Research field (8)：
Neuroscience - general
, Metabolism and endocrinology
, Other
, Immunology
, Genomics
, Pharmacology
, Pathobiochemistry
, Medical biochemistry
2019 - 2022 Development of a treatment to eliminate delayed bone healing due to diabetes
2019 - 2021 Identification and analysis of a new group of diseases with a common etiology of abnormal immune response to embryonic signals
2019 - 2021 胚シグナルに対する免疫応答異常を共通の病因とする新しい疾患群の同定と解析
2018 - 2021 Analysis of the role of miR-34a in osteosarcoma stem cell models and its potential therapeutic targets
2018 - 2021 The basic research on the effect of cultured lymphatic transplantation and the barrier of scar to lymphatic regeneration.
2018 - 2021 Investigation of molecular devices for oxytocin transport into the brain
2017 - 2020 慢性炎症と線維化をきたす生体ネットワークの解明とその制御の国際研究拠点形成
2016 - 2019 Revealing mechanism of delayed bone union by glycation stress and development new drug
2016 - 2018 Innovation of novel therapeutics against diabetic nephropathy targeting ChREBP
2015 - 2018 Establishment of osteosarcoma stem cell model induced by RAGE and elucidation of its molecular mechanism
2015 - 2018 Molecular analysis aiming therapeutic application of epithelial-mesenchymal transition in rheumatoid arthritis synovium
2015 - 2017 Mechanism of postprandial hyperglycemia due to transporter gene knockout and identification of endogenous substrates
2014 - 2017 Identification of RAGE inhibitory components in foods and elucidation of its inhibitory mechanism
2013 - 2016 Analysis of the distribution and differentiation potency of adipocyte precursor cells in mesentery of Suncus murinus
2013 - 2016 To unveil mechanisms triggering pancreatic beta cell dysfunction in type 2 diabetes possibly via RAGE, glucolipotoxicity and insufficient leptin signaling.
2012 - 2015 A strategy of RAGE shedding is promising for conquering diabetic vascular complications
2011 - 2013 Identifying challenges to discover cancer stem-like cells in osteosarcoma
2007 - 2010 Genesis and physiologic significance of secretory RAGE-a new vasoprotective factor
2006 - 2007 Study on signal generation mechanism of a multi-ligand receptor,RAGE
2004 - 2006 グライコミクスによる糖尿病合併症発症の新機序の解明
2005 - 2006 Study on the mechanisms of alternative mRNA splicing that regulates the regulation of angiogenesis and diabetic complication susceptibility
2004 - 2006 内在性分泌型RAGEタンパクの病原微生物に対する防御作用
2006 - Inflammation in obesity
2004 - 2005 Study of the signaling network via mutifundtional receptor, RAGE.
2002 - 2004 遺伝子ターゲティングによる糖尿病血管合併症の原因・治療の解明
2004 - Innnate immunity
2003 - 2003 新しい機能性遺伝子同定技術の創出と成人病性血管障害関連遺伝子探索への応用
2002 - 2003 Study on the mechanism of vascular injury by novel species of advanced glycation endoproducts
2000 - 2002 発生工学的手法を用いた糖尿病性血管合併症発症機構の解明
2002 - 2002 新しい機能性遺伝子同定技術の創出と成人病性血管障害関連遺伝子探索への応用
2001 - 2002 Study on file RAGE signaling in vascular cells - a novel mechanism of the development of diabetic vascular complications
2001 - 2001 新しい機能性遺伝子同定技術の創出と成人病性血管障害関連遺伝子探索への応用
1997 - 2001 糖尿病血管合併症発症メカニズムの解明と治療法の開発
1997 - 2001 Molecular mechanism for development of diabetic vascular complications
Hiroaki Sugita, Shinichi Nakanuma, Seiichi Munesue, Tatsuya Ishikawa, Tomokazu Tokoro, Ryohei Takei, Mitsuyoshi Okazaki, Kaichiro Kato, Satoshi Takada, Isamu Makino, et al. Cilostazol improves the prognosis after hepatectomy in rats with sinusoidal obstruction syndrome. Journal of gastroenterology and hepatology. 2024
Dasen Ye, Akio Miyoshi, Tomoe Ushitani, Manabu Kadoya, Masataka Igeta, Kosuke Konishi, Takuhito Shoji, Koubun Yasuda, Shiho Kitaoka, Hideshi Yagi, et al. RAGE in circulating immune cells is fundamental for hippocampal inflammation and cognitive decline in a mouse model of latent chronic inflammation. Brain, behavior, and immunity. 2024. 116. 329-348
Tuerdiguli Abuduyimiti, Hisanori Goto, Kumi Kimura, Yu Oshima, Ryota Tanida, Kyoko Kamoshita, Nontaphat Leerach, Halimulati Abuduwaili, Hein Ko Oo, Qifang Li, et al. Diabetes accelerates steatohepatitis in mice: liver pathology and single-cell gene expression signatures. The American Journal of Pathology. 2024
Naoki Takahashi, Seiji Yokoi, Hideki Kimura, Hironobu Naiki, Taiji Matsusaka, Yasuhiko Yamamoto, Kimihiko Nakatani, Kenji Kasuno, Masayuki Iwano. Renoprotective effects of extracellular fibroblast specific protein 1 via nuclear factor erythroid 2-related factor-mediated antioxidant activity. Scientific reports. 2023. 13. 1. 22540-22540
