Uhara Hisashi

ウハラヒサシ | Uhara Hisashi

Affiliation and department：
Job title： Professor &Chairman
Homepage URL (2)： http://web.sapmed.ac.jp/derm/ , http://www.shinshu-u.ac.jp/faculty/medicine/chair/i-hifu/index.html

Research field (1)： Dermatology

Research keywords (8)： Ultrasonography , dermoscopy , immune related adverse events , liquid biopsy , cancer immunology , genetics , melanoma , skin cancer

Research theme for competitive and other funds (10)：

2022 - 2025 メラノーマにおける複数の変異遺伝子を候補とした個別化リキッドバイオプシー法の確立
2019 - 2022 Characterization of the intratumoral ecosystem in melanoma by single-cell RNA-seq analysis
2019 - 2019 美白化合物のメラノーマ細胞障害作用を利用した新規メラノーマ治療薬の開発
2016 - 2018 メラノーマ患者の血液循環腫瘍由来RNAを用いた病勢モニタリング法の確立
2014 - 2016 血液循環腫瘍DNAを用いたメラノーマ患者の遺伝子解析

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Papers (276)：

Kenji Yokota, Tatsuya Takenouchi, Yasuhiro Fujisawa, Satoshi Fukushima, Hiroshi Uchi, Takashi Inozume, Yoshio Kiyohara, Hisashi Uhara, Kazuhiko Nakagawa, Hiroshi Furukawa, et al. Long-term follow-up results from KEYNOTE-041: Phase 1b study of pembrolizumab in Japanese patients with advanced melanoma. The Journal of dermatology. 2024
Terufumi Kubo, Kenta Sasaki, Sayuri Sato, Tomoyuki Minowa, Tokimasa Hida, Kenji Murata, Takayuki Kanaseki, Tomohide Tsukahara, Yoshihiko Hirohashi, Hisashi Uhara, et al. Distinct induction pathways of heat shock protein 27 in human keratinocytes: Heat stimulation or capsaicin through phosphorylation of heat shock factor 1 at serine 326 and/or suppression of ΔNp63. Biochemical and biophysical research communications. 2024. 708. 149817-149817
Kazuki Furudate, Junji Kato, Kohei Horimoto, Sayuri Sato, Tokimasa Hida, Masahide Sawada, Tomoyuki Minowa, Hisashi Uhara. Melanoma incidence on the non-weight-bearing areas of the sole. The Journal of dermatology. 2024
Nayuha Shogase, Tomoyuki Minowa, Junji Kato, Kohei Horimoto, Sayuri Sato, Tokimasa Hida, Yoshihiko Hirohashi, Toshihiko Torigoe, Hisashi Uhara. Characterization of CD4 T-cell phenotype in human leukocyte antigen class II-positive acral melanoma. The Journal of dermatology. 2023
Takahiko Abe, Tokimasa Hida, Takafumi Kamiya, Kanako Ebata, Shintaro Sugita, Rie Kaneko, Mio Tanaka, Haruhiko Maruyama, Akira Suzuki, Hisashi Uhara. Four cases of gnathostomiasis due to the ingestion of raw Salangichthys microdon. The Journal of Dermatology. 2023

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MISC (71)：

箕輪智幸, 箕輪智幸, 村田憲治, 廣橋良彦, 宇原久, 鳥越俊彦. Comprehensive single-cell immune profiling of tumor-infiltrating lymphocytes in acral melanoma. 日本病理学会会誌. 2023. 112. 1
佐藤さゆり, 肥田時征, 井戸川雅史, 黄倉真恵, 宇原久. MYO5A-NTRK3融合遺伝子を検出したatypical Spitz tumor. 日本皮膚科学会雑誌. 2022. 132. 5. 1363-1363
肥田時征, 井戸川雅史, 堀本浩平, 加藤潤史, 佐藤さゆり, 藤岡茉生, 丹下正一朗, 時野隆至, 宇原久. カスタムパネルシーケンスを用いた日本人メラノーマのドライバー遺伝子の検出. 日本皮膚科学会雑誌. 2021. 131. 5. 1363-1363
箕輪智幸, 肥田時征, 堀本浩平, 加藤潤史, 神谷崇文, 杉田真太朗, 井戸川雅史, 宇原久. 病理組織学的に顕著なロゼット様構造を呈したALK陽性atypical Spitz tumor. 日本皮膚科学会雑誌. 2021. 131. 5. 1417-1417
Yasuhiro Nakamura, Kenjiro Namikawa, Koji Yoshino, Shusuke Yoshikawa, Hiroshi Uchi, Katsunobu Goto, Yoshiyuki Nakamura, Satoshi Fukushima, Yukiko Kiniwa, Tatsuya Takenouchi, et al. Real-world efficacy of anti-PD-1 antibodies in advanced acral melanoma patients: A retrospective, multicenter study (JAMP study). JOURNAL OF CLINICAL ONCOLOGY. 2019. 37. 15

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Books (1)：

WHO Classification of Skin Tumours, 4th edition 2018
World Health Organization 2018

Education (1)：

- 1986 Hokkaido University Faculty of Medicine

Professional career (1)：

Doctor of Medicine

Work history (3)：

1990/02 - 2017/01 Shinshu University School of Medicine
1990/02 - 1991/01 諏訪赤十字病院皮膚科
1986/06 - 1988/08 Resident in Dermatology, Shinshu University School of Medicine

Committee career (2)：

日本皮膚悪性腫瘍学会評議員、予後統計調査委員会委員
日本皮膚科学会代議員、ガイドライン作成委員会委員

Awards (3)：

2010 - Best Doctors in Japan (2010-)
2008 - 第72回日本皮膚科学会東部支部学術大会学会賞(Best Clinical Award)
2007 - Certificate of Recognition for Outstanding Posters in the Category Invasive&non invasive techniques - Diagnostic tools

Association Membership(s) (7)：

The Japanese Society for Plgment Cell Research , 日本皮膚悪性腫瘍学会 , ESMO , ASCO , THE JAPANESE DERMATOLOGICAL ASSOCIATION , 日本癌治療学会 , 日本癌学会

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