Rchr
J-GLOBAL ID：200901075842211539   Update date: Jun. 23, 2024

Kita Akiko

キタ アキコ | Kita Akiko
Affiliation and department：
Kyoto University Research Reactor Institute, Division of Radiation Life Science

About Kyoto University Research Reactor Institute, Division of Radiation Life Science


Job title： Assistant Professor
Research field  (1)： Structural biochemistry
Research keywords  (2)： 構造生物化学 ,  Structural Biology
Research theme for competitive and other funds  (22)：
  • 2023 - 2026 Development to ultra-early diagnosis and prevention of AD by using a specific antibody against the toxic conformation of amyloid beta
  • 2019 - 2023 Very early diagnosis of Alzheimer's disease by the toxic oligomer specific antibody of amyloid beta
  • 2014 - 2019 Novel Preventive Strategy for Alzheimer's Disease Based on the Toxic Conformation Theory of Amyloid beta
  • 2007 - 2008 The relationship between photoreception and structure change of the short BLUF (the sensor of Blue Light Using FAD) protein
  • 2005 - 2006 短鎖青色光受容体タンパク質のX線結晶構造解析
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Papers (68)：
  • Akiko Kita, Yuna Ishida, Takahiro Shimosaka, Yuta Michimori, Kira Makarova, Eugene Koonin, Haruyuki Atomi, Kunio Miki. Crystal structure of GTP-dependent dephospho-coenzyme A kinase from the hyperthermophilic archaeon, Thermococcus kodakarensis. Proteins: Structure, Function, and Bioinformatics. 2024. 92. 6. 768-775
  • Yumi Irie, Yuka Matsushima, Akiko Kita, Kunio Miki, Tatsuya Segawa, Masahiro Maeda, Ryo C. Yanagita, Kazuhiro Irie. Structural basis of the 24B3 antibody against the toxic conformer of amyloid β with a turn at positions 22 and 23. Biochemical and Biophysical Research Communications. 2022. 621. 162-167
  • Akiko Kita, Yukio Morimoto. Hydrogen/Deuterium Exchange Behavior During Denaturing/Refolding Processes Determined in Tetragonal Hen Egg-White Lysozyme Crystals. Molecular Biotechnology. 2022. 64. 5. 590-597
  • Yusuke Kageyama, Yumi Irie, Yuka Matsushima, Tatsuya Segawa, Jean-Pierre Bellier, Kumi Hidaka, Hiroshi Sugiyama, Daita Kaneda, Yoshio Hashizume, Hiroyasu Akatsu, et al. Characterization of a Conformation-Restricted Amyloid β Peptide and Immunoreactivity of Its Antibody in Human AD brain. ACS Chemical Neuroscience. 2021. 12. 18. 3418-3432
  • Atsushi Saito, Yusuke Kageyama, Olga Pletnikova, Gay L. Rudow, Yang An, Yumi Irie, Akiko Kita, Kunio Miki, Ling Li, Pamela Southall, et al. APOE ε4 allele advances the age-dependent decline of amyloid β clearance in the human cortex. bioRxiv. 2021
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MISC (70)：
  • Akiko Kita, Yuna Ishida, Takahiro Shimosaka, Yuta Michimori, Kira Makarova, Eugene Koonin, Haruyuki Atomi, and Kunio Miki. Crystal structure of dephospho-coenzyme A kinase from archaea. Proceedings of the 58th KURNS Scientific Meeting. 2024. 58. 39-39
  • Akiko Kita, Yukio Morimoto. Deuterated/undeuterated positions in denatured/refolded hen egg lysozyme. Proceedings of the 56th KURNS Scientific Meeting. 2022. 31-31
  • Kazuhiro Irie, Yumi Irie, Yuka Matsushima, Akiko Kita, Yusuke Kageyama, Ikuo Tooyama. Structure analysis of TxCo-1 antibody effective against the toxic conformer of amyloid β. Photon Factory Highlights;PF Highlights2021 ;3. Life Science 3-1. 2022. 30-31
  • Akiko Kita, Yukio Morimoto. Neutron structure analysis of the deuterated denatured/refolded protein crystals. Proceedings of the 55th KURNS Scientific Meeting. 2021. 24-24
  • Akiko Kita, Yukio Morimoto. Neutron crystallographic studies for deuterated protein that reflects the solvent state. Proceedings of the 54th KURNS Scientific Meeting. 2020. 41-41
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Books (3)：
  • 日本の結晶学II
    日本結晶学会 2014
  • 実験化学講座11 物質の構造III 回折 5生体高分子の結晶構造ー5.2結晶化とX線回折実験ー5.2.1結晶化法
    日本化学会編 2006
  • ゲノミクス・プロテオミクスの新展開〜生物情報の解析と応用 第2章第2節・X線結晶構造解析「タンパク質の結晶化」,今中忠行監修,pp. 596-600
    エヌ・ティー・エス 2004
Lectures and oral presentations  (246)：
  • アーキア由来デホスホコエンザイムAキナーゼの結晶構造
    (第24回日本蛋白質科学会年会 2024)
  • アーキア由来デホスホ CoA キナーゼの結晶構造
    (京都大学複合原子力科学研究所第58回学術講演会 2024)
  • アーキア由来補酵素 A 合成経路のデホスホ CoA キナーゼの結晶構造と基質結合様式
    (令和5年(2023年)度日本結晶学会年会 2023)
  • 毒性アミロイドβの立体構造に立脚した抗体開発
    (第12回日本認知症予防学会 2023)
  • 抗Aβオリゴマー抗体・24B3の毒性配座認識機構の解析
    (第41回日本認知症学会学術集会第37回日本老年精神医学界合同年会 2022)
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Education (3)：
  • 1992 - 1995 Tokyo Institute of Technology Graduate School of Integrated Science and Engineering Dept. of Electronic Chemistry
  • 1990 - 1992 Osaka University Graduate School of Engineering Dept. of Applied Precision Chemistry
  • 1986 - 1990 Osaka University Faculty of Engineering Dept. of Applied Precision Chemistry
Professional career (1)：
  • Doctor of Science (Tokyo Institute of Technology)
Work history (9)：
  • 2018/04 - 現在 Kyoto Univ. Institute for Integrated Radiation and Nuclear Science Assistant professor
  • 2007/04 - 2018/03 Kyoto Univ. Research Reactor Inst. Assistant professor
  • 2006/04 - 2011/03 RIKEN HARIMA Institute, Visiting Researcher
  • 2004/04 - 2007/03 Kyoto Univ. Research Reactor Inst. Assistant Professor (Research Reactor Institute, Kyoto Univ., present post)
  • 1999/10 - 2006/03 RIKEN HARIMA Institute, Co-Researcher
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Committee career (6)：
  • 2024/03 - 現在 日本化学会 近畿支部幹事
  • 2023/09 - 現在 令和6年(2024年)度日本結晶学会年会 プログラム委員
  • 2021/04 - 2021/11 日本結晶学会 日本結晶学会令和3年(2021年)度年会プログラム委員
  • 2019/07 - 2019/10 ISDSB2019 executive committee
  • 2005/06 - 2006/05 第6回蛋白質科学会 年会実行委員
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Awards (3)：
  • 2024/03 - 京都大学複合原子力科学研究所 令和5年度複合原子力科学研究所所長賞
  • 2006/05 - Japanese Association of University Women Morita Science Research Award
  • 2002/12 - The Crystallographic Society of Japan Young Researcher Award
Association Membership(s) (5)：
The Biophysical Society of Japan ,  Protein Science Society of Japan ,  The Crystallographic Society of Japan ,  The Chemical Society of Japan ,  The Japanese Biochemical Society
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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