Tougan Takahiro

トウガンタカヒロ | Tougan Takahiro

Affiliation and department：
Other affiliations (1)：

Osaka University Research Institute for Microbial Diseases SA Associate Professor

Research field (3)： Pharmaceuticals - health and biochemistry , Molecular biology , Parasitology

Research theme for competitive and other funds (22)：

2020 - 2023 マラリア原虫を特徴づける生物学的分子基盤の解明とその応用
2019 - 2022 感染赤血球特異的なホスファチジルセリン露出誘導による免疫誘導型抗マラリア薬の創出
2020 - 2021 薬剤耐性株にも効果を示す赤血球期マラリア原虫を標的とした新規マラリア治療薬
2019 - 2020 抗マラリア活性を持つ新規リード化合物の作用機序の解明と実用化
2019 - 2020 薬剤耐性株にも効果を示す赤血球期マラリア原虫を標的とした新規マラリア治療薬

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Papers (63)：

Yusuke Hirasawa, Yusuke Kakizoe, Takahiro Tougan, Nahoko Uchiyama, Toshihiro Horii, Hiroshi Morita. Vincarostine A, a novel anti-malarial trimeric monoterpenoid indole alkaloid from Catharanthus roseus. Journal of Natural Medicines. 2024. 78. 3. 768-773
Nirianne Marie Q Palacpac, Ken J Ishii, Nobuko Arisue, Takahiro Tougan, Toshihiro Horii. Immune tolerance caused by repeated P. falciparum infection against SE36 malaria vaccine candidate antigen and the resulting limited polymorphism. Parasitology international. 2024. 99. 102845-102845
Alfarius Eko Nugroho, Tomoyuki Komuro, Takuya Kawaguchi, Yusuke Shindo, Chin Piow Wong, Yusuke Hirasawa, Toshio Kaneda, Takahiro Tougan, Toshihiro Horii, A Hamid A Hadi, et al. Ceramicines U-Z from Chisocheton ceramicus and structure-antimalarial activity relationship study. Journal of natural medicines. 2023
Alfarius Eko Nugroho, Chin Piow Wong, Yusuke Hirasawa, Toshio Kaneda, Takahiro Tougan, Toshihiro Horii, A. Hamid A. Hadi, Hiroshi Morita. Antimalarial ceramicines Q-T from Chisocheton ceramicus. Journal of Natural Medicines. 2023. 77. 3. 596-603
Alfarius Eko Nugroho, Masaki Tange, Sumi Kusakabe, Yusuke Hirasawa, Osamu Shirota, Michiyo Matsuno, Hajime Mizukami, Takahiro Tougan, Toshihiro Horii, Hiroshi Morita. Chukranoids A-I, isopimarane diterpenoids from Chukrasia velutina. Journal of natural medicines. 2022. 76. 4. 756-764

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MISC (36)：

Tohihiro Horii, Takahiro Tougan. N-terminal domain of SERA 5 is a core protein that binds various host proteins to camouflage merozoite from host immunity. 2017
Jyotheeswara Edula Reddy, Takahiro Tougan, Toshihiro Horii. Localisation control of phosphatidylserine on infected erythrocyte membrane by malaria parasite. 2017
鈴木裕義, 板垣佐和子, 井塚宗久, 岡崎智紀, 内橋欣也, 東岸任弘, 堀井俊宏. 全自動マラリア感染赤血球検出試作装置を用いた培養マラリア原虫の発育ステージに関する評価 Performance evaluation of cultured malaria parasite stage by novel automated flowcytometry-based analyzer. 2016
Edula Jyotheeswara Reddy, Takahiro Tougan, Toshihiro Horii. Analysis of inhibitory mechanism for exposure of phosphatidylserine on malaria- infected erythrocyte surface. 2016
Arisue N, Honma H, Kawai S, Tougan T, Tanabe K, Horii H. 大量ゲノムデータを用いたマラリア原虫の系統解析. 2016

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Books (9)：

綜合臨牀
永井書店 2011
Pharma Medica
2011
臨床粘膜免疫学・寄生虫による粘膜感染
株式会社シナジー 2010
次世代ワクチンの産業応用技術
株)シーエムシー出版 2010
DDS
(DDS学会誌) 2010

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Lectures and oral presentations (9)：

Application of an automated hematology analyzer XN-30 for discovery and development of antimalarial drugs in vitro
(2018)
多項目自動血球分析装置(XN-30)のげっ歯類マラリアモデルへの応用
(2018)
Detection of malaria parasite by Automated Hematology Analyzer (XN-30) and its application to antimalarial drug research
(2017)
Application of antimalarial drugs for malaria biology
(2017)
Application of antimalarial drugs for malaria biology
(2017)

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Professional career (1)：

博士(医学) (大阪大学)

Awards (1)：

2014 - 大阪大学第3回大阪大学総長奨励賞

Association Membership(s) (5)：

JAPANESE SOCIETY OF TROPICAL MEDICINE , THE JAPANESE SOCIETY FOR VACCINOLOGY , JAPANESE ASSOCIATION FOR LABORATORY ANIMAL SCIENCE , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE SOCIETY OF PARASITOLOGY

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