Rchr
J-GLOBAL ID:200901078764083099
Update date: Feb. 11, 2025 Ayako Wakabayashi
ワカバヤシ アヤコ | Ayako Wakabayashi
Affiliation and department: Job title:
Senior Assistant Professor
Research field (1):
Immunology
Research keywords (5):
Immunology
, Mucosal Immunology
, allergy
, gut microbiome
, Food Hygiene
Research theme for competitive and other funds (20): - 2024 - 2028 ヒト好酸球性鼻副鼻腔炎病態でのtype2炎症と腸内カンジダ増殖の関連についての研究
- 2022 - 2026 Analysis of intestinal bacterial invasion into intestinal epithelial cells and inflammation induction by an aluminum-containing food additive alum
- 2024 - 2025 共役リノール酸を高めた乳あるいは肉の生産およびその摂取による肥満の改善
- 2024 - 2025 カスパーゼ-1およびカスパーゼ-11阻害剤による腸上皮細胞死の抑制と腸管2型炎症の改善の検討
- 2021 - 2025 イヌの肝細胞癌のオルガノイドバンクの構築および新規治療法の開発
- 2023 - 2023 A food additive containing aluminum causes cleavage of interleukin-33 and gasdermin D in intestinal epithelial cells under antibiotic treatment
- 2019 - 2023 好酸球性副鼻腔炎病態への腸内フローラ、カンジダ増殖関与についての予備的研究
- 2021 - 2023 抗生剤が促進する食品添加物ミョウバンによる腸管上皮の炎症性細胞死の解析
- 2019 - 2023 Release of damage-associated molecular patterns from intestinal epithelia by aluminum salt and involvement in the development of food allergy
- 2017 - 2023 Gut microbiotaの制御が脳虚血病巣進展および神経機能に及ぼす影響
- 2021 - 2022 食品添加物ミョウバン刺激後に腸上皮細胞に侵入して炎症性細胞死を誘導する腸内マイクロバイオームへ抗生剤が与える影響の16S rRNAメタゲノム解析
- 2020 - 2022 腸内細菌叢および腸管上皮細胞からのDAMPs制御による脳虚血病巣進展への影響
- 2019 - 2022 ミョウバンによる腸管上皮損傷に伴う炎症・アレルギー誘導性損傷関連分子の放出の解析と免疫学的安全性評価の検討
- 2020 - 2020 食品添加物ミョウバンによるマウス腸上皮細胞インフラマソーム活性化のトランスクリプトーム解析
- 2015 - 2019 Damage-associated molecular pattern released from intestinal epithelia damaged by bacterial exotoxin induces food allergy
- 2012 - 2015 Activation of dendritic cells and induction of ovalbumin-specific allergic responses by irradiation
- 2009 - 2011 Induction of ovalbumin-specific allergic reaction by ingestion of food additives including aluminum
- 2006 - 2008 Induction of ovalbumin ?specific immune responses by oral administration of residual chlorine : chlorine and food allergy
- 2008 - 経口ワクチンによる抗腫瘍免疫誘導法の研究
- 2002 - 2003 腸内の細菌外毒素が卵白アルブミン特異的免疫反応に与える影響:毒素と食物アレルギー
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Papers (15): -
Ayako Wakabayashi, Masumi Shimizu, Eiji Shinya, Hidemi Takahashi. HMGB1 released from intestinal epithelia damaged by cholera toxin adjuvant contributes to activation of mucosal dendritic cells and induction of intestinal cytotoxic T lymphocytes and IgA. Cell death & disease. 2018. 9. 6. 631-631
- Ryosuke Murakami, Yohko Nakagawa, Masumi Shimizu, Ayako Wakabayashi, Yasuyuki Negishi, Takachika Hiroi, Kimihiro Okubo, Hidemi Takahashi. Effects of Dendritic Cell Subset Manipulation on Airway Allergy in a Mouse Model. International archives of allergy and immunology. 2015. 168. 4. 219-32
- Hirotomo Harimoto, Masumi Shimizu, Yohko Nakagawa, Katsuhisa Nakatsuka, Ayako Wakabayashi, Choitsu Sakamoto, Hidemi Takahashi. Inactivation of tumor-specific CD8+ CTLs by tumor-infiltrating tolerogenic dendritic cells. Immunology and cell biology. 2013. 91. 9. 545-55
- Yasuyuki Negishi, Ayako Wakabayashi, Masumi Shimizu, Tomoko Ichikawa, Yoshihiro Kumagai, Toshiyuki Takeshita, Hidemi Takahashi. Disruption of maternal immune balance maintained by innate DC subsets results in spontaneous pregnancy loss in mice. Immunobiology. 2012. 217. 10. 951-61
- Keiichi Moriya, Ayako Wakabayashi, Masumi Shimizu, Hideto Tamura, Kazuo Dan, Hidemi Takahashi. Induction of tumor-specific acquired immunity against already established tumors by selective stimulation of innate DEC-205(+) dendritic cells. Cancer immunology, immunotherapy : CII. 2010. 59. 7. 1083-95
more... MISC (78): -
WAKABAYASHI Ayako, OWAKI Atsuko, IWATSUKI Ken, TODA Etsuko, NISHIYAMA Yasuhiro, MATSUNE Shoji, MORITA Rimpei. An aluminum-containing food additive causes cleavage of IL-18, IL-33 and gasdermin D in intestinal epithelial cells under antibiotic treatment. 日本免疫学会総会・学術集会記録(CD-ROM). 2024. 52
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若林あや子. ミョウバンによる腸管上皮損傷に伴う炎症・アレルギー誘導性損傷関連分子の放出の解析と免疫学的安全性評価の検討. 日本食品化学研究振興財団 第28回(令和3年度)研究成果報告書. 2022. 28. 57-62
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若林あや子, 森田林平, 岩槻健, 隈本宗一郎. 食品添加物ミョウバン刺激後に腸上皮細胞に侵入して炎症性細胞死を誘導する腸内マイクロバイオームへ抗生剤が与える影響の16S rRNAメタゲノム解析. 東京農業大学生物資源ゲノム解析拠点ニュースレター. 2022. 9. 33
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若林あや子. Analysis of release of damage-associated molecular patterns involved in inflammation and allergy after intestinal epithelial damage by potassium aluminum sulphate and immunological safety evaluation. 日本食品化学研究振興財団研究成果報告書. 2021. 27. 110-120
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Increased inflammatory cell death in intestinal epithelial cells by oral administration of aluminum salt as a food additive. 2021. 70. 6-7. 742
more... Lectures and oral presentations (91): -
Low-dose heparin calcium inhibits cleavage of caspase-1, caspase-11, IL-33, and gasdermin D in intestinal epithelial cells
(2024)
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A caspase-1 inhibitor inhibits cell death of intestinal epithelial cells caused by an aluminum-containing food additive under antibiotic treatment
(第73回日本アレルギー学会学術大会 2024)
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低量ヘパリンカルシウムは腸上皮炎症性細胞死を抑制して好酸球浸潤を改善する
(第 92 回日本医科大学医学会学術集会 2024)
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食品添加物ミョウバンを与えたマウス腸上皮細胞のトランスクリプトーム解析と16S rRNAアンプリコン解析による炎症性細胞死機構の解明
(東京農業大学 生物資源ゲノム解析拠点研究報告会 2024)
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An aluminum-containing food additive causes cleavage of IL-18, IL-33 and gasdermin D in intestinal epithelial cells under antibiotic treatment
(The 52nd Annual Meeting of The Japanese Society for Immunology 2024)
more... Professional career (1): - Ph.D (Tokyo Medical and Dental University)
Work history (7): - 2016 - 現在 Nippon Medial School Department of Microbiology and Immunology Senior Assistant Professor
- 2001 - 現在 Japan Women’s University Adjunct Asistant Professor
- 2007 - 2016 Nippon Medical School Department of Microbiology and Immunology Assistant Professor
- 1999 - 2007 Nippon Medical School Department of Microbiology and Immunology Research Associate
- 1997 - 1999 Japan Foundation for Aging and Health Research Resident
- Nippon Medical School
- Nippon Medical School Department of Microbiology and Immunology Senior Assistant Professor
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Committee career (2): - 2019/04 - 現在 学校法人日本医科大学しあわせキャリア支援センター 委員
- 2015/04 - 2019/03 日本医科大学法人本部女性医師・研究者支援室 室員
Awards (2): - 2019/04 - 公益財団法人日本食品化学研究振興財団助成金 ミョウバンによる腸管上皮損傷に伴う炎症・アレルギー誘導性損傷関連分子の放出の解析と免疫学的安全性評価の検討
- 2008 - Nippon Medical School The Award in Maruyama's memory
Association Membership(s) (3):
JAPANESE SOCIETY OF ALLERGOLOGY
, JAPAN SOCIETY OF NUTRITION AND FOOD SCIENCE
, THE JAPANESE SOCIETY FOR IMMUNOLOGY
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