Nakamura Takeshi

Affiliation and department：
Homepage URL (1)： http://www.rs.noda.tus.ac.jp/~ribsnlab/index.html

Research field (2)： Medical biochemistry , Neuroscience - general

Research keywords (59)： Rab5 , 細胞運動 , 細胞増殖情報伝達系 , Akt , Ral , transformation , 分子時空間計測 , MEK , ERK , Rac , R-Ras , Rac1 , アポトーシス , Rapl , simulation , signal , イノシトールリン脂質 , Rhoファミリー低分子量Gタンパク質 , transduction , 低分子量G蛋白 , 小胞輸送 , タンパク質相互作用 , 細胞増殖 , セリンスレオニンキナーゼ , Asef , MAPK , Raf , 分子生物学 , 形態形成 , 統計解析 , システム生物学 , Ras , G蛋白 , 神経突起伸展 , 可視化 , 海馬神経細胞 , Rhoファミリー , 神経回路 , 細胞・組織 , フィードバック , 蛋白質 , 神経細胞 , Rho , 神経回路形成 , G蛋白質 , PIP_3 , Racl , 成長円錐 , RNAi , Rasファミリー , SHIP2 , 神経成長因子 , FRETプローブ , PI3キナーゼ , 神経科学 , イメージング , シミュレーション , シグナル伝達 , FRET

Research theme for competitive and other funds (17)：

2020 - 2023 Mechanism of G protein signals regulating bi-directional axon transport and axon growth, regeneration and degeneration
2015 - 2018 Analysis of molecular network regulating spatiotemporal activities of three G proteins that control membrane traffic during outgrowth of growth cones
2013 - 2016 Development of the Near-infrared Differential Laser-induced Surface Deformation Microscope and its Application to the Measurements on Rheological Properties of Single Living Cells
2010 - 2016 Multidimendional FRET imaging of intracellular signal transduction
2012 - 2012 Analysis of the regulation-mechanism of intracellular dynamics of late endosome and lysosome by using a FRET biosensor

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Papers (36)：

Shingo Koinuma, Ryota Negishi, Riko Nomura, Kazuki Sato, Takuya Kojima, Eri Segi-Nishida, Ryo Goitsuka, Yoichiro Iwakura, Naoyuki Wada, Yoshiki Koriyama, et al. TC10, a Rho family GTPase, is required for efficient axon regeneration in a neuron-autonomous manner. Journal of neurochemistry. 2020. 157. 4. 1196-1206
So Morishita, Naoyuki Wada, Mitsunori Fukuda, Takeshi Nakamura. Rab5 activation on macropinosomes requires ALS2, and subsequent Rab5 inactivation through ALS2 detachment requires active Rab7. FEBS Letters. 2019. 593. 2. 230-241
Kanemitsu-Fujita, A, Morishita, S, Kjaer, S, Fukuda, M, Schiavo, G, Nakamura, T. Comparable affinity of RabGDIα for GTP- and GDP-bound forms of Rab7 supports a four-state transition model for Rab7 subcellular localization. bioRxiv. 2018. 287516
Shingo Koinuma, Kohei Takeuchi, Naoyuki Wada, Takeshi Nakamura. cAMP-induced activation of protein kinase A and p190B RhoGAP mediates down-regulation of TC10 activity at the plasma membrane and neurite outgrowth. GENES TO CELLS. 2017. 22. 11. 953-967
Yasuda, S, Morishita, S, Fujita, A, Nanao, T, Wada, N, Waguri, S, Schiavo, G, Fukuda, M, Nakamura, T. Mon1-Ccz1 activates Rab7 only on late endosomes and dissociates from the lysosome in mammalian cells. J. Cell Sci. 2016. 129. 2. 329-340

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MISC (12)：

Takeshi Nakamura, Akihiro Goto, Michiyuki Matsuda, Tatsuo Kinashi. Rap1B plays an instructive role in neuronal polarization through RalA and Nore1A in addition to PI3-kinase. NEUROSCIENCE RESEARCH. 2010. 68. E137-E137
Akihiro Goto, Takeshi Nakamura, Mikio Hoshino, Michiyuki Matsuda. FRET analysis of differences in signaling mechanism between dbcAMP- and NGF-induced neuritogenesis in PC12D cells. NEUROSCIENCE RESEARCH. 2010. 68. E249-E250
中村岳史, 北野正寛, 仲矢道雄, 長田重一, 松田道行. 【感染現象その理解の深化から疾患制御への展望】生体防御機構研究の新展開貪食過程における低分子量G蛋白質Rac1とRab5の活性変化. 蛋白質・核酸・酵素. 2009. 54. 8. 1114-1118
Akihiro Goto, Takeshi Nakamura, Michiyuki Matsuda. Differences in signaling mechanism and morphological change between dbcAMP- and NGF-induced neuritogenesis in PC12D cells. NEUROSCIENCE RESEARCH. 2009. 65. S45-S45
T. Nakamura, K. Aoki, M. Matsuda. FRET imaging and in silico analysis of nerve growth factor-induced neurite outgrowth. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE. 2008. 26. 8. 882-882

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Professional career (1)：

理学博士

Work history (7)：

2007 - 2010 京都大学生命科学研究科講師
2008 - 京都大学大学院・生命科学研究科講師
2007 - 京都大学大学院・医学研究科講師
2007 - 京都大学医学(系)研究科(研究院) 講師
2004 - 2006 Osaka University Research Institute for Microbial Diseases

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Association Membership(s) (4)：

BIOIMAGING SOCIETY , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE SOCIETY FOR NEUROCHEMISTRY , THE JAPAN NEUROSCIENCE SOCIETY

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