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J-GLOBAL ID：200901085500442933 Update date: Mar. 06, 2025

Nakamura Kazuhiko

ナカムラカズヒコ | Nakamura Kazuhiko

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Affiliation and department：
Other affiliations (1)：

弘前大学大学院医学研究科附属子どものこころの発達研究センターセンター長

Research field (1)： Psychiatry

Research theme for competitive and other funds (60)：

2019 - 2024 3歳児における発達障害の疫学研究および早期発見のための新たな診断ツールの開発
2021 - 2024 コホート研究による子どもの自殺関連因子と予測因子の解明
2019 - 2023 発達障害の併存・合併症問題の精神病理の解明と個別化した早期治療の探求
2020 - 2023 神経発達障害の脆弱性と予測因子に関する研究
2019 - 2022 Early detection and support of autistic spectrum disorder focusing on sensory processing characteristics

2019 - 2022 ASD

2018 - 2022 Elucidation of visual information processing function of developmental coordination disorder

2018 - 2021 Validation of the web-based screening tool for identifying developmental disabilities in a community sample.

2018 - 2021 Epidemiological study on new concept adult ADHD in Japan

2016 - 2019 Epidemiological study and Creating new diagnostic methods for Neurodevelopmental disorders in 5-year-old children

2016 - 2019 Improvement of Early Screening Accuracy in High-Functioning Autism Spectrum Disorder

2016 - 2019 A relationship between child's characteristics of developmental disorder, characteristics of sensory processing, and difficulty of daily life

2014 - 2019 Constructing a Monitor Corpus of the Spoken Language of Autism Spectrum Disorder and drawing up Diagnostic Guidelines

2014 - 2018 Constructing a Monitor Corpus of the Spoken Language of Schizophrenics and Drawing up Diagnostic Guidelines

2015 - 2018 自閉症スペクトラムと注意欠如・多動性障害の病態解明

2014 - 2017 Examination of Protective factor to facilitate social adjustment for Children with Autism Spectrum tendency

2012 - 2015 D1 receptor alteration and microglial activation in ADHD; PET study.

2012 - 2015 Abnormal activation and alterations in neuron density and neurotransmitters in the default mode network in autism

2013 - 2015 発達障害とトラウマ性発達障害の鑑別およびトラウマへの治療効果判定に関する研究

2011 - 2014 Functional analysis of microglia as a therapeutic target of schizophrenia

2010 - 2014 Alterations of synaptic transcytosis induced by ethanol exposure: non-vesicular synaptic transport in the rat

2011 - 2014 脳画像解析とCNV解析の融合による弧発性自閉症と家族性自閉症の病態解明

2011 - 2013 Investigation on mitochondrial dysfunction in autism.

2010 - 2012 Investigation of early sign and interventional point for pervasive developmental disorders by prospective study

2010 - 2012 Glutamate concentration in the brain of individuals with autism: A proton magnetic resonance spectroscopy study.

2010 - 2012 Molecular imaging study on dopaminergic system in autism: in relation to deficits in memory reconstruction

2010 - 2012 Involvement of brain-derived neurotrophic factor gene polymorphism on the central nervous system disorders of alcoholics

2010 - 2012 Frontal lobe abnormalities in alcoholics: a multimodal molecular imaging study

2010 - 2012 A study on the development of biological "veryearly"diagnosis of autism

2010 - 2012 Molecular imaging of cholinergic system in the brain of autism: A positron emission tomography study.

2010 - 2012 Predictors of autism including low birth weight and social cognitive impairment: a longitudinal epidemiological study

2010 - 2012 Comprehensive search of Treatment-resistant depression associated protein by time-controlled transcardiac perfusion cross-linking technique

2008 - 2011 Demonstration of serotonin hypothesis for autism by PET, and the identification and analysis of function on gene related to the control of serotonin synthesis

2008 - 2010 自閉症における共感性の障害に関する前帯状回機能不全仮説の脳画像的・遺伝学的検証

2008 - 2010 An association between advanced paternal age at birth and risk for autism spectrum disorders and the underlying biological mechanisms

2008 - 2010 analysis of serotonin transductional dysfunction in autism

2008 - 2010 Neuronal stem cell imaging and analysis of non-human primates brain

2007 - 2009 Research on production of a primate model for schizophrenia and development of transplant therapy by neural stem cell grafts

2007 - 2009 An epidemiological study of mental health in children and neuroimaging investigation : in view of social and emotional developments

2006 - 2009 Cytoarchitectural changes of brain induced by alcohol exposure : effects on Notch signal pathway

2006 - 2008 The study related to the neurophysical mechanism of high-functioning autism for using the method of neuroimaging and molecular biology

2006 - 2007 Neuroinflammation in the pathogenesis of autistic disorder

2006 - 2007 An exploratory study of neurostructural endophenotype among individuals with autistic disorder

2006 - 2007 Role of neurogenesis in the treatment of schizophrenia

2006 - 2007 統合失調症の二重衝撃仮説(Two hit hypothesis)の証明

2005 - 2007 The study related to the mechanism of the onset for methamphetamine dependence in Japanese and Taiwanese populations.

2005 - 2006 リーリンに着目した自閉症と統合失調症との比較研究

2005 - 2006 統合失調症病態解明のための仮死モデル

2005 - 2006 Methamphetamine Causes Reactive Microgliosis in the Brains of Human Abusers

2005 - 2006 Prepulse Inhibition of Acoustic Startle and Cognitive Functioning in Subjects with Schizophrenia

2005 - 2005 遅発性ジスキネジアに対する電気痙攣療法の効果に関する研究

2004 - 2005 Exploratory study of genetic phenotypes in schizophrenia with brain morphometry and ^1H-MRS

2003 - 2005 Implications of neural stem cells for the pathogenesis of schizophrenia : A new target for schizophrenia research

2003 - 2004 Serotonin transporter loss and psychotic state in methamphetamine users

2002 - 2003 精神分裂病における神経細胞分化に関わるポリシアル酸合成酵素の遺伝子多型と機能解析

2001 - 2002 鎮痛薬感受性の個人差とミューオピオイド受容体遺伝子配列との関連解析

2000 - 2002 Psychoactive substances metabolism and cytotoxicity in the brain and liver

2001 - 2001 イヌとヒト健康社会:動物介在療法の構築およびその効果の科学的評価法に関する研究

2001 - 2001 がん疼痛へのモルヒネ鎮痛効果と副作用出現の分子遺伝学的研究

1998 - 2001 Effects on neuronal formation of the hippocampus in developmental abnormalities

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Papers (236)：

Tomoya Hirota, Masaki Adachi, Rei Monden, Hiroyuki Mori, Michio Takahashi, Kazuhiko Nakamura. Examining the comorbidity network of Internet addiction and depression: the role of effortful control on their bridge symptoms in adolescents. Frontiers in psychiatry. 2025. 16. 1493888-1493888
Yui Sakamoto, Takeshi Takano, Shuji Shimoyama, Takeshi Hiramoto, Noboru Hiroi, Kazuhiko Nakamura. Prepartum bumetanide treatment reverses altered neonatal social communication but nonspecifically reduces postpubertal social behavior in a mouse model of fragile X syndrome. Genomic Psychiatry. 2024
Sumi Kato, Kazuaki Hanawa, Manabu Saito, Kazuhiko Nakamura. Creating a diagnostic assessment model for autism spectrum disorder by differentiating lexicogrammatical choices through machine learning. PLOS ONE. 2024. 19. 9. e0311209-e0311209
三上珠希, 大里絢子, 斉藤まなぶ, 照井藍, 坂本由唯, 三上美咲, 小枝周平, 中村和彦. A市における3歳児発達健診の5年間の経緯及び自閉スペクトラム症(ASD)の併存障害について. 日本児童青年精神医学会総会抄録集. 2023. 64回. P17-2
Noriko Miyake, Yoshinori Tsurusaki, Ryoko Fukai, Itaru Kushima, Nobuhiko Okamoto, Kei Ohashi, Kazuhiko Nakamura, Ryota Hashimoto, Yoko Hiraki, Shuraku Son, et al. Molecular diagnosis of 405 individuals with autism spectrum disorder. European journal of human genetics : EJHG. 2023

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MISC (208)：

照井藍, 斉藤まなぶ, 坂本由唯, 三上珠希, 大里絢子, 中村和彦. 5歳ASD児の睡眠の問題とメラトニンの関係. 精神神経学雑誌. 2024. 126. 6. 409-409
中村和彦. 神経発達症群の生物学的研究と子どもの疫学研究. 日本児童青年精神医学会総会抄録集. 2023. 64回. np1-np1
坂本由唯, 斉藤まなぶ, 大里絢子, 照井藍, 三上珠希, 中村和彦. 新型コロナウイルス禍による経済的影響と発達特性を有する5歳児のメンタルヘルス. 日本児童青年精神医学会総会抄録集. 2023. 64回. np87-np87
照井藍, 斉藤まなぶ, 坂本由唯, 三上珠希, 大里絢子, 中村和彦. 地域における3歳児の調査での、社会性の発達に遅れのある子どもの睡眠習慣と行動の問題との関連. 日本児童青年精神医学会総会抄録集. 2023. 64回. O14-1
廣田智也, 斉藤まなぶ, 坂本由唯, 中村和彦. 母子手帳のさらなる科学的活用にむけて. 日本児童青年精神医学会総会抄録集. 2023. 64回. O14-2

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Books (7)：

子どものこころの診療のコツ研究のコツ
金剛出版 2023 ISBN:9784772420068
児童・青年期精神疾患の薬物治療ガイドライン
じほう 2018 ISBN:4840751129
大人のADHD臨床: アセスメントから治療まで
金子書房 2016 ISBN:4760821732
子どものこころの医学
金芳堂 2014 ISBN:4765316092
CAARS : 日本語版マニュアル
金子書房 2012

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Lectures and oral presentations (11)：

自閉スペクトラム症における遂行機能障害の神経基盤の解明
(第45回日本脳科学会 2018)
自閉スペクトラム症児者のライフステージに応じた“つながる”支援
(2017年度一般社団法人日本LD学会公開シンポジウム 2017)
自閉スペクトラム症児者の理解
(2017年度一般社団法人日本LD学会公開シンポジウム 2017)
The effect of chronic diazepam administration induced upregulation of Lcn2 expression on cognitive function
(第44回日本脳科学会 2017)
AP-1 complex induces mouse Tspo gene expression by lipopolysaccharide in microglial cell line, BV-2.
(第44回日本脳科学会 2017)

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Education (2)：

1990 - 1994 Kagawa Medical University
1984 - 1990 Kagawa Medical University

Professional career (1)：

医学博士 (香川医科大学)

Work history (5)：

2013/01 - 現在 Hirosaki University Graduate School of Medicine
2009 - 2012/12 Hamamatsu University School of Medicine
2002 - 2009 Hamamatsu University School of Medicine
2000 - 2002 東京都精神医学総合研究所臨床心理研究部門研究員
1998 - 2000 Kagawa Medical University

Awards (2)：

2004 - 2004年度日本臨床精神神経薬理学会奨励賞アスペルガー症候群における脳内セロトニン・トランスポーター密度に対するPETを用いた研究
1999 - 第6回日本アルコール薬物医学会優秀論文賞アルコール慢性投与マウスの脳内のアセトアルデヒドアダクトについて

Association Membership(s) (5)：

日本精神神経学会 , The Japanese Society for Child and Adolescent Psychiatry , JAPANESE SOCIETY OF BIOLOGICAL PSYCHIATRY , THE JAPANESE SOCIETY OF NEUROPSYCHOPHARMACOLOGY , JAPAN BRAIN SCIENCE SOCIETY

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