Tsukano Chihiro

ツカノチヒロ | Tsukano Chihiro

Affiliation and department：
Job title： Assistant Professor,Assistant Professor

Research field (5)： Bioorganic chemistry , Pharmaceuticals - chemistry and drug development , Molecular biochemistry , Synthetic organic chemistry , Biochemistry

Research keywords (3)： Organic Chemistry , Natural Product Synthesis , Synthetic Chemistry

Research theme for competitive and other funds (12)：

2023 - 2026 Development to ultra-early diagnosis and prevention of AD by using a specific antibody against the toxic conformation of amyloid beta
2021 - 2024 機能性食品由来・未開拓新奇トリテルペノイドの全合成
2021 - 2023 大環状天然物の立体配座制御による高選択的な抗HIVシーズの開発
2017 - 2022 Unified comprehension of chemical communication by natural PKC ligands and development of new medicinal seeds
2017 - 2021 Total synthesis of natural products with unique and complex structures based on transformation of multi-substituted cyclopropanes

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Papers (75)：

Mako Aoki, Hiroto Takarada, Jumpei Maki, Takumi Kobayashi, Chihiro Tsukano, Kazuhiro Irie. Convergent Synthesis of Antitumor Aplysiatoxin Derivatives Based on a Combination of Ring-closing and Cross Metathesis. European Journal of Organic Chemistry. 2024
Chihiro Tsukano, Ayumi Uchino, Kazuhiro Irie. Synthesis and Applications of Symmetric Amino Acid Derivatives. Organic & Biomolecular Chemistry, in press. 2023. 22. 3. 411-428
Jumpei Maki, Yusuke Hanaki, Ryo C Yanagita, Masayuki Kikumori, Anastasiia Kovba, Ayaka Washizaki, Chihiro Tsukano, Hirofumi Akari, Kazuhiro Irie. Biological evaluation of a phosphate ester prodrug of 10-methyl-aplog-1, a simplified analogue of aplysiatoxin, as a possible latency-reversing agent for HIV reactivation. Bioscience, Biotechnology, and Biochemistry. 2023. 87. 12. 1453-1461
Hidetaka Kuroiwa, Soichiro Suzuki, Kazuhiro Irie, Chihiro Tsukano. Total Synthesis and Structure Revision of (+)-Lancilactone C. Journal of the American Chemical Society. 2023. 145. 27. 14587-14591
Ryotaro Yagita, Kazuhiro Irie, Chihiro Tsukano. Toward the Total Synthesis of Schinortriterpenoids: Construction of the all-cis-substituted cyclopropane unit. Synlett. 2023

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MISC (219)：

Saori KITA, Kazuhiro IRIE, Chihiro TSUKANO. Synthetic Studies on the Right and Left-Hand Fragments of Epoxyboetirane A, a Lathyrane-Type Diterpene. 2024. 2024
Ayumi UCHINO, Chihiro TSUKANO, Kazuhiro IRIE. Synthetic study on the C3-symmetric tris-amino acid linker for the trimer models of amyloid β peptides. 2024. 2024
塚野千尋. アロタケタール類の単純化アナログの設計、立体異性体の系統的合成とPKC結合活性. 日本薬学会年会要旨集 144th. 2024. 2024
塚野千尋. アロタケタール類の単純化アナログの設計、立体異性体の系統的合成とPKC結合活性. 日本農芸化学会大会講演要旨集(Web). 2024. 2024
Chihiro Tsukano, Hidetaka Kuroiwa, Soichiro Suzuki, Kazuhiro Irie. Total Synthesis and Structure Revision of (+)-Lancilactone C. IKCOC-15. 2023

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Patents (2)：

アルツハイマー病予防薬
ポリ環状エーテル化合物とギムノシン-Aの合成方法

Books (4)：

Asymmetric Dearomatization Reactions
Wiley-VCH 2016 ISBN:9783527338511
多環性アルカロイドからの新規抗癌剤シード化合物創製、遺伝子医学MOOK20, ナノバイオ技術と最新創薬応用研究p66-71
メディカルドゥ 2012
(+)-Gymnocin-A
有機化学合成協会編(共著),化学同人,2009,p.85-88. 2009
巨大ポリエーテル天然物・ギムノシン-Aの全合成, 天然物全合成の最新動向
シーエムシー出版, 2009, p228-243. 2009

Education (4)：

2003 - 2006 Tohoku University Graduate School of Life Sciences Department of Biomolecular Sciences
2001 - 2003 The University of Tokyo Graduate School of Science Department of Chemistry
1999 - 2001 The University of Tokyo Faculty of Science Department of Chemistry
1997 - 1999 The University of Tokyo College of Arts and Sciences

Professional career (1)：

Life Sciences (Tohoku University)

Work history (7)：

2024/04 - 現在 Kyoto University Graduate School of Agriculture Division of Food Science and Biotechnology Professor
2019/04 - 2024/03 Kyoto University Graduate School of Agriculture Division of Food Science and Biotechnology Assistant Professor,Assistant Professor
2014/04 - 2019/03 Kyoto University Graduate School of Pharmaceutical Sciences Division of Physical and Organic Chemistry Lecturer
2009/06 - 2014/03 Kyoto University Graduate School of Pharmaceutical Sciences Division of Physical and Organic Chemistry Assistant Professor
2008/07 - 2009/05 Tohoku University Graduate School of Science Department of Chemistry Assistant Professor

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Awards (8)：

2022/07 - Bulletin of the Chemical Society of Japan BCSJ Award Article
2017/12 - Chemist Award BCA 2017
2017/11 - Thieme Thieme Chemistry Journals Award
2016/10 - Asian Core Program/ Advanced Research Network Lectureship Award
2016/03 - 日本薬学会奨励賞

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Association Membership(s) (5)：

The Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA) , The Parmaceutical Society of Japan , American Chemical Society , The Society of Synthetic Organic Chemistry, Japan , The Chemical Society of Japan

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