2014 - 2016 Development of recognition molecules for 8-oxidized guanosine derivatives

2012 - 2015 官能基転移反応によるRNAの化学修飾法の開発

2012 - 2014 Development of the selective capture molecule for 8-nitroguanosine

2009 - 2014 Study on the innovative molecular-targeting medicine based on the nano-DDS encapsulating intelligent artificial oligonucleotides

2009 - 2013 インテリジェント人工核酸を搭載したナノDDSによる革新的分子標的治療薬の研究

2010 - 2011 Photochromic DNA Binding Ligands for B and Z-DNA Interconversion

2007 - 2011 インテリジェント機能性核酸の開発とナノ医療デバイスへの展開

2008 - 2009 異常に長い繰り返し配列のDNA上に金属イオンを解して自己集積する分子の開発

2008 - 2009 異常に長い繰り返し配列のDNA上に金属イオンを介して自己集積する分子の開発

2005 - 2008 Development of Genome-Targeting Molecules with Ability of Chemical Reactivity and Application to Intelligent Nano-Medicine

2006 - 2007 動的コンビナトリアル化学によるDNA高次構造認識分子の検索

2003 - 2004 ゲノムのピンポイント修飾を目指したDNA配列特異的な官能基転移反応の検討

2003 - 2004 Design of functional molecules for selective recognition and reaction to the duplex DNA

2002 - 2003 次世代遺伝子治療の開発研究

2001 - 2003 Development of gene-mediated radiotherapy for tumors

2001 - 2002 機能性核酸DNA複合体形成によるシンクロナイゼーション活性化

2001 - 2002 Design of the new recognition molecules for the formation of triplex helix DNA at any predetermined sites.

2001 - 2001 DNA結合ペプチドのランダム検索とDNAのペプチド合成触媒としての評価

1999 - 2000 GCおよびAT選択的な新規リガンドを基本とするDNA配列認識分子の創製

1999 - 2000 Development of the New Recognition Molecules of DNA Sequences Based on the GC- and AT-Selective Ligands

1997 - 1998 Molecular design of inhibitors for DNA replication in Escherichia coli

1997 - 1998 Random Search of DNA Recognition Molecules by the Use of the New Combinatorial Technology

1997 - 1997 テロメラーゼを標的とする新しい制癌手法の研究

1997 - 1997 新しいGC配列特異的DNA結合分子の開発と金属イオンによる結合の制御

1996 - 1996 テロメラーゼを標的とする新しい制癌手法の研究

1996 - 1996 酸化およびアルキル化DNA損傷を防ぐヒト酵素の精製と解析

1995 - 1996 Design and Synthesis of New Recognition Molecules for the Sequence-Selective Triple Helical DNA Formation

1994 - 1996 Screening of inhibitors of DNA replication by using the oriC plasmid replication system of Escherichia coli

1993 - 1994 MULTI-SUBSTRATE TYPE INHIBITORS FOR CDC2 KINASE AND THEIR EVALUATION AS SELECTIVE CELL-CYCLE INHIBITORS

1991 - 1992 新規な構造を持つアセトゲニン類をリード化合物とする新しいがん細胞認識分子の探索

1988 - 1989 DESIGN, SYNTHESIS, AND PROPERTIES OF CYCLOPHANES AS HOSTS HAVING ABILITY OF FORMING INCLUSION COMPLEXES

1987 - 1987 クラウンエーテルを用いたペプチド合成機能を有する人工酵素の構築

1985 - 1986 Development of Novel Asymmetric Synthetic Reactions

Study on Novel Bases to Form Non-Native Triple DNA

Study on anti tumor active compounds

Study on chemical methods for site-specific mutagenesis

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Papers (147)：

Hirotaka Murase, Jeongsu Lee, Norihiro Togo, Yosuke Taniguchi, Shigeki Sasaki. The selective chemical modification of the 6-amino group of adenosine of the premature termination codon induces readthrough to produce full-length peptide in the reconstituted E. Coli translation system. Bioorganic & Medicinal Chemistry. 2024. 111. 117868-117868
Shigeki Sasaki, Hirotaka Murase. Manipulating nucleic acids - regulation of gene expression through higher order structure and chemical modification. Drug Delivery System. 2024. 39. 1. 53-62
Akihiro Ito, Lei Wang, Ryotaro Notomi, Shigeki Sasaki, Yosuke Taniguchi. Development of an Artificial Nucleic Acid Skeleton Allowing for Unnatural-Type Triplex DNA Formation with Duplex DNA Having a TA Inversion Site. CHEMICAL & PHARMACEUTICAL BULLETIN. 2024. 72. 1. 16-20
Ryotaro Notomi, Shigeki Sasaki, Yosuke Taniguchi. Post-Synthetic Modification of Triplex-Forming Oligonucleotides Containing 2-Aminoethyl-2′-Deoxynebularine Derivatives. CURRENT PROTOCOLS. 2023. 3. 10
Hirotaka Murase, Jeongsu Lee, Yosuke Taniguchi, Shigeki Sasaki. Site-Specific Tritium Labeling at the Predefined Internal Position of the Chemically-Modified RNA. Chemical and Pharmaceutical Bulletin. 2023. 71. 1. 64-69

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MISC (99)：

Lei Wang, Yong Ling, Yan Tian, Xiao Wang, Shigeki Sasaki, Yosuke Taniguchi. The Development of Non-natural Type Nucleoside to Stabilize Triplex DNA Formation against CG and TA Inversion Site. CURRENT MEDICINAL CHEMISTRY. 2024. 31. 19. 2663-2686
Yosuke Taniguchi, Ryota Kawaguchi, Shigeki Sasaki. Adenosine-1,3-diazaphenoxazine Derivative for Selective Base Pair Formation with 8-Oxo-2 '-deoxyguanosine in DNA (vol 133, pg 7272, 2011). JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2011. 133. 26. 10322-10322
Nagatsugi, F, Sasaki, S. Synthesis of Reactive Oligonucleotides for Gene Targeting and Their Application to Gene Expression Regulation. Bulletin of the Chemical Society of Japan. 2010. 83. 744-755
Kazumitsu Onizuka, Yosuke Taniguchi, Shigeki Sasaki. A new usage of functionalized oligodeoxynucleotide probe for site-specific modification of a guanine base within RNA. NUCLEIC ACIDS RESEARCH. 2010. 38. 5. 1760-1766
Yosuke Taniguchi, Yuko Uchida, Tomoko Takaki, Eriko Aoki, Shigeki Sasaki. Recognition of CG interrupting site by W-shaped nucleoside analogs (WNA) having the pyrazole ring in an anti-parallel triplex DNA. BIOORGANIC & MEDICINAL CHEMISTRY. 2009. 17. 19. 6803-6810

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Patents (1)：

「核酸結合性ビシクロオクタン誘導体」【発明者】佐々木茂貴【特許出願人】株式会社産学連携機構九州「インドール誘導体」、【出願人】三菱化学株式会社、【発明者】前田稔、佐々木茂貴、原田直純、木村淳子「ビニル化デオキシグアノシン誘導体」【発明者】永次史、前田稔、佐々木茂貴、【特許出願人】三菱化学株式会社(平成13年9月、株式会社産学連携機構九州に権利譲渡) 「ビニル化デオキシグアノシン誘導体」発明者】永次史、前田稔、佐々木茂貴、【特許出願人】三菱化学株式会社(平成13年9月、株式会社産学連携機・・・

Books (3)：

化学構造と薬理作用 : 医薬品を化学的に読む
広川書店 2010 ISBN:9784567462402
W-字型核酸塩基アナログによる非天然型3本鎖DNA形成
Tetrahedron Letters 2001
Enzyme Modelling with Crown Ethers
Elsevier 1992

Lectures and oral presentations (64)：

金属を介してDNA上に自己集積する低分子リガンドの効率的合成研究
(日本薬学会第130年会 2009)
DNA高次構造認識分子の開発を目指したポリフィリン誘導体の合成
(日本薬学会第130年会 2009)
3本鎖DNA形成を志向した新規二置換ヌクレオシドアナログの開発
(日本薬学会第130年会 2009)
エチルリンカーを導入したチオグアノシン誘導体の合成と機能性核酸への展開
(第35回反応と合成の進歩シンポジウム 2009)
非天然型3 本鎖DNA 形成を可能にするW字型ビシクロ核酸誘導体の合成と機能評価
(第35回反応と合成の進歩シンポジウム 2009)

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Works (1)：

遺伝子ベクターとして機能するナノ構造デバイスの創製、代表者東京大学大学院工学研究科片岡一則(分担課題:機能性人工核酸の分子設計)
2001 - 2006

Education (4)：

- 1982 The University of Tokyo
- 1982 The University of Tokyo Graduate School, Division of Pharmaceutical Sciences
- 1977 The University of Tokyo Faculty of Pharmaceutical Sciences
- 1977 The University of Tokyo Faculty of Pharmaceutical Science

Professional career (1)：

(BLANK)

Work history (6)：

2020/04 - 現在 Nagasaki International University School of Pharmacy Professor
2002/10 - 2020/03 Kyushu University Graduate School of Pharmaceutical Sciences Professor
1990 - 2002 Kyushu University School of Pharmaceutical Sciences
2002 - - 九州大学大学院薬学研究院教授
1984 - 1990 The University of Tokyo Faculty of Pharmaceutical Sciences

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Committee career (15)：

2023/03 - 現在日本薬学会顧問
2010/01 - 現在日仏医薬精密化学会議組織委員
2021/03 - 2022/03 Pharmaceutical Society of Japan President
2017/04 - 2020/03 日本薬学会副会頭
2015/04 - 2018/07 日本核酸医薬学会会長

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Awards (3)：

2020/10 - The Japan Society of Nucleic Acid Chemistry Ikehara Award
2017/03 - Pharmaceutical Society of Japan The Pharmaceutical Society of Japan Award Development of the novel functional molecules targeting DNA and RNA
2002/03 - The Pharmaceutical Society of Japan Award for Divisional Scientific Contribution Creation of Functional Recognition Molecules for Chemical Modification of Gene Expression

Association Membership(s) (5)：

The Japan Society of Nucleic Acids Chemistry , Nucleic Acids Therapeutic Society of Japan , 日本薬学会 , 有機合成化学協会 , 日本化学会

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