Hanioka Nobumitsu

ハニオカノブミツ | Hanioka Nobumitsu

Affiliation and department：
Job title： Professor

Research field (2)： Environmental effects of chemicals , Pharmaceuticals - health and biochemistry

Research keywords (4)：環境化学物質 , 遺伝子多型 , 生体異物 , 薬物代謝酵素

Research theme for competitive and other funds (11)：

2023 - 2026 Construction of individualized risk evaluation system for chemicals based on the variability of xenobiotic metabolizing enzymes
2019 - 2023 Construction of risk evaluation system for environmental chemicals based on the variability of xenobiotic response elements
2018 - 2021 Development of individualized risk evaluation method for chemicals: strategy using artificial xenobiotic-metabolizing enzymes
2014 - 2017 Development of risk evaluation method for environmental chemicals based on the exposure routes
2012 - 2015 The role of morphinone in the tolerance development to morphine

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Papers (148)：

Hanioka N, Isobe T, Saito K, Nagaoka K, Mori Y, Jinno H, Ohkawara S, Tanaka-Kagawa T. Glucuronidation of tizoxanide, an active metabolite of nitazoxanide, in liver and small intestine: Species differences in humans, monkeys, dogs, rats, and mice and responsible UDP-glucuronosyltransferase isoforms in humans. Comp Biochem Physiol C Toxicol Pharmacol. 2024. 283. 109962-109962
Hanioka N, Isobe T, Saito K, Nagaoka K, Mori Y, Jinno H, Ohkawara S, Tanaka-Kagawa T. Hepatic glucuronidation of tetrabromobisphenol A and tetrachlorobisphenol A: interspecies differences in humans and laboratory animals and responsible UDP-glucuronosyltransferase isoforms in humans. Archives of Toxicology. 2024
Isobe T, Ohkawara S, Mori Y, Jinno H, Tanaka-Kagawa T, Hanioka N. Hydrolysis of dibutyl phthalate and di(2-ethylhexyl) phthalate in human liver, small intestine, kidney, and lung: An in vitro analysis using organ subcellular fractions and recombinant carboxylesterases. Chem Biol Interact. 2023. 372. 110353-110353
Mori Y, Tanaka-Kagawa T, Tahara M, Kawakami T, Aoki A, Okamoto Y, Isobe T, Ohkawara S, Hanioka N, Azuma K, Sakai S, Jinno H. Species differences in activation of TRPA;by resin additive-related chemicals relevant to indoor air quality. J Toxicol Sci. 2023. 48. 1. 37-45
Mori Y, Aoki A, Okamoto Y, Isobe T, Ohkawara S, Hanioka N, Tanaka-Kagawa T, Jinno H. Species-specific activation of transient receptor potential ankyrin 1 by phthalic acid monoesters. Biol Pharm Bull. 2022. 45. 12. 1839-1846

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MISC (1)：

Tsuneto Yumi, Hanioka Nobumitsu, Saito Yoshiro, Sumada Tomoko, Maekawa Keiko, Saito Keita, Sawada Jun-ichi, Narimatsu Shizuo. FUNCTIONAL CHARACTERIZATION OF TWO NOVEL CYP2C19 VARIANTS (CYP2C19^*18 AND CYP2C19^*19) FOUND IN A JAPANESE POPULATION. Abstracts of Annual meeting of Japanese Society for the Study of Xenobiotics. 2006. 21. 0. 308-308

Professional career (1)：

Work history (8)：

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Association Membership(s) (3)：

日本毒性学会 , 日本薬物動態学会 , 日本薬学会

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