Nishiya Naoyuki

ニシヤナオユキ | Nishiya Naoyuki

Affiliation and department：
Job title： Professor

Research field (3)： Pharmaceuticals - chemistry and drug development , Pharmacology , Pharmaceuticals - health and biochemistry

Research keywords (5)：ケミカルバイオロジー , シグナル伝達 , 細胞接着 , Signal transduction , Cell adhesion

Research theme for competitive and other funds (22)：

2021 - 2024 Development of a new macrolide derivative targeting mTORC
2019 - 2022 Development of A- and F-ring-modified lamellarin type inhibitors effective for C797S mutated EGFR
2018 - 2020 mTORC構成因子Tel2を標的とした創薬の基盤構築
2016 - 2018 Approach of production of dental epithelial cells from periodontal ligament mesenchymal cells for tooth regeneration
2014 - 2017 Development of EGFR-Tyrosine Kinase Inhibitors Effective for Non-Small Cell Lung Cancer Resistant to Gefitinib

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Papers (38)：

Haruki Ujiie, Naoyuki Nishiya, Ami Yamamoto, Takeru Takada, Megumi Onodera, Ayana Sasaki, Takuya Oikawa. Dexamethasone reduces cisplatin-induced hair cell damage by inducing cisplatin resistance through metallothionein-2. Cancer chemotherapy and pharmacology. 2024. 94. 4. 561-569
Hiroshi Katagiri, Honami Yonezawa, Sho Shitamura, Aoi Sugawara, Tomikazu Kawano, Makoto Maemondo, Naoyuki Nishiya. A Wnt/β-catenin signaling inhibitor, IMU1003, suppresses the emergence of osimertinib-resistant colonies from gefitinib-resistant non-small cell lung cancer cells. Biochemical and biophysical research communications. 2023. 645. 24-29
Honami Yonezawa, Akari Ikeda, Ryo Takahashi, Haruka Endo, Yasuyo Sugawara, Mikako Goto, Mirute Kanno, Sosuke Ogawa, Karin Nakamura, Haruki Ujiie, et al. Ivermectin represses Wnt/β-catenin signaling by binding to TELO2, a regulator of phosphatidylinositol 3-kinase-related kinases. iScience. 2022. 25. 3. 103912-103912
Naoyuki Nishiya, Honami Yonezawa. Domestication of chemicals attacking metazoan embryogenesis: identification of safe natural products modifying developmental signaling pathways in human. The Journal of Antibiotics. 2021. 74. 10. 651-659
HARUKI UJIIE, SATORU NIHEI, NAOYUKI NISHIYA, SHINPEI GOTO, YOSHIKO ASAKURA, SHOKO MIURA, DAISHI HIRAI, MIKIYA ENDO, TATSUO OYAKE, SHIGEKI ITO, et al. Switching from Intravenous to Oral Tacrolimus Reduces its Blood Concentration in Paediatric Cancer Patients. Anticancer Research. 2021. 41. 5. 2591-2596

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Patents (2)：

Books (3)：

Lectures and oral presentations (18)：

発生異常表現型を利用した抗がん剤標的分子の同定
(第68回日本薬学会関東支部大会 2024)
ゼブラフィッシュ胚の表現型解析を起点としたドラッガブル分子の同定
(日本薬学会東北支部第 45 回東北薬学セミナー 2023)
健康長寿に危機をもたらす薬剤耐性
(岩手医科大学第41回市民公開講座 2023)
Wnt経路を制御する化合物と標的分子
(第30回産学連携フォーラム 2022)
ゼブラフィッシュ胚の表現型ダイバーシティーを利用したケミカルバイオロジー
(新学術領域「細胞ダイバース」公開シンポジウム 2021)

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Professional career (1)：

Work history (8)：

2017/07 - 現在 Iwate Medical University School of Pharmacy Professor
2017/01 - 2017/06 Iwate Medical University School of Pharmacy Associate Professor
2007/10 - 2016/12 Iwate Medical University School of Pharmacy
2006 - 2007 (独)理化学研究所脳科学総合研究センター基礎科学特別研究員
2006 - 2007 University of California, San Diego

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Committee career (5)：

Association Membership(s) (7)：

JAPANESE SOCIETY FOR CHEMICAL BIOLOGY , The American Society for Cell Biology , がん分子標的治療研究会 , 日本薬学会 , 日本分子生物学会 , 日本細胞生物学会 , 日本癌学会

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