Research field (6)：
Metabolism and endocrinology
, Internal medicine - General
, Pharmaceuticals - chemistry and drug development
, Pharmacology
, Cell biology
, Molecular biology
2019 - 2022 Preventive and therapeutic significance of CD52 in metabolic diseases with obesity
2018 - 2021 Mechanism of adipose angiogenesis by the cooperative action of angiogenic factors
2015 - 2018 Studies on novel insulin-sensitizing agent based on SHIP2 inhibitors
2015 - 2018 Development of therapeutic strategy against obesity-associated chronic inflammations based on the mechanism involved in sex-specific difference of Treg localization in adipose tissue.
2015 - 2017 Impact of the cooperative effect of estrogen and orexin on abnormalities with emotion and metabolism in menopausal mice
2012 - 2016 Development of therapeutics for diabetes with dysregulation of sleep/wake rhythm and depressive disorders by timed regulation of hypothalamic orexin system
2013 - 2015 Role of estrogen via the recruitment of Treg in the control of glucose homeostasis in female mice.
2013 - 2015 Development of a new estrogen replacement therapy based on a central action of a menopausal metabolic disorder and depression
2011 - 2012 Development of a new therapeutics of gestational diabetes by inhibition of the central action of lipid phosphatase
Hiroshi Tsuneki, Masanori Sugiyama, Kiyofumi Sato, Hisakatsu Ito, Sanaka Nagai, Kanta Kon, Tsutomu Wada, Nao Kobayashi, Takuya Okada, Naoki Toyooka, et al. Resting phase-administration of lemborexant ameliorates sleep and glucose tolerance in type 2 diabetic mice. European journal of pharmacology. 2023. 961. 176190-176190
Hye-Jin Lee, Bo-Yeong Jin, Mi-Rae Park, Nam Hoon Kim, Kwan Sik Seo, Yong Taek Jeong, Tsutomu Wada, Jun-Seok Lee, Sang-Hyun Choi, Dong-Hoon Kim. Inhibition of adipose tissue angiogenesis prevents rebound weight gain after caloric restriction in mice fed a high-fat diet. Life sciences. 2023. 332. 122101-122101
Tsutomu Wada, Yuichiro Miyazawa, Misa Ikurumi, Kento Fuse, Akira Okekawa, Yasuhiro Onogi, Shigeru Saito, Hiroshi Tsuneki, Toshiyasu Sasaoka. A transdermal treatment with MC903 ameliorates diet-induced obesity by reducing visceral fat and increasing myofiber thickness and energy consumption in mice. Nutrition & Metabolism. 2023. 20. 1. 10-10
Z. Polianskyte-Prause, T. A. Tolvanen, S. Lindfors, K. Kon, H. Wang, V. Dumont, P-H. Groop, T. Wada, H. Tsuneki, T. Sasaoka, et al. Novel small molecules targeting lipid phosphatase SHIP2: new treatments for type 2 diabetes. DIABETOLOGIA. 2017. 60. S226-S227
Akari Ishikawa, Tsutomu Wada, Eri Watanabe, Hayate Hasegawa, Yuto Nakamura, Hiroshi Tsuneki, Yoko Ishii, Masakiyo Sasahara, Toshiyasu Sasaoka. Impact of Mineralocorticoid Receptor Blockade on Energy Metabolism and NLRP3-Inflammasome Activation in Diet-Induced Obese Mice. DIABETES. 2017. 66. A541-A542
Watanabe Eri, Wada Tsutomu, Onogi Yasuhiro, Tsuneki Hiroshi, Sasaoka Toshiyasu. Anagliptin, a DPP-4 Inhibitor, Attenuates Diet-Induced Obesity by Modulating Adipose Tissue Angiogenesis in Mice. DIABETES. 2017. 66. A541-A541
