Naoki Sakai

サカイナオキ | Naoki Sakai

Affiliation and department：
Job title： Senior scientist

Research field (1)： Structural biochemistry

Research keywords (4)： X線結晶学 , 構造生物学 , Macromolecule crystallography , Structural biology

Research theme for competitive and other funds (5)：

2022 - 2024 コムギ無細胞系とAirIDを基盤とした複合体生産・探索・解析技術の支援と高度化
2010 - 2012 幅広いインフルエンザHA亜型を認識する抗体とHA複合体の構造生物学的研究
2008 - 2009 The structural biological study of the macromolecular complex involved with formation of SARS-CoV virions
2007 - 2008 腸内細菌の病原性・非病原性と抗菌ペプチドの作用機構の解明
2006 - 2007 SARSコロナウイルスのヌクレオキャプシド蛋白質の構造生物学的研究

Papers (49)：

Seiji Takahashi, Miki Suenaga-Hiromori, Tomoki Ishii, Nadia Nur Shazana Binti Abu Talib Khan, Tomoyo Mikami, Tomohiro Takahashi, Chiho Minakawa, Fumihiro Yanbe, Toshiyuki Waki, Toru Nakayama, et al. Biosynthesis of unnatural polyisoprenes by engineered prenyltransferases on rubber particles. 2024
Kohei Takeshita, Naoki Sakai, Go Ueno, Midori Horie, Hirofumi Tsujino, Mitsuhiro Arisawa, Masaki Yamamoto, Masayoshi Arai, Taku Yamashita. A large pocket structure surrounding the catalytic center in the BCG protein fromMycobacterium tuberculosis. 2024
Toshiyuki Waki, Riki Imaizumi, Kaichi Uno, Yamato Doi, Misato Tsunashima, Sayumi Yamada, Ryo Mameda, Shun Nakata, Taro Yanai, Kohei Takeshita, et al. Structural insights into catalytic promiscuity of chalcone synthase from Glycine max (L.) Merr.: Coenzyme A-induced alteration of product specificity. Biochemical and Biophysical Research Communications. 2024. 150080-150080
Riki Imaizumi, Hiroaki Matsuura, Taro Yanai, Kohei Takeshita, Shuto Misawa, Haruhiko Yamaguchi, Naoki Sakai, Yukino Miyagi-Inoue, Miki Suenaga-Hiromori, Toshiyuki Waki, et al. Structural-Functional Correlations between Unique N-terminal Region and C-terminal Conserved Motif in Short-chain cis-Prenyltransferase from Tomato. ChemBioChem. 2024
Hiroaki Matsuura, Naoki Sakai, Sachiko Toma-Fukai, Norifumi Muraki, Koki Hayama, Hironari Kamikubo, Shigetoshi Aono, Yoshiaki Kawano, Masaki Yamamoto, Kunio Hirata. Elucidating polymorphs of crystal structures by intensity-based hierarchical clustering analysis of multiple diffraction data sets. Acta Crystallographica Section D Structural Biology. 2023

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MISC (6)：

松浦滉明, 坂井直樹. New Applications of the High-Throughput Data Collection System at SPring-8 Macromolecular Crystallography Beamlines. 日本結晶学会誌. 2021. 63. 3
坂井直樹, 田中勲. 物質科学を変えた結晶学(8) タンパク質結晶学と創薬. 現代化学. 2014. 522. 54-55
田中勲, 渡邉信久, 姚閔, 坂井直樹. 特集タンパク 3000 プロジェクトの産んだもの第 I 部成果とインパクト:個別的解析拠点の研究成果転写・翻訳翻訳系蛋白質を中心に. 蛋白質核酸酵素. 2008. 53. 5. 608-611
坂井直樹, 田中勲. クローズアップ実験法結晶構造解析用試料の調製と結晶化 1. 大腸菌を用いた結晶化用試料の調製. 実験医学. 2007. 25. 11. 1727-1732
坂井直樹. 構造生物学を支えるハイスループット蛋白質生産. 化学と生物. 2005. 43. 11. 702-704

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Education (3)：

2000 - 2003 Hokkaido University
1998 - 2000 Hokkaido University
1994 - 1998 Hokkaido University School of Science Biological Sciences

Professional career (1)：

Master's degree (Hokkaido University, Mar. 2000), Doctor's degree (Hokkaido University, Mar. 2003) (Hokkaido University)

Work history (10)：

2023/04 - 現在 Japan Synchrotron Radiation Research Institute Structural Biology Division Senior scientist
2022/04 - 2023/03 Japan Synchrotron Radiation Research Institute Structural Biology Division Research Scientist
2018/10 - 2022/03 RIKEN RIKEN SPring-8 Center Research Scientist
2018/04 - 2018/09 RIKEN Center for Biosystems Dynamics Research Research scientist
2015/04 - 2018/03 RIKEN Center for Life Science Technologies Research scientist

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Committee career (1)：

2022/10 - 2024/09 The Japanese Society for Synchrotron Radiation Research Editorial committee

Association Membership(s) (3)：

The Crystallographic Society of Japan , The Japanese Society for Synchrotron Radiation Research , Protein Science Society of Japan

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