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J-GLOBAL ID：200901081715723083 Update date: Mar. 13, 2025

MASAHIRO KAWAHARA

カワハラマサヒロ | MASAHIRO KAWAHARA

Affiliation and department：
Job title： Professor

Research field (1)： Neuroscience - general

Research theme for competitive and other funds (21)：

2018 - 2022 Effects of metals on oligomerization, channel formation, and neurotoxicity of amyloidogenic proteins
2017 - 2021 Neural tissue array with blood brain barrier (BBB) for the drug screening assay
2014 - 2017 Neuroprotective mechanism of carnosine against zinc-induced neurotoxicity: a possible drug for vascular dementia
2009 - 2011 Molecular mechanism of zinc-induced neurotoxicity : involvement of Ca and ER stress
2008 - 2010 Development of the photochemical panning adapted to low affinity ligands and analysis of neural carbohydrates' functions

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Papers (156)：

Ken-Ichiro Tanaka, Yui Uehara, Mikako Shimoda, Rioko Funayama, Sachie Shiota, Akari Yamaguchi, Akio Sugimoto, Masaki Ichitani, Yoshito Kadota, Takashige Kawakami, et al. Metallothionein, an endogenous antioxidant protein, protects against acute lung injury caused by air pollutants. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2025. 185. 117965-117965
三谷彩佳, 舩山梨音子, 虎谷愛絵理, 木下玲野, 下田実可子, 川原正博, 濱進, 田中健一郎. ぶどう果皮の主成分が大気汚染肺傷害を予防する分子機構の解析. Biomedical Research on Trace Elements. 2024. 35. S1. 87-87
Masahiro Kawahara, Ken-Ichiro Tanaka, Midori Kato-Negishi. Zinc, Copper, and Calcium: A Triangle in the Synapse for the Pathogenesis of Vascular-Type Senile Dementia. Biomolecules. 2024. 14. 7
Saho Yuzawa, Motonari Nakashio, Suzuna Ichimura, Mikako Shimoda, Ayaka Nakashima, Yuka Marukawa-Hashimoto, Yusuke Kawano, Kengo Suzuki, Kenichi Yoshitomi, Masahiro Kawahara, et al. Ergothioneine Prevents Neuronal Cell Death Caused by the Neurotoxin 6-Hydroxydopamine. Cells. 2024. 13. 3
市村涼奈, 塩田沙智恵, 榊原緒妃菜, 門田佳人, 川上隆茂, 鈴木真也, 下田実可子, 川原正博, 田中健一郎. メタロチオネイン欠損マウスを用いた呼吸器疾患モデルの解析と疾患治療への応用. Biomedical Research on Trace Elements. 2023. 34. S1. 73-73

MISC (66)：

田中健一郎, 上原唯, 舩山梨音子, 下田実可子, 杉本明夫, 一谷正己, 門田佳人, 川上隆茂, 鈴木真也, 川原正博. Functional analysis of metallothionein (MT) against lung injury caused by air pollutants and establishment of preventive methods. 衛生薬学・環境トキシコロジー講演要旨集. 2024. 2024
川原正博, 田中健一郎, 根岸みどり. Neurotoxicity of perfluorooctanoic acid (PFOA) on immortalized hypothalamic neurons (GT1-7 cells). 日本薬学会年会要旨集(Web). 2024. 144th
上原唯, 穂坂彩乃, 下田実可子, 中島綾香, 鈴木健吾, 安田光佑, 川原正博, 川原正博, 田中健一郎, 田中健一郎. Wild watermelon juice prevents acute lung injury caused by air pollutantsthrough its antioxidant properties. 日本薬学会年会要旨集(Web). 2024. 144th
舩山梨音子, 虎谷愛絵理, 下田実可子, 川原正博, 川原正博, 浜進, 浜進, 田中健一郎, 田中健一郎. Establishment of a method to prevent lung injury caused by air pollutants using oleanolic acid, a component of grape peel. 日本薬学会年会要旨集(Web). 2024. 144th
湯澤彩帆, 市村涼奈, 下田実可子, 中島綾香, 橋本祐佳, 河野祐介, 鈴木健吾, 吉冨健一, 川原正博, 川原正博, et al. Functional analysis of ergothioneine, a rare natural amino acid, against 6-OHDA-dependent neuronal cell death. 日本薬学会年会要旨集(Web). 2024. 144th

Patents (1)：

Books (9)：

Link between metal homeostasis and neurodegenerative diseases: crosstalk of metals and amyloidogenic proteins at the synapse
Springer 2017
Neuroprotective Effects of Carnosine: Possible Treatment for Neurodegenerative Disease
Nova Science Publishers 2016
Link between aluminum neurotoxicity and neurodegenerative disorders with a focus on beta-amyloid
Nova publication 2016
Disruption of metal homeostasis and the pathogenesis of prion diseases
InTech 2016
Linking薬学分析化学-シナプス構築の理論と演習
京都廣川書店 2015

Lectures and oral presentations (14)：

神経疾患発症における微量元素の役割
(第34回日本微量元素学会学術集会 2023)
培養細胞を用いて精油の効能やメカニズムを探索する
(第25回日本アロマセラピー学会学術総会シンポジウム 2022)
神経疾患における微量元素の役割~亜鉛を中心に~
(第65回神経内科懇話会 2022)
Screening and Structure Determination of Protective Substances Against Senile Dementia: From Analytical Chemistry to Neurochemistry,
(31st International Symposium on Pharamaceutical and Biomedical Analysis (PBA2021) 2021)
神経疾患発症における金属の影響:金属-金属および金属-タンパク質相互作用による神経細胞死
(第74回日本酸化ストレス学会・第21回日本NO学会合同学術集会)

Professional career (1)：

Work history (5)：

2015/04/01 - 現在 Musashino University of Pharmaceutical Sciences, Graduate School
2014/04/01 - 現在 Musashino University of Pharmaceutical Sciences, Graduate School
2012/04/01 - 現在 Musashino University Faculty of Pharmacy, Department of Pharmaceutical Sciences
2003/04 - 2012/03 Professor
1990/04 - 2003/03 Researcher

Committee career (4)：

Awards (7)：

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Association Membership(s) (6)：

日本味と匂い学会 , Biophysical Society , Society for Neuropscience , 日本薬学会 , 日本微量元素学会 , 日本神経化学会

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