Rchr
J-GLOBAL ID：200901084336442505   Update date: Nov. 19, 2024

Uchihashi Takayuki

Uchihashi Takayuki
Affiliation and department：
Nagoya University Graduate School of Science Division of Material Science Biophysics

About Nagoya University Graduate School of Science Division of Material Science Biophysics


Job title： Professor
Research field  (1)： Biophysics
Research keywords  (5)： Single-molecule measurement ,  Surface Science ,  Biophysics ,  Scanning Probe Microscopy ,  High-speed atomic force microscopy
Research theme for competitive and other funds  (41)：
  • 2021 - 2024 単一ゲル微粒子の強靭化に基づくミクロ空間移動科学の構築
  • 2021 - 2024 High-Speed-AFM Analysis of Structural and Mechanical Properties of Single Protein under Mechanical Stimulation
  • 2021 - 2023 Elucidation of working mechanisms of a molecular-engine complex responsible for protein membrane permeation by imaging of the conformational dynamics
  • 2020 - 2023 Study for the mechanism of functional expression and dysfunction of membrane proteins through direct observations of single molecular fluctuation
  • 2019 - 2023 再構成アプローチで解明するダイナミンの膜切断機構とその破綻に起因する疾患発症機序
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Papers (295)：
  • Maho Yagi-Utsumi, Yui Kanaoka, Shogo Miyajima, Satoru G. Itoh, Katsuhiko Yanagisawa, Hisashi Okumura, Takayuki Uchihashi, Koichi Kato. Single-Molecule Kinetic Observation of Antibody Interactions with Growing Amyloid β Fibrils. Journal of the american chemical society. 2024
  • Yuma Sasaki, Yuichiro Nishizawa, Natsuki Watanabe, Takayuki Uchihashi, Daisuke Suzuki. Elastomer Particle Monolayers Formed by the Compression of Poly(methyl acrylate) Microparticles at an Air/Water Interface. Macromolecular Rapid Communications. 2024
  • Tatsuki Tanaka, Shoko Hososhima, Yo Yamashita, Teppei Sugimoto, Toshiki Nakamura, Shunta Shigemura, Wataru Iida, Fumiya K Sano, Kazumasa Oda, Takayuki Uchihashi, et al. The high-light-sensitivity mechanism and optogenetic properties of the bacteriorhodopsin-like channelrhodopsin GtCCR4. Molecular cell. 2024. 84. 18. 3530-3544
  • Norihiro Takekawa, Tatsuro Nishikino, Jun-Ichi Kishikawa, Mika Hirose, Miki Kinoshita, Seiji Kojima, Tohru Minamino, Takayuki Uchihashi, Takayuki Kato, Katsumi Imada, et al. Structural analysis of S-ring composed of FliFG fusion proteins in marine Vibrio polar flagellar motor. mBio. 2024. e0126124
  • Hiroki Oda, Shigetaka Nishiguchi, Chihong Song, Kazuyoshi Murata, Takayuki Uchihashi, Yuki Suzuki. Nanoscale visualization ofDrosophilaE-cadherin ectodomain fragments and their interactions using DNA origami nanoblocks. 2024
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MISC (80)：
  • Shigetaka Nishiguchi, Rinshi S. Kasai, Takayuki Uchihashi. Data for: Antiparallel dimer structure of CELSR cadherin in solution revealed by high-speed atomic force microscopy. Mendeley Data. 2023
  • 伊達弘貴, PHAM Thuc Toan, LEE Hyeonho, 内橋貴之, 上久保裕生, SONG Chihong, 村田和義, 上野隆史. Structure analysis of pH-responsive piston dynamics of R-body. 日本化学会春季年会講演予稿集(Web). 2023. 103rd
  • 竹川宜宏, 錦野達郎, BURTON-SMITH Ray, 池田充, 多治見祐希, 村田和義, 小嶋誠司, 内橋貴之, 今田勝巳, 本間道夫. Structure and function of stomatin-like protein FliL to assist flagellar motor stator PomAB in marine Vibrio. 日本生体エネルギー研究会討論会講演要旨集. 2023. 49th
  • 鈴木綾, 上野博史, 黒崎涼, 内橋貴之, 野地博行. 病原性大腸菌EPECが有するIII型分泌装置のATPase複合体の機能解析. 日本蛋白質科学会年会プログラム・要旨集. 2021. 21st
  • 長池航, 板家成良, 春山隆充, 塚崎智也, 内橋貴之, 内橋貴之. Observation of substrate binding Sec translocon and structural change of SecA with HS-AFM. 日本生体エネルギー研究会討論会講演要旨集. 2020. 46th
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Patents (17)：
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Books (19)：
  • パリティ 2018年1月号
    丸善出版 2018
  • Compendium of Surface and Interface Analysis (The Surface Science Society of Japan, Eds)
    Springer 2018 ISBN:9789811061554
  • 光と生命の事典(真嶋哲郎, 七田芳則, 飯野盛利, 藤堂剛 編)
    朝倉書店 2016 ISBN:9784254171617
  • Noncontact Atomic Force Microscopy Vol.3 (Seizo Morita, Franz J. Giessibl, Ernst Meyer, Roland Wiesendanger, Eds)
    Springer 2015 ISBN:9783319155876
  • Atomic Force Microscopy in Nanobiology (Kunio Takeyasu Ed.)
    Pan Stanford Publishing 2014 ISBN:9789814411592
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Lectures and oral presentations  (47)：
  • Image Processing and Quantitative Analysis of High-Speed-AFM Data for Studying Single-Molecule Dynamics
    (第56回日本生物物理学会年会, Sympojium on "Multiple Approaches for Analyses of Protein Complexes -Methods and Applications" 2018)
  • 原子間力顕微鏡でリアルタイム可視化する生体/人工超分子の重合ダイナミクス
    (日本物理学会 2018年秋季大会 領域9, 5合同シンポジウム「時間分解プローブを駆使した表面・界面科学及び結晶成長の進展と展望 」 2018)
  • High-speed atomic force microscopy for direct visualization of biological macromolecules at work
    (The 79th Okazaki Conference "Synthetic, Biological, and Hybrid Molecular Engines" 2018)
  • 高速AFMの開発とタンパク質の動態計測
    (第58回生物物理若手の会 2018)
  • High-Speed Atomic Force Microscopy for Visualization and Manipulation of Biological and Artificial Molecules
    (SPMonSPM 2018 2018)
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Works (4)：
  • 高速AFMによる機能性材料の動的解析
    2007 -
  • Dynamic Analysis of Functional Materials using HIgh-speed AFM
    2007 -
  • 高速AFM法による膜タンパク質のダイナミクス計測
    2004 -
  • Dynamics of membrane proteins by high-speed AFM
    2004 -
Education (3)：
  • - 1998 Osaka University Graduate School, Division of Engineering
  • - 1995 Hiroshima University Graduate School, Division of Natural Science
  • - 1993 Hiroshima University Faculty of Science
Professional career (1)：
  • 工学 (大阪大学)
Work history (12)：
  • 2021 - 現在 Institute for Glyco-core Research (iGCORE), Tokai National Higher Education and Research System
  • 2017/04 - 現在 Nagoya University Graduate School of Science, School of Science, Professor
  • 2017/04/01 - 現在 Nagoya University Division of Material Science(Physics), Graduate School of Science Professor
  • 2015/04/01 - 2017/03/31 Kanazawa University Bio-AFM Frontier Research Center, Institute of Science and Engineering Director
  • 2015/04/01 - 2017/03/31 Kanazawa University Institute of Science and Engineering Professor
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Committee career (4)：
  • 2015 - 現在 日本生物物理学会 理事
  • 2011 - 現在 日本生物物理学会 分野別専門委員会 委員
  • 2014 - 2015 日本生物物理学会 代議員
  • 2014 - 2015 日本生物物理学会 学会誌「生物物理」編集委員会 委員
Awards (6)：
  • 2013/04 - Ministry of Education, Culture, Sports , Science and Technology, Japan Education, Culture, Sports, Science Minister's Commendation Science and Technology Award of Science and Technology Development of High-Speed Atomic Force Microscopy
  • 2007/09 - The Japan Society of Applied Physics 29th JSAP Awards “High-Speed Atomic Force Microscopy for Studying the Dynamic Behavior of Protein Molecules at Work”, Jpn. J. Appl. Phys. Vol. 45, No. 3B, 2006, pp. 1897-1903
  • 2007 - Best Paper Award of the Japan Society of Applied Physics
  • 2005 - The KAO Foundation for Arts and Sciences, Research Grant
  • 2000/12 - Joint Reserach Center for Atom Technology JRCAT Special Awards Development of Fabrication Technique of Carbonnanotube Probe
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Association Membership(s) (9)：
THE PHYSICAL SOCIETY OF JAPAN ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  THE CHEMICAL SOCIETY OF JAPAN ,  The Japan Society of Vacuum and Surface Science ,  日本生物物理学会 ,  THE JAPAN SOCIETY OF APPLIED PHYSICS ,  Japanese Surface Science Society ,  Japanese Biophysical Society ,  Japanese Applied Physics Society
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