Rchr
J-GLOBAL ID：200901083765584044
Update date: Sep. 10, 2024
Hori Toshiyuki
ホリ トシユキ | Hori Toshiyuki
Affiliation and department：
Job title：
Professor
Other affiliations (2)：
Research field (6)：
Allergies and connective tissue disease
, Immunology
, Hematology and oncology
, Experimental pathology
, Pathobiochemistry
, Molecular biology
Research keywords (1)：
Internal Medicine, Hematology, Immunology, Pathological Medical Chemistry, Warts/Lats, Hippo pathway, Contact inhibition, guanylyl cyclase, dendritic cell, immune regulation
Research theme for competitive and other funds (19)：
- 2013 - 2016 The elucidation of the mechanism of novel insulin signal via TRIM/RBCC E3 ligase
- 2011 - 2013 Search for RASSF-interacting molecules using C. elegans
- 2008 - 2010 Molecular pathogenesis of abnormal kpm (Lats2) expression in leukemia
- 2005 - 2009 Development of effective hematopoietic stem cell transplantation/cellular immunotherapy for adult T-cell leukemia
- 2005 - 2006 Involvement of guanylyl cyclase signals of dendritic cells in allergic state
- 2002 - 2003 Immunotherapy of hematological melignancies based on activation of innate immunity and costimulation through OX40/OX40L
- 2002 - 2002 Basic Research for AIDS control
- 2001 - 2002 Characterization of OX40+ T cells detected in patients with GVHD after hematopoietic stem cell transplantation
- 2000 - 2001 Development of novel therapies of hematologic malignancies based on the functional modulation of the OX40/gp34 system
- 1998 - 1999 Analysis of signal transduction of OX40/gp34 and its role in pathogenesis of hematologic diseases
- 1997 - 1998 Immunohematologic studies on the SDF-1/CXCR-4 system with monoclonal antibod.
- 1997 - 1997 ATL細胞に発現するT細胞活性化抗原OX40の病態生理学的意義
- 1995 - 1997 Molecular analysis of redox regulation in infectious disease and immune disease
- 1996 - 1996 T細胞の癌化に伴って発現誘導される細胞膜蛋白の構造と機能
- 1996 - 1996 ROLR OF OX40 IN IN VIVO CELL GROWTH AND ORGAN INFILTRATION OF ATL CELLS
- 1995 - 1995 T細胞腫瘍のin vivo増殖に関与する新しい細胞膜分子の同定
- 1994 - 1995 Studies on the mechanism of cell growth of ATL cells
- 1993 - 1993 Scid miceを用いたB細胞リンパ腫の発症機構の解析と治療法の開発
- 1991 - 1992 Studies on activation mechanism in the viral diseases
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Papers (121)：
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Toshiyuki Hori. Minimal Requirements for Cancer Initiation: A Comparative Consideration of Three Prototypes of Human Leukemia. Cancers. 2024. 16. 17. 3109-3109
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Momtazkari Sarah, Dev Choudhury Anahita, Wei Ern Yong Zachary, Dong Le Thanh, Nguyen Canh Hiep, Harada Kenichi, Toshiyuki Hori, Osato Motomi, Takahashi Chiaki, Cai Ping Koh, et al. Differential requirement for IL-2 and IL-23 in the differentiation and effector functions of Th17/ILC3-like cells in a human T cell line. Journal of Leukocyte Biology. 2024
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Suguru Sugimoto, Takero Shindo, Yuhei Iga, Mari Morita, Kimiko Yurugi, Kenta Masuda, Toshiyuki Hori, Masakatsu Hishizawa, Kohei Yamashita, Hironori Haga, et al. Small B-cell neoplasm responding to ibrutinib after 17 years of cold agglutinin disease symptom. 2021. 62. 12. 1678-1683
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Toshiyuki Hori, Kenta Moriyama. BCR-ABL and Src Family Kinases Induce YAP Tyrosine Phosphorylation Resulting in Survivin and Cyclin D1 Expression in Chronic Myeloid Leukemia Cells. Blood. 2019. 134. Supplement_1. 5366-5366
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Kenta Moriyama, Toshiyuki Hori. BCR-ABL induces tyrosine phosphorylation of YAP leading to expression of Survivin and Cyclin D1 in chronic myeloid leukemia cells. Int. J. Hematol. 2019
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MISC (19)：
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山内 達樹, 一戸 辰夫, 丸山 亙, 山本 和代, 石上 隆宏, 篠原 正信, 阪本 貴士, 藤田 晴之, 小林 正行, 錦織 桃子, et al. 緩和な前処置を用いた同種造血幹細胞移植後の造血器腫瘍再発例の予後に関する検討. 臨床血液. 2008. 49. 9. 1102-1102
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丸山 亙, 一戸 辰夫, 山本 和代, 石上 隆宏, 内山 達樹, 篠原 正信, 阪本 貴士, 藤田 晴之, 菱澤 方勝, 錦織 桃子, et al. 単一施設における複数回同種移植に関する検討. 臨床血液. 2008. 49. 9. 1104-1104
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篠原 正信, 諫田 淳也, 一戸 辰夫, 丸山 亙, 山本 和代, 石上 隆宏, 内山 達樹, 阪本 貴士, 藤田 晴之, 小林 正行, et al. 非血縁者間骨髄移植後の非感染性肺合併症 緩和な前処置と従来型前処置の比較. 臨床血液. 2008. 49. 9. 1219-1219
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河原 真大, 蝶名林 和久, 内山 卓, 岡 勉, スドール・マリウス, 堀 利行. Hippo経路とDNA傷害シグナルの関係 Kpm/Lats2は白血病細胞の抗がん剤感受性に影響する(Relationship between the Hippo pathway and DNA damage signals: Kpm/Lats2 affects chemo-sensitivity of leukemic cells). 日本癌学会総会記事. 2008. 67回. 136-136
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山本 和代, 近藤 忠一, 菱澤 方勝, 錦織 桃子, 山下 浩平, 一戸 辰夫, 川端 浩, 高折 晃史, 門脇 則光, 堀 利行, et al. 臍帯血移植後にdonor cell leukemiaを発症した悪性リンパ腫の1例. 臨床血液. 2008. 49. 9. 1015-1015
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Books (9)：
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わかりやすい内科学
文光堂 2008
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今日の治療指針
医学書院 2006
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別冊・医学のあゆみ「CD抗原と疾患」
医歯薬出版 2001
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Annual Review血液1999
中外医学社 1999
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「遺伝子治療ーその臨床展開と将来」
真興交易医書出版部 1997
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Lectures and oral presentations (35)：
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慢性骨髄性白血病(CML)細胞におけるSurvivin発現の分子機構
(第41回日本分子生物学会年会 2018)
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Hippo経路因子LATS2のユビキチン化制御機構の解明
(第41回日本分子生物学会年会 2018)
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ALCLにおけるNPM-ALKからSurvivin発現にいたるシグナル伝達経路の解析
(第80回日本血液学会学術集会 2018)
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FLT3-ITD陽性AML細胞の形質転換におけるHCKとSurvivinの役割
(第80回日本血液学会学術集会 2018)
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Molecular mechanism of Survivin expression in anaplastic large cell lymphoma
(第77回日本癌学会学術総会 2018)
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Education (2)：
- - 1988 Kyoto University "Graduate School, Division of Medicine" Doctoral course
- - 1980 Kyoto University Faculty of Medicine Department of Medicine
Professional career (1)：
- Ph.D. in Medical Science (Kyoto University)
Work history (7)：
Committee career (4)：
- 日本血液学会近畿血液地方会(評議員)
- 日本血液学会(代議員、血液専門医)
- 日本内科学会近畿地方会(評議員)
- 日本内科学会(認定内科医、総合内科専門医)
Association Membership(s) (5)：
Japanese Society for Immunology
, The Japanese Society of Internal Medicine
, The Japanese Society of Hematology
, Japanese Cancer Association
, Molecular Biology Society of Japan
