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J-GLOBAL ID：200901080094567450 Update date: Apr. 08, 2025

Kakita Akiyoshi

カキタアキヨシ | Kakita Akiyoshi

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Affiliation and department：
Job title： Professor

Research field (1)： Neuroanatomy and physiology

Research theme for competitive and other funds (47)：

2023 - 2026 ひとてんかん原性病態機序を知りこれを制御する
2023 - 2026 自己免疫性グリア病における免疫細胞由来「細胞外DNAトラップ」の生物学的意義の解明
2024 - 2025 認知症治療標的としてのミクログリアによるアストロサイト制御機構に剖検脳から迫る
2022 - 2025 認知症治療標的としてのミクログリアによるアストロサイト制御機構に剖検脳から迫る
2022 - 2025 神経病原性蛋白質オリゴマーの神経毒性を抑制する分子メカニズム

2021 - 2025 Chemo-sensitization of brain tumors by manipulation of SLFN11

2021 - 2024 Visualization of microenvironments of malignant glioma utilizing 7T-MRI and 3D tissue clearing technology

2020 - 2023 自己免疫性グリア病における時空間的免疫制御によるneural repairの研究

2020 - 2022 Digital 3D Neuropathology: Methodological Platform Creation

2019 - 2022 Microglia-astrocyte crosstalk in leukoencephalopathies

2019 - 2022 Comprehensive epileptic network analysis in human brain by neuron and glia

2019 - 2022 Ex vivo optical imaging of human brain tissues for visualization of epileptogenic networks.

2019 - 2022 Mechanism of inactivation of neuropathogenic protein toxicity by aggresomes

2019 - 2022 Pathomechanisms and Control of Epileptogenic Foci: Imaging Practices for Surgical Specimens

2019 - 2022 Mechanisms of lesion formation in Parkinson's disease: an analysis using tissue clearing and 3D observation

2017 - 2022 Visualization of epileptogenic foci of MRI non-lesional neocortical epilepsy patients by 7T-MRI

2016 - 2019 Microglial involvement in the pathomechanisms of white matter degeneration

2016 - 2019 Stages of glial inclusion pathology in multiple system pathology

2015 - 2019 On the transneuronal propagation in neurodegenerative diseases

2016 - 2018 A feasibility study for 3D neuropathology

2015 - 2018 Development of a preoperative highly accurate evaluation method to detect epileptic foci -Analyzing high frequency oscillations with dense array EEG-

2015 - 2018 Epileptogenesis in Mesial Temporal Lobe Epilepsy

2014 - 2017 Amyotrophic Lateral Sclerosis and TDP-43: Elucidation of molecular neuropathology in terms of spread from its beginning

2013 - 2017 Pathomechanisms underlying human temporal lobe epilepsy

2012 - 2017 Cytokine-Induced Neuropathologic Endophenotypes of Psychiatric Diseases

2013 - 2016 Regulation of neuronal cell size control in normal and disease condition

2013 - 2016 Autoreguation of TDP-43 in ALS

2013 - 2015 Pathogenesis of focal cortical dysplasia: possible mechanistic implification of somatic mutations

2010 - 2015 Personal genome analysis on Alzheimer's disease

2011 - 2014 A study on the molecular mechanisms of neurodegeneration induced by high-mass amyloid-beta assembly, amylospheroids (ASPD)

2011 - 2014 ALS and TDP-43: Dose the splicing failure underlie the pathogenesis of ALS?

2009 - 2014 Magnetic Resonance Molecular Microimaging

2010 - 2012 Molecular pathogenesis of ALS: approach from TDP-43 function.

2010 - 2011 Clarification of epileptogenicity using human brain slices in vitro

2009 - 2011 Spatiotemopral dynamics of epiletiform propagations in surgical specimens taken from patients with intractable epilepsy

2008 - 2010 Amyotrophic lateral sclerosis and TDP-43 : elucidation of the entire neuropathological picture and molecular pathomechanism

2005 - 2009 Comparative Transcriptome Study of Brain

2007 - 2008 Epileptogenic mechanisms underlying cortical lesions in patients with intractable seizures

2004 - 2006 Tracing of regenerating nerve along its length using adenovirus vector

2004 - 2005 内在性相補鎖RNAによる遺伝子発現調節機構に注目したシヌクレイン関連蛋白の解析

2004 - 2005 Molecular mechanisms underlying progenitor migration following methylmercury exposure in the developing brain

2001 - 2005 脳内サイトカインによる中枢神経機能の制御メカニズム:分子から精神活動へ

2003 - 2004 難治てんかん原性病巣としての「皮質形成異常」の分子病理学的診断基準の確立

2002 - 2003 Migration pathways and fate determination of progenitors in the subventricular zone

2000 - 2002 A study on the molecular pathomechanisms underflying intractable epilepsy

2000 - 2001 Investigation on migration mechanisms of glial progenitors: observations of living cells labeled by dual fluorescent molecules

1996 - 1996 ニューロブラストの産生および移動の障害に基づく脳奇形の形成機序に関する研究

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Papers (731)：

Kazuki Tainaka, Tatsuya C. Murakam, Etsuo A. Susaki, Chika Shimizu, Rie Saito, Kei Takahashi, Akiko Hayashi-Takagi, Hiroshi Sekiya, Yasunobu Arima, Satoshi Nojima, et al. Chemical Landscape for Tissue Clearing based on Hydrophilic Reagents. Cell Reports. 2108. 24. 8. 2196-2210
Akihiro Nakajima, Mariko Hokari, Fumihiro Yanagimura, Etsuji Saji, Hiroshi Shimizu, Yasuko Toyoshima, Kaori Yanagawa, Musashi Arakawa, Akiko Yokoseki, Takahiro Wakasugi, et al. Long-Term Clinical Landscapes of Spinal Hypertrophic Pachymeningitis With Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis. Neurology. 2025. 104. 8
Yosuke Ito, Masafumi Fukuda, Ken Ohno, Tomoyoshi Ota, Masaki Watanabe, Tsuyoshi Matsuda, Masahiro Hatakeyama, Hiroshi Masuda, Hiroki Kitaua, Akiyoshi Kakita, et al. Visualizing epileptogenic regions using the chemical exchange saturation transfer method in a patient with drug-resistant focal epilepsy: a case report. Journal of Medical Case Reports. 2025. 19. 1
Shoichiro Ando, Rie Saito, Sho Kitahara, Masahiro Uemura, Yuya Hatano, Masaki Watanabe, Taisuke Kato, Yosuke Ito, Atchayaram Nalini, Tomohiko Ishihara, et al. “Chocolate Chip Sign” on Susceptibility-Weighted Imaging. Neurology Genetics. 2025. 11. 2
Shoko Hongo, Tetsuhiko Ikeda, Mari Tada, Rina Aida, Tetsuo Ozawa, Norikazu Hara, Akinori Miyashita, Takashi Nakajima, Osamu Onodera, Takeshi Ikeuchi, et al. Novel Aspects of Hereditary Spastic Paraplegia: A Clinicopathologic and Biochemical Study of a Patient With a Heterozygous GCH1 Variant. Neuropathology and applied neurobiology. 2025. 51. 1. e70006

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MISC (312)：

木崎利哉, 金澤雅人, 石黒敬信, 棗田学, 岡本浩一郎, 大石誠, 柿田明美, 藤井幸彦, 小野寺理. 非腫瘍性疾患における脳生検の適応決定に有用な画像所見. 日本神経学会学術大会プログラム・抄録集. 2024. 65th
宮下哲典, 大日方藍, 他田真理, 阿部学, 柿田明美, 池内健. Search for APOE rare missense variants in a Japanese population. Bio Clinica. 2024. 39. 4
小柳清光, 橋本智代, 和田学, 山崎峰雄, 中原亜紗, 柿田明美. 【ALS-どこまでわかり,どこまで治るか】総論グアム島と西ニューギニアのALSとPDCとは何であり,医学はそれらから何を学んだのか. Clinical Neuroscience. 2023. 41. 3. 325-329
宍戸理紗, 日野瑞城, 日野瑞城, 長岡敦子, 長岡敦子, 林秀樹, 柿田明美, 三浦至, 富田博秋, 國井泰人, et al. Expression changes in molecules related to DNA double-strand break repair in a high stress response group of schizophrenia. 日本生物学的精神医学会(Web). 2023. 45th
細貝優人, 日野瑞城, 日野瑞城, 宍戸理紗, 長岡敦子, 長岡敦子, 林秀樹, 柿田明美, 富田博秋, 三浦至, et al. Gene expression analysis of ZDHHC family of protein S-palmitoylating enzymes in postmortem brains of patients with schizophrenia. 日本生物学的精神医学会(Web). 2023. 45th

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Books (23)：

非定型パーキンソニズムー基礎と臨床ー
文光堂 2019 ISBN:9784830615474
ペランパネルによるてんかんの治療ストラテジー
先端医学社 2019 ISBN:9784865503777
カラーアトラス病理組織の見方と鑑別診断.第6版
医歯薬出版 2018 ISBN:9784263731857
てんかん学用語事典
診断と治療社 2017 ISBN:9784787823410
脳腫瘍臨床病理カラーアトラス第4版
医学書院 2017 ISBN:9784260030472

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Lectures and oral presentations (99)：

中枢神経病理:コアイメージ・キーワード
(日本神経学会 2019)
脳神経神経変性疾患:病理学的解析のポイント
(日本病理学会 2019)
てんかん原性脳病巣の病態病理:外科標本の解析から
(第42回日本てんかん外科学会 2019)
難治てんかん原性病巣の病態病理:外科手術標本を用いた解析
(大阪大学セミナー 2018)
PATHOLOGIC FEATURES OF GLIA IN PATIENTS WITH DEMENTIA:
(KBRI-NBRI symposium 2018)

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Professional career (1)：

博士(医学) (新潟大学)

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