Rchr
J-GLOBAL ID：200901083789547484
Update date: Oct. 08, 2024
Kitagawa Masatoshi
キタガワ マサトシ | Kitagawa Masatoshi
Affiliation and department：
Job title：
Professor
Homepage URL (1)：
http://www.hama-med.ac.jp/uni_education_igakubu_igaku_seika1.html
Research field (6)：
Molecular biology
, Tumor biology
, Functional biochemistry
, Pathobiochemistry
, Cell biology
, Pharmaceuticals - chemistry and drug development
Research keywords (11)：
細胞運命制御
, がん抑制遺伝子産物
, ubiquitin system
, long non-coding RNA
, 分子標的創薬
, X染色体不活性化
, 上皮間葉転換
, がん転移
, Cell cycle regulation
, DNA障害応答
, エピゲノム制御
Research theme for competitive and other funds (68)：
- 2024 - 2028 ICI感受性に関与するヌクレオチド除去修復機構の解明とその医学応用
- 2022 - 2026 X染色体活性化状態に注目した女性口腔がんの新たな予後診断法の確立
- 2022 - 2026 Cancer cell fate control by long-chain ncRNAs that regulate the gene specificity of epigenome factors
- 2021 - 2023 Molecular mechanisms of development of malignant female cancers associated with X-chromosome reactivation
- 2020 - 2023 複製ストレス応答における癌抑制因子の新機能と染色体不安定化の抑制機構の解明
- 2020 - 2023 Analysis of aberrant Akt/mTOR signature for the precision medicine in lung carcinoma
- 2019 - 2022 Elucidation of homologous recombination depending on X-chromosome status which associates onset and progression of female tumors
- 2019 - 2022 LncRNA connecting H3K27 demethylation with signal transduction cancer controls cell fate regulation.
- 2017 - 2022 Dysregulation of AKT network and its application for precision medicine in lung cancer
- 2016 - 2019 A novel regulatory mechanism of TGF-beta pathway via long non-coding RNA
- 2016 - 2018 Regulatory mechanism of homologous recombination in a Sex-chromosome-dependent manner
- 2015 - 2018 Mechanisms of liver metastasis via alteration of miRNA expression in gastrointinal malignancies
- 2014 - 2018 Involvement of Akt/mTOR in lung cancer and design of novel therapy targeting them
- 2013 - 2017 Molecular mechanisms of crosstalk between DNA-damage response and signal transduction
- 2014 - 2016 Long non-coding RNA associated with cancer stemness
- 2013 - 2015 腎臓および肺の線維化を左右するユビキチン制御の解明
- 2012 - 2015 Novel therapeutic targets of gastrointestinal stromal tumors
- 2012 - 2014 Exploration of novel molecular targets for anti-cancer drug in long non-coding RNAs
- 2011 - 2013 Aberrant activations of cellular kinases and exploration of novel targeted therapy in human solid cancers
- 2010 - 2012 Novel functions and regulatory mechanisms of tumor suppressor Mig-6
- 2009 - 2011 The analysis of the correlation between the increase of Pirh2 expression and cancer progress
- 2007 - 2011 Cell cycle regulation via ubiquitin system
- 2008 - 2010 Enhancement of vascular vessels senescence caused by a fibrinolytic inhibitor, PAI-1.
- 2007 - 2008 Regulation of DNA replication and repair by ubiquitin or ubiquitin-like modification in cancer cells
- 2007 - 2008 Evaluation of GPR48 as a novel molecular target which is involved in the tumor progression
- 2007 - 2008 Functional analysis of tumor metastasis promoting gene induced by p27-downregulation
- 2007 - 2008 p53制御分子Pirh2の新たなユビキチン化標的分子とがん化との関連
- 2005 - 2007 Establishment of immortalized culture-cells derived from cone and rod photoreceptors and construction of in vitro model system of retinal diseases
- 2005 - 2006 個体レベルでの細胞周期のリアルタイムイメージングの試み
- 2005 - 2006 Progression of kidney fibrosis and ubiquitin-proteasome degradation of inhibitory factors for Smad-TGF-p signaling
- 2005 - 2006 Ubiquitination of overexpressed protein and enclosure by inducible ER membrane
- 2005 - 2006 Degradation of the CDK inhibitor p27^<Kip1> by a novel ubiquitin ligase.
- 2005 - 2006 Analysis of p27 responsive gene as a novel molecular therapeutic target
- 2005 - 2006 タンパク質の誤局在、過剰産生ストレスに対する膜構造変化を伴う細胞応答
- 2005 - 2005 p53制御分子Pirh2の新たなユビキチン化標的分子とがん化との関連
- 2004 - 2005 Analysis and clinical application of ubiquitin system as a new target molecule in non-small cell lung cancer.
- 2004 - 2005 Roles of P27/Skp2 pathway and identification of target genes on tumor malignancy of colon cancer
- 2004 - 2005 Regulation of tumor suppressor RB pathway via ubiquitin system.
- 2004 - 2005 RBファミリータンパク質のリン酸化と分解を介した細胞周期制御機構
- 2004 - 2004 p27^<Kip1>の発現量低下を伴う予後不良の癌の分子標的の同定
- 2003 - 2004 The role of ubiquitin-proteasome degradation pathway in TGF-β-Smad signaling in kidney diseases
- 2003 - 2004 Identification of genes associated with poor prognosis
- 2000 - 2004 Investigation into the molecular mechanisms underlying proteolysis of CDK inhibitor p27
- 2003 - 2003 p27Kip1の発現量低下を伴う予後不良の癌における悪性形質の形成機構
- 2002 - 2003 Roles of p27^<Kip1> on metastasis of human gastric cancers
- 2002 - 2003 Accelerated degradation of tumor suppressor gene products in human cancers
- 2002 - 2003 RBタンパク質のリン酸化と分解を介した標的遺伝子選択的制御機構
- 2002 - 2002 p27^<kip1>の発現量低下による予後不良の癌形質の形成メカニズムの研究
- 2001 - 2001 癌関連細胞周期調節遺伝子のソマティックノックアウト細胞の作成とその解析
- 2001 - 2001 p27^<kip1>のコンデショナルノックアウトによるヒト腫瘍の悪性化の解析
- 2001 - 2001 RBタンパク質の部位特異的リン酸化を介した標的遺伝子選択的制御機構
- 2000 - 2001 Functional analysis of ubiquitin ligase by knock-out mise
- 2000 - 2001 Application of ubiquitin ligase against tumor suppressor gene products for cancer therapy
- 2000 - 2000 分解耐性型p27kip1の分子デザインと癌治療への応用
- 1999 - 2000 Identification of the factors mediating ubiquitination of inclusion body in neurodegenerative diseases
- 1999 - 2000 細胞周期調節分子の分解制御に関する研究-マウスSCF複合体の遺伝子クローニングと解析-
- 1999 - 1999 細胞周期制御因子の分解機構の解明とノックアウトマウスを用いた発がん研究
- 1998 - 1999 Regulation of degradation of p27Kip1, one of CDK inhibitory protein, for cancer therapy
- 1998 - 1999 Identification and functional analysis of S phase promoting complex in mammalian cell growth
- 1998 - 1998 細胞周期調節分子の分解制御に関する研究 - Yeast three-hybrid法の確立と応用 -
- 1998 - 1998 サイクリン依存性キナーゼ阻害分子の分解機構の解明
- 1997 - 1998 Analysis of sinnalling pathway of apoptosis degradation using PKCδ gene-targeting mice
- がん抑制遺伝子産物の機能と制御機構の研究
- 蛋白質の分解機構の研究
- 細胞周期の制御機構の研究
- Regulation of tumor Suppressor gene products
- Proteolysis
- Cell-cycle regulation
Show all
Papers (155)：
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Takahito Suzuki, Satoshi Sakai, Kosuke Ota, Mika Yoshida, Chiharu Uchida, Hiroyuki Niida, Takafumi Suda, Masatoshi Kitagawa, Tatsuya Ohhata. Expression of Tumor Suppressor FHIT Is Regulated by the LINC00173-SNAIL Axis in Human Lung Adenocarcinoma. International journal of molecular sciences. 2023. 24. 23
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Maya Suzuki, Satoshi Sakai, Kosuke Ota, Yuki Bando, Chiharu Uchida, Hiroyuki Niida, Masatoshi Kitagawa, Tatsuya Ohhata. CCIVR2 facilitates comprehensive identification of both overlapping and non-overlapping antisense transcripts within specified regions. Scientific reports. 2023. 13. 1. 14807-14807
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Chiharu Uchida, Hiroyuki Niida, Satoshi Sakai, Kenta Iijima, Kyoko Kitagawa, Tatsuya Ohhata, Bunsyo Shiotani, Masatoshi Kitagawa. p130RB2 positively contributes to ATR activation in response to replication stress via the RPA32-ETAA1 axis. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2023. 1870. 6. 119484-119484
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Kosuke Ota, Satoshi Sakai, Tatsuya Ohhata, Takahito Suzuki, Chiharu Uchida, Hiroyuki Niida, Masatoshi Kitagawa. APOBEC3B expression is promoted by lincNMR collaborating with TGF-β-Smad pathway. Carcinogenesis. 2022. 44. 1. 1-14
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Tatsuya Ohhata, Maya Suzuki, Satoshi Sakai, Kosuke Ota, Hazuki Yokota, Chiharu Uchida, Hiroyuki Niida, Masatoshi Kitagawa. CCIVR facilitates comprehensive identification of cis-natural antisense transcripts with their structural characteristics and expression profiles. Scientific reports. 2022. 12. 1. 15525-15525
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MISC (26)：
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Long non-coding RNA and cellular senescence. Cell technology. 2011. 30. 7. 729-733
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丹伊田浩行, 勝野裕子, 仙石実鈴, 湯川愛, 島田緑, 井倉正枝, 井倉毅, 河野一輝, 島弘季, 鈴木秀和, et al. 「GI 期DNA 修復においてダメージ部位へのTip60 依存的ribonucleotide reductase 集積 は必須である」. 日本放射線影響学会第53 回大会 2010 年10 月. 2010
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Cell cycle control via ubiquitin-proteasome system. The Cell. 2008. 40. 1. 42-46
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北川 雅敏, 平松 良浩, 今野 弘之. サイクリンD1の新たな発現制御機構(Novel regulatory mechanisms of Cyclin D1 expression). 日本癌学会総会記事. 2007. 66回. 453-453
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土橋 洋, 北川 雅敏, 後藤 明輝, 深山 正久, 鈴木 潮人, 大井 章史. 培養細胞とヒト腫瘍におけるCyclin/Cdk過剰発現とアポトーシスとの関連. 日本癌学会総会記事. 2003. 62回. 242-242
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Patents (8)：
Books (7)：
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細胞周期集中マスター
羊土 社 2006
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ユビキチンープロテアソームシステム
新女性医学大系「婦人科腫瘍の分子細胞生物学」 2001
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ユビキチンープロテアソームによるシグナル伝達分子の量的制御機構
「シグナル伝達がわかる」羊士社 2000
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タンパク質分解システムと細胞周期の制御機構
わかる細胞周期と癌 2000
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RB蛋白質
「細胞周期研究法」羊土社 1995
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Education (3)：
- - 1987 The University of Tokyo
- - 1984 金沢大学大学院 薬学研究科修士課程
- - 1982 Tokyo University of Science Faculty of Pharmaceutical Sciences Department of Pharmacy
Professional career (1)：
- Ph.D. (The University of Tokyo)
Work history (4)：
- 2020/04 - 現在 Hamamatsu University School of Medicine
- 2000/10 - 現在 Hamamatsu University School of Medicine Department of Molecular Biology Professor
- 1997 - 2000 Kyushu University Medical Institute of Bioregulation
- 1987 - 1997 萬有製薬(株)つくは研究所 副主任研究員
Committee career (1)：
Association Membership(s) (4)：
JAPAN SOCIETY FOR CELL BIOLOGY
, 日本生化学会
, 日本癌学会
, 日本分子生物学会
