Rchr
J-GLOBAL ID：200901081297049486
Update date: Jul. 07, 2024
Sato Takeya
サトウ タケヤ | Sato Takeya
Affiliation and department：
Job title：
Associate Professor
Homepage URL (1)：
https://www.med.tohoku.ac.jp/laboratory/view/118
Research field (4)：
Pharmacology
, Nutrition and health science
, Molecular biochemistry
, Biochemistry
Research keywords (5)：
Autophagy, Mitophagy
, Mitochondria
, cellular quality control
, Molecular and Cellular Pharmacology
, Cell Fate Control Gene and cell therapy
Research theme for competitive and other funds (25)：
- 2003 - 現在 Development of novel cell fate control gene therapy
- 2024 - 2027 Development of new treatment for colorectal cancer through improvement of mitochondrial function using indole compounds
- 2021 - 2024 Role of cytoskeletal protein 4.1G on bone formation and improvement in pathophysiology of osteoporosis
- 2019 - 2022 Action of general anesthetic on sarcopenia: analysis of the mechanism of impairment of autophagy of sarcopenia
- 2018 - 2021 Elucidation of mechanisms of bone formation; primary ciliary formation by protein 4.1G
- 2018 - 2021 Elucidation of the mechanism of drug-induced lethal cardiac myopathy; participation of autophagic process and the rab, intracellular membrane transport system
- 2015 - 2018 The molecular mechanism of drug induced mitochondrial dysfunction focused on mitochondrial quality control system
- 2014 - 2017 Molecular bases for intracellular trafficking and functional signalosome formation mediated through histamine H3 receptor
- 2012 - 2016 Elucidation of spatio-temporal regulation of the intracellular configuration of GPCR-signaling complex
- 2011 - 2013 Research on elimination of heterogenity of iPS cells that is believed to be causative in the tumor formation.
- 2010 - 2012 GPCRシグナル複合体細胞内輸送の時空間的制御に関する検討
- 2009 - 2011 Analysis of regulatory mechanisms of cell surface expression of G protein-coupled receptor signaling complex
- 2009 - 2011 Analysis of regulatory mechanisms of cell surface expression of Histamine H3 receptor
- 2008 - 2010 Clarify the molecular mechanisms of the induction of apoptosis by the highly active nucleosides
- 2009 - 2009 iPS細胞使用の安全装置としての「細胞運命制御遺伝子治療法」の有効性評価研究
- 2006 - 2007 Attempt of Cancer Pain Control with the aid of Anti-TRPV Channel Antibody
- 2003 - 2005 胆汁成分の新規処理機構の解明-胆道閉鎖症治療への応用を目指して-
- 2002 - 2004 A study on vitamin A storage in polar bears in Greenland.
- 2001 - 2004 a study on isolation and clonal expansion of the stem cell of hepatic stellate cells.
- 2003 - 2003 北欧極北民族における脂質関連がんの発生と環境・宿主要因の解明
- 2002 - 2002 北欧極北民族における脂質関連がんの発生と環境・宿主要因の解明
- 2001 - 2002 肝臓星細胞のビタミンA取り込みの分子機序の解明
- 2001 - 2001 北欧極北民族における脂質関連がんの発生と環境・宿主要因の解明
- 2000 - 2000 北欧極北民族における脂質関連がんの発生と環境・宿主要因の解明
- 1999 - 2000 Study on the mechanisms of vitamin A-storage in arctic animals
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Papers (61)：
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Kenji Sakaji, Sara Ebrahimiazar, Yasihiro Harigae, Ken-ichi Ishibashi, Takeya Sato, Takeo Yahikawa, Gen-ichi Atsumim Ching-Hwa Sung, Masaki Saito. MAST4 promotes primary ciliary resorption through phosphorylation of Tctex-1. Life Science Alliance. 2023. 6. 11. e202301947-e202301947
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Noriko Toda, Takeya Sato, Mikio Muraoka, Lin Delan, Masaki Saito, Guanje Li, Song Qui-Chao, Teruyuki Yanagisawa, Masanori Yamauchi. Doxorubicin induces cardiomyocyte death owing to the accumulation of dysfunctional mitochondria by inhibiting the autophagy fusion process. Free Radical Biology and Medicine. 2022. 195. 47-57
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Masaki Saito, Marina Hirano, Tomohiro Izumi, Yu Mori, Kentaro Ito, Yurika Saitoh, Nobuo Terada, Takeya Sato, Jun Sukegawa. Cytoskeletal Protein 4.1G Is Essential for the Primary Ciliogenesis and Osteoblast Differentiation in Bone Formation. International Journal of Molecular Sciences. 2022. 23. 4. 2094-2094
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Masaki Saito, Ayano Chiba, Takeya Sato, Takahiro Moriya, Jun Sukegawa, Norimichi Nakahata. Tctex-1 augments G protein-coupled receptor-mediated G(s) signaling by activating adenylyl cyclase. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2021. 145. 1. 150-154
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Masaki Saito, Linran Cui, Marina Hirano, Guanjie Li, Teruyuki Yanagisawa, Takeya Sato, Jun Sukegawa. Activity of Adenylyl Cyclase Type 6 Is Suppressed by Direct Binding of the Cytoskeletal Protein 4.1G. MOLECULAR PHARMACOLOGY. 2019. 96. 4. 441-451
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MISC (92)：
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Takeya Sato, Noriko Toda, Masaki Saito, Masanori Yamauchi, Takaaki Abe. Doxorubicin did not affect the lysosomal acidification. 2022
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佐藤岳哉, 村岡幹夫, 戸田法子, 戸田法子, 山内正憲, 斎藤将樹, 柳澤輝行. ドキソルビシンの心筋障害の分子機構-ミトコンドリア選択的オートファジー,ミトファジー障害による-. 日本薬理学雑誌. 2021. 156. Supplement
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EBRAHIMIAZAR Sara, 阪路健祐, 佐藤岳哉, 斎藤将樹. MAST4 accelerates primary ciliary resorption and cell cycle re-entry through activation of Cdc42. 日本薬理学雑誌. 2021. 156. Supplement
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斎藤将樹, 阪路健祐, AZAR Sara Ebrahimi, 佐藤岳哉. Tctex-1を介した一次繊毛の短縮・消失におけるCdc42の活性化機構. 日本生化学会大会(Web). 2020. 93rd
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佐藤岳哉, 斎藤将樹, 野村亮介, 助川淳. ミトコンドリア特異脂質カルジオリピンとミトコンドリア代謝に対する酸化ストレスの影響. 日本薬理学雑誌. 2020. 155. Supplement
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Patents (7)：
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腸疾患および腎疾患の診断方法
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ヒトグリセンチンのモノクローナル抗体、この抗体を産生するハイブリドーマおよびそれを用いるヒトグリセンチンの定量法
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グリセンチンの生産法
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免疫測定法
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変異型モニターペプチド
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Books (1)：
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Thee Pharmacological Basis of Therapeutics
2022 ISBN:9784567498036
Lectures and oral presentations (89)：
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抗ガン剤ドキソルビシンのオートファジー障害はリソソーム機能障害によるものでは無い
(日本薬理学会第96回年会 2022)
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ドキソルビシンはミトコンドリア呼吸を阻害することで致死的心筋ダメージを生ずる
(日本薬理学会第95回年会 2022)
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Tctex-1リン酸化を介した一次繊毛短縮と細胞増殖の分子制御機構
(日本生化学会東北支部 第87回例会 2021)
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Tctex-1はアデニル酸シクラーゼを活性化して副甲状腺ホルモン受容体のGsシグナルを増強する
(日本薬理学会第94回年会 2021)
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MAST4はCdc42の活性化を通して一次繊毛吸収と細胞周期再エントリーを促進する
(日本薬理学会第94回年会 2021)
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Education (3)：
- - 1996 University of Shizuoka Graduate School, Division of Pharmaceutical Sciences
- - 1989 Osaka University Graduate School, Division of Natural Science
- - 1987 Shizuoka University Faculty of Science 化学科
Professional career (1)：
- Doctor of pharmacy (University of Shizuoka)
Work history (5)：
- 2014/04 - 現在 Tohoku University Graduate School of Medicine Associate Professor
- 2005/10 - 2014/03 Tohoku University Graduate School of Medicine Assistant Professor
- 2003/08 - 2006/04 University of Toronto Postdoctral Fellow
- 1999/04 - 2003/07 秋田大学医学部 助手
- 1989/04 - 1999/03 日清製粉株式会社医薬研究所 研究員
Committee career (2)：
- 2006/07 - 現在 日本薬理学会 評議員
- 2021/07 - 2022/12 日本薬理学会第96回年会 プログラム編集委員
Awards (5)：
- 2022/03 - Japanese Society of Pharmacology Best reviewer of Journal of Pharmacological Sciences.
- 2021/03 - Tohoku University Graduate School of Medicine Educational Contribution Award
- 2019/03 - The Japanese Pharmacological Society Excellent Reviewer Award Excellent Reviewer Award
- 2009/09 - Research Award
- 2005/04/18 - Southern Ontario Gene therapy meeting best poster award of Southern Ontario Gene therapy meeting
Association Membership(s) (5)：
日本ミトコンドリア学会
, 日本遺伝子治療学会(2005/07-)
, American society of cell biology(2007/10-2008/10)
, American society of gene and cell therapy(2007/10-)
, 日本薬理学会(2006/07- 評議員)
