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J-GLOBAL ID：200901075442584603 Update date: Apr. 13, 2025

Takahashi Hideo

タカハシヒデオ | Takahashi Hideo

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Affiliation and department：
Job title： Professor

Research field (5)： General surgery, pediatric surgery , Immunology , Pharmaceuticals - chemistry and drug development , Pharmacology , Pharmaceuticals - health and biochemistry

Research keywords (6)：ターゲットバリデーション , 病態メカニズム , 創薬 , ターゲットバリデーション , 病態メカニズム解析 , 創薬

Research theme for competitive and other funds (43)：

2024 - 2027 Development of control method for inflammaging by targeting advanced glycation end products
2024 - 2027 Role of TNF-alpha in knee osteoarthritis pain and analgesic effect of plasma protein HRG
2023 - 2026 運動介入による再生、修復促進効果の新しい機序の解析研究
2021 - 2024 Homeostatic effect of improvement candidate drug targeting IL-33
2018 - 2021 Basic study of the niche function improvement medicine development that targeted a homeodynamics-related mediator

2017 - 2020 Exsercise intervation improves bone marrow niche and endothelial progenitor cell defects in stroke

2016 - 2019 Functional characterization of histidine-rich glycoprotein (HRG) under the inflammatory conditions.

2016 - 2019 Function and regulation of Nrf2 in mesenchymal stem cells

2015 - 2018 Research for homeodynamics regeneration-promoting drug discovery

2015 - 2018 Mechanism for microthrombus formation on NETosis and development of therapy for ARDS.

2014 - 2017 Exercise promotes homeostatic control and post-injury regeneration by altering stem cell niche

2013 - 2016 New regulation system for liver injury after surgery via immunological reaction against DAMPs

2012 - 2015 Basic scientific research for formulating drugs for treatment of hypertension

2012 - 2015 Drug development for brain and spinal cord trauma targeting HMGB1

2011 - 2013 The development of broad-spectrum antitumor agents with anti-HMGB1 antibody and clarification of its action mechanism

2011 - 2013 The antibody therapy for RAGE ligand in organ transplantation

2011 - 2013 Induction of neurogenesis from endogenous neural precursors in the adult brain after stroke by long-term voluntary execise

2009 - 2011 Development of monoclonal antibodies therapy for cerebral infarction and cerebral edema

2009 - 2011 Mechanism for HMGB-or HMGB1-derived peptide-induced increase in BBB permeability

2009 - 2010 脳浮腫の発生機序解明と創薬標的の同定

2008 - 2010 A novel anti-HMGB1 Ab therapy for treatment of B-cell lymphoma

2009 - 自然炎症のメカニズムの解析

2007 - 2008 虚血性脳障害と学習・記憶過程に共通する原理の探索研究

2006 - 2007 The Effects of HMGB1 on Ischemia-Reperfusion Injury in the Rat Heart.

2005 - 2006 サイトカイン活性を有する核転写因子、ヌクレオサイトカインの情報伝達と敗血症病態

2004 - 2005 Study on regulation of tissue remodeling by histidine rich plasma factors

2003 - 2004 Inducible histamine protects mice from P.acnes-primed and LPS-induced hepatitis through H2-receptor stimulation

2003 - 2004 Proteomics analysis of plasma protein complex regulating leukocyte interaction.

2001 - 免疫応答の対するHMGB1をはじめとしたRAGE ligandsの効果の検討と治療薬開発

インターロイキン18の臨床応用の基礎的検計

プロスタグランディンE2の臨床効果の新しい応用

ヒスタミンの臨床応用

免疫反応に対するプロスタグランディンE2の効果

免疫反応に対するヒスタミンの効果

免疫反応に対するインターロイキン18の効果

Homeostatic Inflammation

Effect of HMGB1 on immune responce and drug discovery

Basic research for Clinical use of IL-18

New Clinical finding of Prostaglandin E2

Clinical use of Histamine

The effect of prostagrandine E2 on immune response

The effect of histamin on immune-response

The effects of interleukin-18 on immune-response

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Papers (125)：

Masahiro Watanabe, Takao Toyomura, Hidenori Wake, Takashi Nishinaka, Omer Faruk Hatipoglu, Hideo Takahashi, Masahiro Nishibori, Shuji Mori. Metolazone and Azosemide, Clinically Utilized Diuretics, Exhibit Inhibitory Activity for Glyoxalase I. Biotechnology and applied biochemistry. 2025. e2760
Omer Faruk Hatipoglu, Takashi Nishinaka, Kursat Oguz Yaykasli, Shuji Mori, Masahiro Watanabe, Takao Toyomura, Masahiro Nishibori, Satoshi Hirohata, Hidenori Wake, Hideo Takahashi. Histidine-rich glycoprotein inhibits TNF-α-induced tube formation in human vascular endothelial cells. Frontiers in pharmacology. 2025. 16. 1561628-1561628
Masahiro Watanabe, Takao Toyomura, Hidenori Wake, Takashi Nishinaka, Omer Faruk Hatipoglu, Hideo Takahashi, Masahiro Nishibori, Shuji Mori. Cationic ribosomal proteins can inhibit pro-inflammatory action stimulated by LPS+HMGB1 and are hindered by advanced glycation end products. Biotechnology and applied biochemistry. 2023. 71. 2. 264-271
Takashi Nishinaka, Omer Faruk Hatipoglu, Hidenori Wake, Masahiro Watanabe, Takao Toyomura, Shuji Mori, Masahiro Nishibori, Hideo Takahashi. Different modulation of STING/TBK1/IRF3 signaling by advanced glycation end products. Archives of biochemistry and biophysics. 2023. 750. 109808-109808
Takao Toyomura, Masahiro Watanabe, Hidenori Wake, Takashi Nishinaka, Omer Faruk Hatipoglu, Hideo Takahashi, Masahiro Nishibori, Shuji Mori. Glycolaldehyde-derived advanced glycation end products promote macrophage proliferation via the JAK-STAT signaling pathway. Molecular Biology Reports. 2023. 50. 7. 5849-5858

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MISC (155)：

渡邊政博, 豊村隆男, 和氣秀徳, 西中崇, 逢坂大樹, 王登莉, 高橋英夫, 西堀正洋, 森秀治. 新規AGEs結合分子AGE-BP2がDAMPsの作用に与える影響の解析. 日本薬理学雑誌. 2021. 156. Supplement
豊村隆男, 渡邊政博, 和氣秀徳, 逢坂大樹, 王登莉, 高橋英夫, 西堀正洋, 森秀治. 終末糖化産物AGE2による細胞増殖効果とTLR2による制御. 日本生化学会大会(Web). 2020. 93rd
豊村隆男, 渡邊政博, 和氣秀徳, 逢坂大樹, 王登莉, 高橋英夫, 西堀正洋, 森秀治. TLR2によるAGE2依存的な細胞増殖制御. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
Takuro Kobori, Shinichi Hamasaki, Atsuhiro Kitaura, Takashi Nishinaka, Atsuko Niwa, Shuji Mori, Masahiro Nishibori, Hideo Takahashi. IL-18 amplifies macrophage M2 polarization and angiogenic capacity through osteopontin. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2017. 133. 3. S252-S252
Takashi Nishinaka, Atsuko Niwa, Takuro Kobori, Hideo Takahashi. Stroke-prone spontaneously hypertensive rat shows the enhanced erythropoiesis. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2017. 133. 3. S258-S258

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Patents (7)：

好中球活性化に起因する疾患の治療薬及び検査方法
外傷性神経障害治療剤
RAGEとAGEの結合抑制剤のスクリーニング方法
好中球活性化に起因する疾患の治療薬及び検査方法
アテローム動脈硬化抑制剤

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Lectures and oral presentations (4)：

ホメオスタシス機構と創薬
(第34回癌免疫外科研究会特別招聘講演 2013)
アレルギー疾患におけるステロイド療法の理論と実際-ステロイド療法と作用機序-
(第62回日本アレルギー学会シンポジウム 2012)
AGE2 and AGE3 induced monocyte activation.
(2011)
ホメオダイナミクス創薬 ~生体内恒常性維持機構の活性化を目指して~
(国立病院機構福山医療センターオープンカンファレンス)

Works (5)：

プロスタグランディン E<sub>2</sub> の臨床効果に関する共同研究
2002 - 2003
ヒスタミンのIL-18産生誘導効果に関する共同研究
1999 -
Joint Research of Effect of Histamine on IL-18 Production
1999 -
IL-18のICAM-1発現効果に関する共同研究
1996 -
Joint Research of Effect of IL-18 on ICAM-1 Expression
1996 -

Education (1)：

Okayama University Medical School Faculty of Medicine

Professional career (1)：

(BLANK) (Okayama University)

Awards (2)：

2002 - 岡山医学会賞
2002 - Okayama Medical Association

Association Membership(s) (3)：

日本免疫学会 , 日本薬理学会 , 日本外科学会

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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