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J-GLOBAL ID：200901089853828121   Update date: Mar. 28, 2025

Nakamura Takeshi

Nakamura Takeshi
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Affiliation and department：
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About -


Homepage URL  (1)： http://kir628906.kir.jp/index.html
Research field  (2)： Medical biochemistry ,  Neuroscience - general
Research keywords  (59)： Rab5 ,  細胞運動 ,  細胞増殖情報伝達系 ,  Akt ,  Ral ,  transformation ,  分子時空間計測 ,  MEK ,  ERK ,  Rac ,  R-Ras ,  Rac1 ,  アポトーシス ,  Rapl ,  simulation ,  signal ,  イノシトールリン脂質 ,  Rhoファミリー低分子量Gタンパク質 ,  transduction ,  低分子量G蛋白 ,  小胞輸送 ,  タンパク質相互作用 ,  細胞増殖 ,  セリンスレオニンキナーゼ ,  Asef ,  MAPK ,  Raf ,  分子生物学 ,  形態形成 ,  統計解析 ,  システム生物学 ,  Ras ,  G蛋白 ,  神経突起伸展 ,  可視化 ,  海馬神経細胞 ,  Rhoファミリー ,  神経回路 ,  細胞・組織 ,  フィードバック ,  蛋白質 ,  神経細胞 ,  Rho ,  神経回路形成 ,  G蛋白質 ,  PIP_3 ,  Racl ,  成長円錐 ,  RNAi ,  Rasファミリー ,  SHIP2 ,  神経成長因子 ,  FRETプローブ ,  PI3キナーゼ ,  神経科学 ,  イメージング ,  シミュレーション ,  シグナル伝達 ,  FRET
Research theme for competitive and other funds  (17)：
  • 2020 - 2023 Mechanism of G protein signals regulating bi-directional axon transport and axon growth, regeneration and degeneration
  • 2015 - 2018 Analysis of molecular network regulating spatiotemporal activities of three G proteins that control membrane traffic during outgrowth of growth cones
  • 2013 - 2016 Development of the Near-infrared Differential Laser-induced Surface Deformation Microscope and its Application to the Measurements on Rheological Properties of Single Living Cells
  • 2010 - 2016 Multidimendional FRET imaging of intracellular signal transduction
  • 2012 - 2012 Analysis of the regulation-mechanism of intracellular dynamics of late endosome and lysosome by using a FRET biosensor
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Papers (38)：
  • Shingo Koinuma, Misa Miyaji, Suzuka Akiyama, Yasuyuki Ito, Hiroshi Takemura, Naoyuki Wada, Michihiro Igarashi, Takeshi Nakamura. TC10 on endosomes regulates the local balance between microtubule stability and dynamics through the PAK2-JNK pathway and promotes axon outgrowth. Journal of Cell Science. 2025. 138. 4
  • Katsuyuki Kunida, Nobuhiro Takagi, Kazuhiro Aoki, Kazushi Ikeda, Takeshi Nakamura, Yuichi Sakumura. Decoding cellular deformation from pseudo-simultaneously observed Rho GTPase activities. Cell reports. 2023. 112071-112071
  • Shingo Koinuma, Ryota Negishi, Riko Nomura, Kazuki Sato, Takuya Kojima, Eri Segi-Nishida, Ryo Goitsuka, Yoichiro Iwakura, Naoyuki Wada, Yoshiki Koriyama, et al. TC10, a Rho family GTPase, is required for efficient axon regeneration in a neuron-autonomous manner. Journal of neurochemistry. 2020. 157. 4. 1196-1206
  • So Morishita, Naoyuki Wada, Mitsunori Fukuda, Takeshi Nakamura. Rab5 activation on macropinosomes requires ALS2, and subsequent Rab5 inactivation through ALS2 detachment requires active Rab7. FEBS Letters. 2019. 593. 2. 230-241
  • Kanemitsu-Fujita, A, Morishita, S, Kjaer, S, Fukuda, M, Schiavo, G, Nakamura, T. Comparable affinity of RabGDIα for GTP- and GDP-bound forms of Rab7 supports a four-state transition model for Rab7 subcellular localization. bioRxiv. 2018. 287516
ｍore...
MISC (12)：
  • Takeshi Nakamura, Akihiro Goto, Michiyuki Matsuda, Tatsuo Kinashi. Rap1B plays an instructive role in neuronal polarization through RalA and Nore1A in addition to PI3-kinase. NEUROSCIENCE RESEARCH. 2010. 68. E137-E137
  • Akihiro Goto, Takeshi Nakamura, Mikio Hoshino, Michiyuki Matsuda. FRET analysis of differences in signaling mechanism between dbcAMP- and NGF-induced neuritogenesis in PC12D cells. NEUROSCIENCE RESEARCH. 2010. 68. E249-E250
  • 中村 岳史, 北野 正寛, 仲矢 道雄, 長田 重一, 松田 道行. 【感染現象 その理解の深化から疾患制御への展望】生体防御機構研究の新展開 貪食過程における低分子量G蛋白質Rac1とRab5の活性変化. 蛋白質・核酸・酵素. 2009. 54. 8. 1114-1118
  • Akihiro Goto, Takeshi Nakamura, Michiyuki Matsuda. Differences in signaling mechanism and morphological change between dbcAMP- and NGF-induced neuritogenesis in PC12D cells. NEUROSCIENCE RESEARCH. 2009. 65. S45-S45
  • T. Nakamura, K. Aoki, M. Matsuda. FRET imaging and in silico analysis of nerve growth factor-induced neurite outgrowth. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE. 2008. 26. 8. 882-882
ｍore...
Professional career (1)：
  • 理学博士
Work history (7)：
  • 2007 - 2010 京都大学 生命科学研究科 講師
  • 2008 - 京都大学 大学院・生命科学研究科 講師
  • 2007 - 京都大学 大学院・医学研究科 講師
  • 2007 - 京都大学 医学(系)研究科(研究院) 講師
  • 2004 - 2006 Osaka University Research Institute for Microbial Diseases
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Association Membership(s) (4)：
BIOIMAGING SOCIETY ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  THE JAPANESE SOCIETY FOR NEUROCHEMISTRY ,  THE JAPAN NEUROSCIENCE SOCIETY
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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