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J-GLOBAL ID：200901090338697985
Update date: Feb. 06, 2025 Yokoyama Takeshi
ヨコヤマ タケシ | Yokoyama Takeshi
University of Toyama Graduate School of Medicine and Pharmaceutical Sciences for Research
About University of Toyama Graduate School of Medicine and Pharmaceutical Sciences for Research
Research field (6)：
Molecular biology
, Biophysics
, Pharmaceuticals - analytical and physicochemistry
, Biophysics
, Functional biochemistry
, Structural biochemistry
Research theme for competitive and other funds (9)： - 2022 - 2025 中性子回折を用いたSIRT5の脱スクシニル反応におけるプロトン移動経路解明
- 2019 - 2022 Development of a selective BRD4 inhibitor by neutron protein crystallographic analysis
- 2020 - 多標的スクリーニングを用いた医薬品再開発による希少疾患治療戦略
- 2016 - 2019 Development of a TTR amyloidogenesis inhibitor based on the capture of transthyretin monomers
- 2015 - 2018 Structure and function of a signal protein osteocalcin connncting bone metabolism and carbohydrate metabollism
Show all
- Takeshi Yokoyama, Satoru Fujiwara, Kai Nishikubo, Mineyuki Mizuguchi, Yuko Nabeshima, Naoki Toyooka, Takuya Okada, Yusuke Nakagawa. Repurposing of Agrochemicals as ATTRv Amyloidosis Inhibitors. Journal of medicinal chemistry. 2025. 68. 2. 1572-1586
- Nguyen Ngoc Thanh Luan, Takuya Okada, Takeshi Yokoyama, Mie Suzuki, Yuko Nabeshima, Mineyuki Mizuguchi, Naoki Toyooka. Divergent Total Synthesis of Isoflavone Natural Products and Their Potential as Therapeutic Agents for TTR Amyloidosis. Journal of natural products. 2024. 87. 11. 2604-2614
- Takeshi Yokoyama, Kotono Hisatomi, Saki Oshima, Ichiro Tanaka, Takuya Okada, Naoki Toyooka. Discovery and optimization of isoliquiritigenin as a death-associated protein kinase 1 inhibitor. European journal of medicinal chemistry. 2024. 279. 116836-116836
- Tomonao Inobe, Runa Sakaguchi, Takayuki Obita, Atushi Mukaiyama, Seiichi Koike, Takeshi Yokoyama, Mineyuki Mizuguchi, Shuji Akiyama. Structural insights into rapamycin-induced oligomerization of a FRB-FKBP fusion protein. FEBS letters. 2024
- Takeshi Yokoyama, Yuki Takayama, Mineyuki Mizuguchi, Yuko Nabeshima, Katsuhiro Kusaka. SIRT5 mutants reveal the role of conserved asparagine and glutamine residues in the NAD+-binding pocket. FEBS letters. 2024
- 日下勝弘, 横山武司, 山田太郎, 矢野直峰, 田中伊知朗, 水口峰之. Neutron structure analysis of TTR variant Y116S & Y116V by using iBIX. 量子ビームサイエンスフェスタ(Web). 2022. 2021
- 瀬川良佑, 竹田浩之, 横山武司, 石田桃葉, 宮田千優, 斉藤大将, 石原涼介, 中北智哉, 笹野祐介, 叶直樹, et al. Identification of action targets that contribute to the suppression of TSLP expression by chalcone derivatives. 日本薬学会年会要旨集(Web). 2022. 142nd
- 横山武司. ドラッグ・リポジショニングによる抗ATTRアミロイドーシス薬の探索研究. ファルマシア(Web). 2022. 58. 8
- 中川裕介, 乾貴信, 北上龍太, 片山稚那, 島根彩華, 岡田卓哉, 横山武司, 横山武司, 水口峰之, 水口峰之, et al. 難病アミロイド病治療薬の探索:新規フラバノン誘導体の合成およびX線結晶構造解析を用いた構造最適化. 創薬懇話会講演要旨集. 2021. 2021
- 横山武司, 藤井志帆, OSTERMANN Andreas, SCHRADER Tobias E, 鍋島裕子, 水口峰之. Hsp72-NBD-ADP複合体の中性子結晶構造解析. 日本結晶学会年会講演要旨集. 2021. 2021
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創薬標的タンパク質の中性子結晶構造解析
(第57回日本生物物理学会年会 2019) -
Identification of Purpurin as DAPK1 Inhibitor and X-ray Structural Analysis of DAPK1-Purpurin Complex
(日本薬学会北陸支部第129回例会 2017) -
中性子結晶解析によるHSP70内部の水和構造の可視化
(日本薬学会北陸支部第129回例会 2017) -
FPPS-ビスホスホネート複合体におけるプロトン化状態の変化と水和構造
(平成28 年度J-PARC/MLF 産業利用報告会 2016) -
トランスサイレチン型アミロイドーシスの治療を目指した構造生物学的研究
(第1051回金曜セミナーおよび第4回neutrons in biology研究会 2016)
- 2003 - 2006 Yokohama City University
- 2001 - 2003 Yokohama City University
- 1997 - 2001 Osaka University
- 理学(博士) (横浜市立大学)
- 2011/06 - 現在 University of Toyama
- 2008/06 - 2011/05 Ibaraki University Frontier Research Center for Applied Atomic Sciences
- 2006/04 - 2008/05 University of Houston Department of Biology and Biochemistry
- 2015/04 - 2020/03 公益財団法人 新世代研究所 水和ナノ構造研究会
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