Research field (5):
Genomics
, Hematology and oncology
, Pathobiochemistry
, Molecular biology
, Tumor biology
Research keywords (7):
Animal disease model
, Genome study
, Tumor immunity
, Cancer-related gene
, Metastasis
, Cancer
, stem cell
Research theme for competitive and other funds (13):
2023 - 2026 Developing a pneumoconiosis atlas at the single-cell resolution
2022 - 2025 Elucidation of the molecular basis of MYC-driven cancers and development of therapeutic strategies
2021 - 2024 Evaluation of minimal residual disease by liquid biopsy in malignant lymphoma for precise therapeutic stratification.
2022 - 2024 急性骨髄性白血病の治療抵抗性におけるMYCの役割
2020 - 2023 新規シングルセル解析法を用いたじん肺発症-進展における包括的基盤研究
2019 - 2022 A comprehensive genomic analysis of central nervous system germ cell tumors and generation of their cellular model
2018 - 2021 Myc誘導性リンパ腫における増悪化機構の統合的解明と制御
2015 - 2018 Elucidation of molecular mechanism of immune evasion in malignant lymphoma
2015 - 2016 Analysis of escaping mechanism from immune system by microenvironment of cancer stem cells
2013 - 2015 Analysis of mature B cell lymphomagenes by mutated epigenetic factors
2013 - 2014 高分化型リンパ腫モデルの構築及び新規抗がん剤標的分子の同定
2011 - 2012 Analysis of CD44 role in metabolism of leukemic stem cell
2004 - 2006 MYCNによるMitotic catastrophe誘導の解析
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Papers (79):
Keiko Fujisaki, Shogo Okazaki, Shuhei Ogawa, Miyama Takeda, Eiji Sugihara, Kenichi Imai, Seiya Mizuno, Satoru Takahashi, Ryo Goitsuka. B Cells of Early-life Origin Defined by RAG2-based Lymphoid Cell Tracking under Native Hematopoietic Conditions. Journal of immunology (Baltimore, Md. : 1950). 2024
Shin Kasai, Minori Tamai, Eiji Sugihara, Naoki Oishi, Kyoko Hinata, Koshi Akahane, Kumiko Goi, Yuko Hata, Tetsuo Kondo, Takahiko Mitsui, et al. In utero tumor development and identification of CTNNB1 mutation in a newborn case of ossifying renal tumor of infancy. Pediatric blood & cancer. 2024. e30868
今枝 慶蓉, 増田 健太, 永井 晋平, 田村 友宏, 杉原 英志, 山崎 淳太郎, 大槻 雄士, 信末 博行, 千代田 達幸, 小林 佑介, et al. 新規マウスモデルを用いた高異型度漿液性癌の予後不良に関連するバイオマーカーの同定(Identification of biomarkers associated to poor prognosis in high-grade serous carcinoma using novel mouse models). 日本癌学会総会記事. 2023. 82回. 1044-1044
Hisako Ichihara, Manabu Yamada, Mitsuyo Kohara, Hideki Hirakawa, Andrea Ghelfi, Takuro Tamura, Akihiro Nakaya, Yasukazu Nakamura, Sachiko Shirasawa, Samatchaya Yamashita, et al. Plant GARDEN: a portal website for cross-searching between different types of genomic and genetic resources in a wide variety of plant species. BMC plant biology. 2023. 23. 1. 391-391
Atsuko Sugimoto, Takahiro Watanabe, Kazuhiro Matsuoka, Yusuke Okuno, Yusuke Yanagi, Yohei Narita, Seiyo Mabuchi, Hiroyuki Nobusue, Eiji Sugihara, Masaya Hirayama, et al. Growth Transformation of B Cells by Epstein-Barr Virus Requires IMPDH2 Induction and Nucleolar Hypertrophy. Microbiology spectrum. 2023. e0044023
マウス卵管上皮オルガノイドを用いた新規卵巣癌マウスモデルの開発(Development of a new ovarian cancer mouse model by engineering mouse fallopian tube epithelial organoids)
(日本癌学会総会記事 2022)
当院における院内がんゲノム検査の運用と課題
(医療検査と自動化 2022)
Improvement of a plant genome information portal site, Plant GARDEN (2021・Q4 ver)
(育種学研究 2022)
2017 - Japanese Society of Hematology Research grant in 2017
2017 - 公益信託 白血病研究基金 一般研究賞 受賞
2017 - 公益財団法人 がんの子どもを守る会 研究助成金受賞
2016 - Workshop of Cancer Animal Model Outstanding Oral Presentation Award
2015 - European Hematology Association Annual Meeting Travel Award
2008 - Keio University COE Program Young Researcher Award
2003 - Young Researchers Society for Biochemistry Investigating Award
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Association Membership(s) (5):
The American Society of Hematology
, American Assciation of Cancer Research
, THE JAPANESE SOCIETY OF HEMATOLOGY
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, THE JAPANESE CANCER ASSOCIATION