Hosaka Masahiro

ホサカマサヒロ | Hosaka Masahiro

Affiliation and department：
Homepage URL (1)： http://www.akita-pu.ac.jp/bioresource/dbt/molb/mhosaka/index.html

Research field (6)： Metabolism and endocrinology , Neuroscience - general , Functional biochemistry , Molecular biology , Chemical biology , Cell biology

Research keywords (7)： responses for oxygen in neuro-endocrine cells , peptide hormone , secretory granule , synaptic vesicle , bio-imaging , hypoxia , Endocrine

Research theme for competitive and other funds (22)：

2024 - 2027 セクレトグラニンに依存しない分泌顆粒へのホルモン選別輸送機構を探索する
2020 - 2024 負荷で顕在化するホルモン分泌不全の謎:グラニン蛋白欠損マウスから生活習慣病に迫る
2021 - 2024 ホルモン前駆体と活性化酵素群が出会う仕組み:グラニンを介した共輸送機構の解明
2018 - 2021 内分泌細胞の酸素応答とホルモン生合成・分泌制御のクロストークを解明する
2016 - 2018 イリジウム錯体の特性を活かしNash病巣を描出する新規生体イメージング技法の確立

2014 - 2017 Diversity in the global organization of the Golgi apparatus in differentiated secretory cells.

2013 - 2015 Study for protein binding to the cholesterol-rich secretory granule membrane in neuroendocrine cells

2010 - 2012 Characteristics in the overall organization and dynamics of the Golgi apparatus in the anterior pituitary endocrine cells.

2010 - 2012 The cholesterol metabolism of neuroendocrine cells and crosstalk of the hormone secretion

2009 - 2011 Research and development of hypoxia-detecting luminescent probe iridium complex and its application to endoscopic imaging probes

2009 - 2011 Phosphorescent Light-emitting lridium Complexes Serve as a Hypoxia-sensing Probe for Tumor Imaging in Living Animals.

2006 - 2008 Effects of LHRH analogues on the ultrastructure of male rat pituitary gonadotropes

2006 - 2007 The formation mechanisms of secretory granules and synaptic-like micro-vesicles by the lead of cholesterol in endocrine cells.

2004 - 2005 神経内分泌細胞の調節性分泌経路へのタンパク質選別輸送機構の解明

2003 - 2004 A study for the sorting mechanism of proteins to Secretory Granules in Neuroendocrine cells : Emerging Concepts with Granins.

2001 - 2002 The study for the function of synapsins in Synaptic vesicles and secretory granules

1999 - 2000 Roles for Synapsins in Regulation of Synaptic Vesicle Traffic.

低酸素病態イメージングプローブの開発・実用化

トランスゴルジネットワークにおけるタンパク質の選別輸送機構

内分泌細胞の分泌顆粒形成について

Mechanism of Sorting in Trans-Golgi Network

Formation of Secretory Granule from TGN.

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Papers (82)：

Tadashi Yasui, Mutsumi Mashiko, Akihiro Obi, Hiroyuki Mori, Moeko Ito-Murata, Hiroki Hayakawa, Shota Kikuchi, Masahiro Hosaka, Chisato Kubota, Seiji Torii, et al. Insulin granule morphology and crinosome formation in mice lacking the pancreatic β cell-specific phogrin (PTPRN2) gene. Histochemistry and Cell Biology. 2024. ahead of print
Kubota C., Torii R., Hosaka M., Takeuchi T., Gomi H., Torii S. Phogrin Regulates High-Fat Diet-Induced Compensatory Pancreatic β-Cell Growth by Switching Binding Partners. Nutrients. 2024. 16. 1. 169-169
Hiroshi Gomi, Takahiro Nagumo, Kazushi Asano, Makoto Konosu, Tadashi Yasui, Seiji Torii, Masahiro Hosaka. Differential Expression of Secretogranins II and III in Canine Adrenal Chromaffin Cells and Pheochromocytomas. Journal of Histochemistry & Cytochemistry. 2022. 70. 5. 335-356
Hiroshi Gomi, Airi Hinata, Tadashi Yasui, Seiji Torii, Masahiro Hosaka. Expression Pattern of the LacZ Reporter in Secretogranin III Gene-trapped Mice. Journal of Histochemistry & Cytochemistry. 2021. 002215542199684-002215542199684
Eri Sato, Yoshinori Maeda, Yui Sato, Airi Hinata, Hiroshi Gomi, Daisuke Koga, Seiji Torii, Tsuyoshi Watanabe, Masahiro Hosaka. Culture in 10% O2 enhances the production of active hormones in neuro-endocrine cells by up-regulating the expression of processing enzymes. Biochemical Journal. 2019. 476. 5. 827-842

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MISC (40)：

久保田知里, 久保田知里, 齊藤直也, 河野あゆみ, 竹内利行, 小林雅樹, 北村忠弘, 穂坂正博, 五味浩司, 鳥居征司. 分泌顆粒蛋白質フォグリンによるインスリン分泌とシグナルの連結機構. 日本生化学会大会(Web). 2018. 91st
佐藤瑛理, 前田佳紀, 暮地本宙己, 渡部剛, 穂坂正博. 内分泌細胞および内分泌組織の低酸素環境におけるホルモン修飾の解析. 日本生化学会大会プログラム・講演要旨集. 2016. 89回. [1P-026]
佐藤瑛理, 前田佳紀, 暮地本宙己, 渡部剛, 穂坂正博. 脳下垂体内分泌細胞の低酸素環境におけるACTH分泌について. 日本生化学会大会(Web). 2015. 88th. 2P0218 (WEB ONLY)-[2P0218]
前田佳紀, 工藤咲希, 暮地本宙己, 村田知里, 鳥居征司, 渡部剛, 穂坂正博. セクレトグラニンIIIが膵島インスリン生合成と分泌で果たす役割について. 日本生化学会大会(Web). 2015. 88th. 1P1198 (WEB ONLY)-[1P1198]
吉原利忠, 穂坂正博, 竹内利行, 飛田成史. りん光性イリジウム錯体を用いた細胞・組織内酸素レベル計測. 生体医工学. 2015. 53. S138_01-S138_01

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Patents (10)：

含ケイ素置換基を導入した化合物、並びにそれを含む一重項酸素発生剤及び癌治療薬
新規化合物およびそれを含む機能性発光プローブ
COMPOUND AND FUNCTIONAL LUMINESCENT PROBE COMPRISING THE SAME(新規化合物およびそれを含む機能性発光プローブ)
新規水溶性イリジウム錯体化合物およびそれを用いた酸素濃度測定試薬
新規錯体化合物、並びにそれを用いた酸素濃度測定試薬および癌の診断薬

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Books (3)：

生活習慣病最前線
上毛新聞社 2012
群馬に多い病気
上毛新聞社 2007
新時代への視点
上毛新聞社 2006

Lectures and oral presentations (18)：

Redundancy in sorting systems destined for secretory granules ensure the regulated secretion of peptide hormones.
(2022)
Sorting Mechanisms of Prohormones from the Trans-Golgi Network to Secretory Granules: Concepts with Granin-Family Protein
(2019)
Sorting Mechanisms of Prohormones from the Trans-Golgi Network to Secretory Granules: Concepts with Granin-Family Protein
(2018)
Golgi Apparatus Structures and Function: Sorting Mechanisms of Prohormones from the Trans-Golgi Network to Secretory Granules: Concepts with Granin-Family Protein.
(Gordon Research Conferences; (New London, U.S.A.) 2014)
ホルモンがゴルジ体から分泌顆粒へソーティングされる機構
(第115回解剖学会 2010)

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Education (3)：

1992 - 1995 Ph.D: University of Tsukuba
1990 - 1992 MS.: University of Tsukuba
1986 - 1990 BS.: University of Tsukuba

Professional career (3)：

Ph.D. (University of Tsukuba)
M.S. (University of Tsukuba)
B.S. (University of Tsukuba)

Work history (7)：

2011/04 - 現在 Akita Prefectural University Faculty of Bioresource Sciences
2004/04 - 2011/03 Gunma University Institute for Molecular and Cellular Regulation
1999/07 - 2004/03 Gunma University Institute for Molecular and Cellular Regulation
1998/04 - 1999/06 University of Texas Southwestern medical Institute at Dallas HHMI resercher
1996/04 - 1998/03 University of Texas HFSP researcher

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Committee career (3)：

2015/07 - 現在日本生化学会評議員
2012/06 - 現在日本生化学会東北支部評議員
2016 - 2017 日本生化学会代議員

Awards (5)：

金原一郎記念医学医療振興財団研究助成金
上原記念生命科学財団研究奨励金
中島記念国際交流財団研究助成
日本糖尿病財団研究助成金
病態代謝研究会研究助成金

Association Membership(s) (6)：

Endocrine Society , THE JAPANESE BIOCHEMICAL SOCIETY , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , Japanese Society FOR Molecular Imaging , JAPAN SOCIETY FOR CELL BIOLOGY , 日本下垂体研究会

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