Yazawa Takuya

2020 - 2023 Basic research to elucidate the occurrence of inhomogeneity of transpulmonary pressure and to establish an individual ventilatory strategy for different pathological lungs.

2018 - 2021 Molecular basis of neuroendocrine lung carcinogenesis in association with dysfunction of RB1-family proteins

2017 - 2020 Clarification of precondition causing direct reprogramming in lung cancer

2015 - 2019 Progressive multifocal leukoencephalopathy: Dynamics of PML-NBs of JC virus-infected glial cells

2015 - 2018 Establishment of novel therapeutic strategy against neuroendocrine lung cancer through regulation of malignant neural phenotype

2015 - 2018 MOLECULAR PATHOLOGY ON FOLLICULIN GENE ABNORMALITIES AND TUMORIGENESIS OF VARIOUS ORGANS

2014 - 2017 A basic research to elucidate the mechanism of preconditioning against ischemia-reperfusion injury and its therapy

2013 - 2016 Lung protective strategy by the gene delivery of lung epitherial grow factor.

2012 - 2015 Dynamics of PML-NBs and potential oncogenecity in JC virus-infected cells

2012 - 2015 Molecular pathological analyses of proneural/neuroendocrine phenotype-obtaining mechanisms on lung cancer cells

2011 - 2013 The molecular basis of morphological atypism (proteome analysis of KRAS downstream factors)

2011 - 2013 A diversified approach to investigate the mechanism of acute lung injury and to establish its therapeutic strategy

2010 - 2012 Therapeutic approach to lung cancer and malignant mesothelioma by inhibition of VEGR-VEGFR pathway

2009 - 2011 Analysis of expression mechanisms of neuroendocrine cancer cell-specific molecules via TTF-1

2009 - 2011 Gene transduction of VEGF(vascular endothelial growth factor) receptor2 for intestine ischemia reperfusion induced lung injury.

2008 - 2010 Analysis of Intra-cellular signaling pathway and gene network in acute lung injury as for therapeutic strategy.

2007 - 2008 Exhaustive search for onco-suppressor genes induced by Egr-1 and cause-analysis of their repression in association with carcinogenesis

2007 - 2008 Prevention of acute lung injury after liver ischemia-reperfusion

2006 - 2007 Basic research on gene therapy by pulmonary epithelial cell growth factor on acute and chronic lung injury

2006 - 2007 肺小細胞癌において高発現するインスリン様増殖因子結合蛋白2の発現機序及び機能解析

2002 - 2003 Establishment of tumor immunotherapy using class II

2001 - 2002 Significance of Notch signaling in cell fact determination of lung

1999 - 2000 Molecular analysis on deficient class II transactivator expression in neuroendocrine cancers

1999 - 2000 Class II transactivator強制発現による抗腫瘍免疫療法の研究

1998 - ヒト肺腺癌発生のメカニズムの解明

1998 - Study on oncogenesis on human lung epithelium

1995 - 1995 ヒト肺癌培養細胞におけるMHCクラスII抗原・Invariant鎖の発現と局在

1994 - 1994 ヒト肺癌培養細胞におけるMHC class ||抗原発現状態の組織型差異の原因解明

1988 - 免疫関連遺伝子導入による抗腫瘍免疫療法の研究

1988 - Study on anti-cancer immunity using transfection of immune related genes