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J-GLOBAL ID：200901085109790749 Update date: Mar. 23, 2025

Shinada Tetsuro

シナダテツロウ | Shinada Tetsuro

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.sci.osaka-cu.ac.jp/chem/henkan/

Research field (3)： Structural/physical organic chemistry , Structural/physical organic chemistry , Bioorganic chemistry

Research keywords (3)：生物有機科学 , 天然物化学 , Synthetic Studies of Natural Products

Research theme for competitive and other funds (33)：

2022 - 2025 カメムシ幼若ホルモンの合成・受容機構とその進化過程の解明
2020 - 2024 脱水素クロスカップリングを利用した機能性配向基の開発とそのペプチド合成への応用
2020 - 2024 結核に対抗するための新規分子標的の同定
2020 - 2023 Study of photoperiodic time-measurement mechanisms by circadian clock cells in an insect
2019 - 2021 Functional analysis of terpene synthases and its application to the synthesis of unusual terpenoids

2017 - 2021 Synthetic study of chiral compounds by taking advantage of an umpolung approach

2017 - 2019 Synthetic Study of Acyclic Terpene Probes to Elucidate the Reaction Mechanism of Terpenoid Biosynthesis

2016 - 2018 Exploitation of niches and diversification of organisms by utilising invisible light: the new research field of photogeobiology

2015 - 2018 Development of new anchor molecule to fix biologically active molecules on cell surface

2014 - 2018 Molecular and neural mechanisms of photoperiodism in the bean bug, Riptortus pedestris

2014 - 2017 Development of novel synthetic reactions based on mutual cooperation of nitrogen-oxygen bonds and multiple bonds

2013 - 2017 Stereoselective synthesis of mono- and di-substituted dehydroamino acids and its application to the natural product synthesis and chemical biology.

2013 - 2016 Creation of novel terpenoids from biosynthetic study on sesquarterpene

2011 - 2016 Chemical biology using natural products

2011 - 2016 Study toward Development Ionotropic Glutamate Receptore Subytpe Selective Ligand

2011 - 2016 Structure and function of an improving factor in hippocampal impairment originated from the silkworm-parasitic fungus (Paecilomyces tenuipes) and practical use for human brain

2012 - 2015 Structure determination of juvenile hormone in cicadas-an attempt to develop insecticides specific to planthoppers and leafhoppers

2009 - 2012 Synthesis of α-Amino Squaric Acid Incorporated Peptides and Their Biological Activities

2011 - 2011 鎖状テルペン類の自在合成法の開発とその応用

2008 - 2011 Central mechanism controlling photoperiodism and diapause in stink bugs.

2008 - 2010 Development of Novel Ligands for Glutamate Receptors Using Natural Neurotoxins as the Structural Motif

2007 - 2009 Regulatory mechanisms of insect ovary-development : proteases involved in oosorption and JHSB3, a new juvenile hormone controlling oosorption in Plautia stali.

2006 - 2008 Chemistry of Sq group containing amino acid (ASQ): Incorporation of ASQ into peptides and their function

2006 - 2007 クマゼミの湿度による艀化誘導機構の研究

2004 - 2007 配座及び官能基制御に基づく高活性神経リガンドの開発

2004 - 2006 DESIGN AND SYNTHESIS OF NOVEL EXCITATORY AMINO ACIDS BASED ON THE TOTAL SYNTHESIS OF NATURAL NEE TROTOXTNS

2003 - 2004 Synthesis and its function of novel squaric acid containing amino acids.

2001 - 2002 光学活性テトロドトキシン類の全合成研究

2000 - 2001 短寿命活性種オルソ酸の構造安定化:篭状オルソ酸の合成と活性

1997 - 1998 スクアリン酸含有アミノ酸類の合成研究

1997 - 1998 天然物合成を指向した含窒素4級炭素を含む3連続不斉中心構築法の開発

1997 - 高度生体応答分子の全合成

1995 - 9,13位修飾レチナ-ル類の合成

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Papers (126)：

Tohru Abe, Miyu Katano, Ikiru Otsuka, Nozomi Wakamatsu, Saya Takahashi, Daijiro Ueda, Eigo Fukuda, Seiya Endo, Keisuke Nishikawa, Yoko Yasuno, et al. Isolation and structural determination of natural products bearing tetrahydrogenated isoprenoid side-chains at their ω-termini. Organic & Biomolecular Chemistry. 2025
Kosuke Kanno, Riko Kuriki, Yoko Yasuno, Tetsuro Shinada, Tomokazu Ito, Hisashi Hemmi. Archaeal mevalonate pathway in the uncultured bacterium Candidatus Promineifilum breve belonging to the phylum Chloroflexota. Applied and Environmental Microbiology. 2024. 90. 8
Seigo Yumura, Daisuke Kitagawa, Kei Moritsugu, Atsushi Nakayama, Tetsuro Shinada, Masaaki Sawa, Takayoshi Kinoshita. Conserved gatekeeper methionine regulates the binding and access of kinase inhibitors to ATP sites of MAP2K1, 4, and 7: Clues for developing selective inhibitors. Bioorganic & Medicinal Chemistry Letters. 2024. 129914-129914
Eigo Fukuda, Ibuki Fujiwara, Shoki Maruno, Kaiki Motomura, Seiya Endo, Arihiro Iwasaki, Tatsuya Fukuta, Atsushi Nakayama, Tetsuro Shinada. Total Synthesis of Bipenicilisorin and Assignment of the Absolute Configuration. Journal of natural products. 2024
Shunki Sakata, Jiafeng Li, Yoko Yasuno, Tetsuro Shinada, Kazuo Shin-Ya, Yohei Katsuyama, Yasuo Ohnishi. Identification of the Cirratiomycin Biosynthesis Gene Cluster in Streptomyces Cirratus: Elucidation of the Biosynthetic Pathways for 2,3-Diaminobutyric Acid and Hydroxymethylserine. Chemistry (Weinheim an der Bergstrasse, Germany). 2024. e202400271

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MISC (264)：

末宗周憲, 永田隆平, 永田隆平, 小林正弥, 品田哲郎, 西山真, 西山真, 葛山智久, 葛山智久, 佐藤裕介, et al. スクアレン合成酵素に類似した放線菌由来カルバゾールプレニル基転移酵素の結晶構造と反応機構. 日本蛋白質科学会年会プログラム・要旨集. 2021. 21st
亀谷太一, 久保田智巳, 品田哲郎, 上田大次郎, 佐藤努. トリテルペン/セスクアテルペン環化酵素の立体構造解析. イソプレノイド研究会例会講演要旨集. 2021. 31st (CD-ROM)
浅田和也, 上田大次郎, 三木邦夫, 藤橋雅宏, 品田哲郎, 佐藤努. Analysis of cyclic structure formation mechanism of class IB terpene synthase. 日本農芸化学会大会講演要旨集(Web). 2021. 2021
保野陽子, 苅田祐馬, 丸林聖司, 品田哲郎, 大石徹. ホモプシンAの全合成研究. 有機合成シンポジウム講演要旨集. 2021. 118th
岡村仁則, 保野陽子, 滝川浩郷, 品田哲郎. Stereoselective synthesis of (2S,6R)-diamino-(5R,7)-dihydroxy-heptanoic acid (DADH) and its derivatives. 日本農芸化学会大会講演要旨集(Web). 2021. 2021

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Patents (10)：

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Books (3)：

化学の要点シリーズ43 海洋天然物化学
日本化学会 2023 ISBN:9784320044845
ドラマチック有機合成化学感動の瞬間
化学同人 2023 ISBN:9784759823363
Neuroprotective Properties of the Fungus Isaria Japonica: Evidence from a Mouse Model of Aged Related Degeneration
Frontiers in Clinical Drug Research-Alzheimer Disorder; Vol. 2, Bentham e-Books series 2017 ISBN:9781681083407

Lectures and oral presentations (97)：

新規イソクマリン合成法を用いた二量体天然物bipenicilisorinの全合成
(日本薬学会第143年会 2023)
ロジウム触媒を用いる9-ベンゾイルカルバゾール類と内部アルキンの環化カップリングによるインデノン誘導体合成
(日本化学会第101回春季年会(2021) 2021)
(2S,6R)-ジアミノ-(5R,7)-ジヒドロキシヘプタン酸(DADH)及びその誘導体の立体選択的合成
(日本農芸化学会 2021年度大会 2021)
非タンパク質構成アミノ酸DADH及びその誘導体の合成
(日本化学会第101回春季年会(2021) 2021)
オケビラゴケ由来ビベンジルカンナビノイドの生合成研究
(日本農芸化学会 2021年度大会 2021)

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Education (4)：

1989 - 1992 神戸薬科大学大学院薬学研究科博士後期課程
- 1992 Kobe Pharmaceutical University
1987 - 1989 Kobe Pharmaceutical University Graduate School, Division of Pharmaceutical Sciences
1983 - 1987 Setsunan University Faculty of Pharmaceutical Science Department of Pharmaceutical Sciences

Professional career (1)：

Doctor of Pharmaceutical Science (Kobe Pharmaceutical University)

Work history (8)：

2022/04 - 現在大阪公立大学大学院理学研究科化学専攻教授
2010/10 - 2022/03 Osaka City University Graduate School of Science Molecular Materials Science Course Professor
2004/04 - 2010/09 大阪市立大学大学院理学研究科物質分子系専攻准教授
1996/04 - 2004/03 Osaka City University Graduate School of Science Molecular Materials Science Course lecturer
1994/03 - 1996/03 Suntory Ltd.

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Committee career (6)：

2011/10 - 現在香料・テルペンおよび精油化学に関する討論会幹事
2011/10 - 現在天然有機化合物討論会世話人
2011/01 - 現在日本化学会 Chemistry Letters編集委員
2023/02 - 2023/12 第15回京都国際有機化学会議委員
2016/04 - 2018/03 有機合成化学協会評議員

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Awards (3)：

2019/12 - 有機合成化学協会令和元年度カネカ生命科学賞
2019/12 - 有機合成化学協会カネカ・生命科学賞有機合成化学を基盤とするテルペン系天然物の生合成および生物機能の解明
2008 - 第6回有機合成化学協会関西支部賞

Association Membership(s) (7)：

日本農芸化学会 , アメリカ化学会 , THE CHEMICAL SOCIETY OF JAPAN , 有機合成化学協会 , 日本薬学会 , 近畿化学協会 , 応用動物昆虫学会

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