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J-GLOBAL ID：200901077651239975 Update date: Mar. 26, 2025

Tanuma Nobuhiro

タヌマノブヒロ | Tanuma Nobuhiro

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Affiliation and department：
Job title： Division Head
Other affiliations (1)：

Tohoku University Graduate School of Medicine

Homepage URL (1)： http://www.med.tohoku.ac.jp/about/laboratory/157.html

Research field (3)： Tumor diagnostics and therapeutics , Tumor biology , Molecular biology

Research keywords (6)：腫瘍学 , がん代謝 , 分子生物学 , 細胞生物学 , Molecular biology , Cellular biology

Research theme for competitive and other funds (41)：

2022 - 2025 腫瘍細胞のグルコース代謝と免疫シグナルの相互作用
2021 - 2024 卵巣がんの代謝脆弱性をターゲットする新規治療
2021 - 2023 栄養学的アプローチによる腫瘍免疫の賦活メカニズムと治療応用
2021 - 2023 高悪性がんにおける「エネルギー産生/NADホメオスタシス」相互依存からの脱却
2019 - 2022 A novel molecularly-targeted therapy for IDH-mutant gliomas.

2019 - 2022 The yin and yang of the Warburg effect of tumors.

2018 - 2021 Metabolisms in BRCA-deficient and -proficient ovarian cancer as new therapeutic and diagnostic target.

2017 - 2020 Tageting the PKM1-NAD metabolic axis in small cell lung cancer

2017 - 2019 Molecular mechanisms by which PKM1, reversing the Warburg effect, promotes tumor cell growth.

2016 - 2019 Targeting metabolic reprograming during therapy-induced cellular senescence in tumor cells.

2016 - 2017 Active glucose metabolism and tumor promotion mediated by Pkm1

2015 - 2017 Aerobic glucose metabolism and Pkm1 in small cell lung cancer.

2014 - 2017 Identification of PKM as a target for pancreatic cancer therapy

2014 - 2016 Possible interplay between metabolism and genomic instability during epithelial oncogenesis

2013 - 2016 Analysis of human samples for developing a novel therapy that target the Warburg effect

2013 - 2015 Roles for pyruvate kinase M in metabolic rewiring during gliomagenesis

2013 - 2015 Fluorescent live-imaging of the switching of pyruvate kinase isoforms during tumorigenesis

2012 - 2015 Roles for pyruvate kinase M in tumorigenesis

2012 - 2014 Possible interdependence between Warburg effect and genomic instability during colorectal cancer development

2011 - 2012 Aberrant pre-mRNA splicing that contributes to increased glycolysis in glioma

2011 - 2012 Development of novel therapy targeting the Warburg effect of cancer

2010 - 2012 癌のワールブルグ効果に関連するスプライシング異常の意義と機序

2010 - 2012 Aberrant pre-mRNA splicinginvolved in increased fluxof glycolysis in non-small lung cancer

2010 - 2011 Clinical importance of aberrant splicing of pre-mRNA encoding a glycolytic enzyme in colorectal cancer and its potential for diagnostic marker

2009 - 2010 解糖系異常亢進を惹起する肺癌特異的スプライシングスイッチング-新規診断法の開発-

2008 - 2010 Therapeutic effect of the polymeric micellar antineoplastic drugs infused convection-enhanced delivery against intracranial rat glioma models

2007 - 2009 Development of genetic diagnosis and drugs for lung cancer, based on protein phosphatase targeting

2007 - 2008 Regulation of cell function by protein phosphatases

2005 - 2006 遺伝子発現の転写後調節におけるプロテインホスファターゼPP1の役割

2005 - 2006 mRNA翻訳効率に対する転写過程での刷り込み現象

2004 - 2006 Regulation of cell function by protein dephosphorylation

2002 - 2005 Molecular mechanisms and their significance of protein phosphatase families which control the network-system of signal transduction

2003 - 2003 チロシンホスファターゼPTPεCのがん抑制機構

2002 - 2003 チロシンホスファターゼによるサイトカインシグナル伝達の抑制機構

2002 - 2003 Regulation of translation by protein phosphorylation.

2002 - 2002 チロシンホスファターゼPTPεCのがん関連分子としての意義の解明

2001 - 2001 発生やがん化に及ぼす内因性Jak-STAT阻害性ホスファターゼPTPεCの役割

2000 - 2001 Regulatgion of translation by protein phosphorylation.

1998 - 2001 Studies on control mechanism of protein phosphatases ds a network system of information

タンパク質リン酸化とタンパク質脱リン酸化酵素の研究

Study on protein phosphorylation and protein phosphatases

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Papers (45)：

Shuko Miyahara, Mai Ohuchi, Miyuki Nomura, Eifumi Hashimoto, Tomoyoshi Soga, Rintaro Saito, Kayoko Hayashi, Taku Sato, Masatoshi Saito, Yoji Yamashita, et al. FDX2, an iron-sulfur cluster assembly factor, is essential to prevent cellular senescence, apoptosis or ferroptosis of ovarian cancer cells. The Journal of biological chemistry. 2024. 300. 9. 107678-107678
Mai Ito, Nobuhiro Tanuma, Yui Kotani, Kokoro Murai, Ayumi Kondo, Mami Sumiyoshi, Hiroshi Shima, Satoshi Matsuda, Toshio Watanabe. Oncogenic K-Ras^G12V cannot overcome proliferation failure caused by loss of Ppp6c in mouse embryonic fibroblasts. FEBS Open Bio. 2024
Nomura, M, Oh-uchi, M, Sakamoto, Y, Kudo, K, Yaku, K, Soga, T, Sugiura, Y, Morita, M, Hayashi, K, Miyahara, S, et al. Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma. Nat. Commun. 2023. 14. 1. 8095-8095
宮原周子, 野村美有樹, 大内麻衣, 林佳代子, 山下洋二, 徳永英樹, 島田宗昭, 山田秀和, 田沼延公. 鉄硫黄クラスター生合成に異常をきたした細胞の表現型. 日本生化学会大会プログラム・講演要旨集. 2023. 96回. [1P-198]
宮原周子, 野村美有樹, 山下洋二, 田沼延公. 鉄硫黄クラスター生合成欠損が卵巣癌細胞株にもたらす、細胞老化様の増殖停止(Loss of Fe-S cluster biosynthesis causes senescence-like growth arrest in ovarian cancer cells). 日本癌学会総会記事. 2023. 82回. 410-410

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MISC (30)：

松永哲郎, 井田智章, 魏范研, 澤智裕, 守田匡伸, 西村明, 笠松真吾, 田沼延公, 藤井重元, 島礼, et al. システイニルtRNA合成酵素によるミトコンドリア機能制御の解明. 日本酸化ストレス学会学術集会プログラム・抄録集. 2017. 70th. 124
横山美沙, 渋谷莉恵, 坂本良美, 田沼延公, 望月麻衣, 中村真央, 玉井恵一, 山口壹範, 田中伸幸, 菅村和夫, et al. ピルビン酸キナーゼM2(PKM2)と膵癌細胞増殖. 膵臓. 2016. 31. 3. 547-547
渡邊利雄, 小河穂波, 田沼延公, 早川夏姫, 住吉麻実, 岸本綾子, 松居靖久, 鈴木麻衣, 佐々木希, 大内司, et al. ホスファターゼ研究のカティングエッジメディカルイノベーションへの橋渡しを目指して脱リン酸化酵素PP6の触媒サブユニットのPpp6cは着床後の胚の正常な発生に不可欠である. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015. 88回・38回. [4W6-p
横山美沙, 渋谷莉恵, 坂本良美, 田沼延公, 望月麻衣, 中村真央, 玉井恵一, 田中伸幸, 山口壹範, 菅村和夫, et al. ピルビン酸キナーゼM2(PKM2)と膵癌細胞増殖. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015. 88回・38回. [2P1096]-[2P1096]
松田俊, 足立淳, 井原賢, 田沼延公, 島礼, 垣塚彰, 井倉正枝, 井倉毅, 松田知成. ピルビン酸キナーゼとピルビン酸デヒドロゲナーゼ複合体によるアセチルCoAの地産地消モデル. 日本生化学会大会(Web). 2015. 88th

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Books (1)：

Cytoplasmic and transmembrane forms of PTP ε are generated from a single gene by use of different promoters. (jointly worked)
Kinases and Phosphatases in Lymphocyte and Neuronal Signaling, H. Yakura ed. , Springer-Verlag press. 1997

Education (5)：

1998 - 2001 北海道大学大学院理学研究科博士後期課程化学専攻
- 2001 北海道大学大学院理学研究科化学専攻
- 2001 Hokkaido University Graduate School, Division of Natural Science
- 1996 Hokkaido University School of Science
- 1996 Hokkaido University Faculty of Science

Professional career (1)：

- (Hokkaido University)

Work history (5)：

2022/10 - 現在東北大学大学院医学系研究科腫瘍生化学分野(連携講座) 教授(客員)
2022/04 - 現在 Miyagi Prefectural Hospital Organization Miyagi Cancer Center Division Head
2009/04 - 現在宮城県立がんセンター研究所主任研究員
2006/11 - 2009/03 宮城県立がんセンター研究所研究員
2001/04 - 2006/10 Hokkaido University Institute for Genetic Medicine

Committee career (1)：

2017/11 - 現在日本癌学会評議員

Association Membership(s) (4)：

がんと代謝研究会 , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , 日本癌学会 , 日本生化学会

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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