
	Chemical structure search How to Search	Import MOLfile format is only available (V3000 format is not available) Exact match Substructure search Superstructure search Substructure or superstructure search Similarity search

Rchr

J-GLOBAL ID：200901092573853300 Update date: Jan. 28, 2025

OYAMA Fumitaka

オヤマフミタカ | OYAMA Fumitaka

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.ns.kogakuin.ac.jp/~wwa1074/index.html

Research field (6)： Laboratory animal science , Neuroanatomy and physiology , Pathobiochemistry , Biochemistry , Applied biochemistry , Genetics

Research keywords (14)： gene expression in cancerous tissues , Huntington disease , Alzheimer's disease , Enzyme strucutr-function relationship , Chitin・chitosan , allergy and asthma , Disease-related genes , ほ乳類キチナーゼ , キチン含有生物の動物食糧への利用 , キチン・キトサン , ヒトの疾患に関係する遺伝子 , firefly luciferase , Enzyme strucutr-function relationship , allergy and asthma

Research theme for competitive and other funds (27)：

2023 - 2026 Evolution of structure and function of acid chitinase (Chia): Promoting its use in livestock feed for insects
2016 - 2019 Is acidic mammalian chitinase a major glycosidase in the stomachs of mouse and porcine?
2009 - 2019 Studies on the structure and function relationships of proteins using the biotechnological methods
2009 - 2019 Application of animal biomass for medical and pharmacological areas
2009 - 2019 Development of novel methods for isolation and characterization of cells and nucleic acids

Show all

Papers (60)：

Kazuaki Okawa, Masashi Kijima, Mana Ishii, Nanako Maeda, Yudai Yasumura, Masayoshi Sakaguchi, Masahiro Kimura, Maiko Uehara, Eri Tabata, Peter O. Bauer, et al. Hyperactivation of human acidic chitinase (Chia) for potential medical use. Journal of Biological Chemistry. 2025. 301. 1. 108100-108100
Kazuaki Okawa, Masashi Kijima, Mana Ishii, Nanako Maeda, Yudai Yasumura, Masayoshi Sakaguchi, Masahiro Kimura, Maiko Uehara, Eri Tabata, Peter O. Bauer, et al. Hyperactivation of human acidic chitinase (Chia) for potential medical use. Journal of Biological Chemistry. 2025. 301. 1. 108100-108100
Keita Suzuki, Hidetoshi Suzuki, Ami Tanaka, Miwa Tanaka, Kairi Takase, Hiromu Takei, Tomoki Kanaizumi, Kazuaki Okawa, Peter O. Bauer, Fumitaka Oyama. A Simplified Method for Evaluating Chitin-Binding Activity Applied to YKL-40 (HC-gp39, CHI3L1) and Chitotriosidase. Molecules. 2024
Suzuki K, Okawa K, Ohkura M, Kanaizumi T, Kobayashi T, Takahashi K, Takei H, Otsuka M, Tabata E, Peter O. Bauer, et al. Evolutionary insights into sequence modifications governing chitin recognition and chitinase inactivity in YKL-40 (HC-gp39, CHI3L1). The Journal of biological chemistry. 2024. in press
Tabata E, Kobayashi I, Morikawa T, Kashimura A, Bauer PO, Oyama F. Evolutionary activation of acidic chitinase in herbivores through the H128R mutation in ruminant livestock. iScience. 2023. 26. 107254

ｍore...

MISC (106)：

Haruko Miyazaki, Tomoyuki Yamanaka, Fumitaka Oyama, Yoshihiro Kino, Masaru Kurosawa, Mizuki Yamada-Kurosawa, Risa Yamano, Tomomi Shimogori, Nobutaka Hattori, Nobuyuki Nukina. FACS-array-based cell purification yields a specific transcriptome of striatal medium spiny neurons in a murine Huntington disease model. Journal of Biological Chemistry. 2020. 295. 29. 9768-9785
田畑絵理, 田畑絵理, 樫村明徳, 上原麻衣子, 脇田悟誌, 菅原康里, 圦本晃海, 佐々木えりか, 小山文隆. Gene expression analysis and enzyme function of acidic chitinase in common marmoset. 日本農芸化学会大会講演要旨集(Web). 2020. 2020
大野美紗, 宮崎雅雄, 木村将大, 坂口政吉, 小山文隆, 山下哲郎. マウスにおけるジ-N-アセチルキトビアーゼの発現解析と酵素の性質解析. 日本生化学会大会プログラム・講演要旨集. 2019. 92回. [2T17a-03]
田畑絵理, 田畑絵理, 樫村明徳, 上原麻衣子, 脇田悟誌, 菅原康里, 圦本晃海, 佐々木えりか, 小山文隆. Common marmoset (Callithrix jacchus), an insectivorous nonhuman primate, predominantly expresses acidic chitinase, which can digest insect chitin in stomach. キチン・キトサン研究. 2019. 25. 2
Masayoshi Sakaguchi, Yudai Matsushima, Toshiyuki Nankumo, Junichi Seino, Satoshi Miyakawa, Shotaro Honda, Yasusato Sugahara, Fumitaka Oyama, Masao Kawakita. Glucoamylase of Caulobacter crescentus CB15: cloning and expression in Escherichia coli and functional identification. AMB EXPRESS. 2014. 4. 5

ｍore...

Patents (1)：

アルツハイマー病モデル動物

Books (17)：

ß -アミロイドと PHF 広川ニューロサイエンス 3 新しい神経伝達研究法 II 2. 生化学的研究法 2.2. 細胞膜、物質レベルの研究
広川書店 2000
タウの分解機構
Dementia Japan 日本認知症学会 1999
Update article: Chloroquine myopathy suggests that tau is degraded in lysosomes : implication for the formation of paired helical filaments in Alzheimer’s disease.
Neurosci. Res. Elsevier 1998
Nonneural tau: transient upregulation and subsequent accumulation of big and small tau in chloroquine myopathy.
In Alzheimer's Disease: Biology, Diagnosis and Therapeutics (ed. by Iqbal et al.) 1997
クロロキンミオパチーラット
内科 1996

ｍore...

Lectures and oral presentations (220)：

Enhancing the activity of YKL-39: investigating mutations and enzymatic properties
(Annual Meeting of the American Society of Human Genetics (ASHG) 2024)
Engineering chimeric and mutant chitinase proteins to uncover the underlying mechanisms of decreased acidic chitinase activity in herbivorous animals
(Engineering recombinant proteins for structural and functional studies 2023 2023)
Multiple sequence modifications result in loss of chitinolytic activity in YKL-40.
(Annual Meeting of the American Society of Human Genetics (ASHG) 2023)
Structure and function of mammalian chitinases: Insights from chimeric analysis
(Annual Meeting of the American Society of Human Genetics (ASHG) 2023)
反芻動物の酸性キチナーゼの活性化
(第37回日本キチン・キトサン学会大会 2023)

ｍore...

Works (5)：

Characterization of crab-eating monkey acidic chitinase: Robust chitinolytic activity and its application
Maiko Uehara and Fumitaka Oyama 2022 - 2022
Tau dynamics in chloroquine myopathy suggests that tau is degraded in lysosomes in muscle」
Fumitaka Oyama, Nobuyuki Murakami, Yongjun Gu, Ikuya Nonaka, and Yasuo Ihara 1997 - 1997
非神経系の tau の動態:アルツハイマー病モデルとしてのクロロキンミオパチーでの解析
小山文隆、顧擁軍、村上信行、埜中征哉、井原康夫 1996 - 1996
Alternative Splicing of fibronectin pre-mRNA in Human Tissues
Fumitaka Oyama 1992 - 1992
逆転写酵素の DNA-polymerase 活性とRNase H 活性の逆転写過程における作用機作
小山文隆 1992 - 1992

Education (3)：

1982 - 1985 Tohoku University Graduate School of Agricultural Science Agricultural Chemistry Program
1980 - 1982 Tohoku University Graduate School of Agricultural Science Agricultural Chemistry Program
1976 - 1980 Ibaraki University Faculty of Agriculture Department of Agricultural Chemistry

Professional career (3)：

BS (Ibaraki University)
M.S. (Agricultural Chemistry) (Tohoku University)
Ph.D. (Agricultural Chemistry) (Tohoku University)

Work history (10)：

2015/04 - 現在 Kogakuin University School of Advanced Engineering, Department of Chemistry and Life Science
2019/04 - 2020/03 京都大学霊長類研究所非常勤講師
2009 - 2015/03 Kogakuin University Faculty of Engineering, Department of Applied Chemistry
2012/04 - 工学院大学大学院工学研究科博士後期課程化学応用学専攻担当
2009/04 - 2012/03 Visiting Research Scientist, Laboratory for Structural Neuropathology, RIKEN Brain Science Institute

Show all

Committee career (5)：

2018/08 - 2019/08 Board member the Japanese Society for Chitin and Chitosan
2014/01 - 2016/08 Japanese Society for Chitin and Chitosan Board of directors
2014/01 - 2014/12 Board of directors, the Japanese Society for Chitin and Chitosan
2011/01 - 2013/12 Japanese Society for Chitin and Chitosan Board member
2011/01 - 2013/12 Board of the Japanese Society for Chitin and Chitosan

Association Membership(s) (5)：

Japanese Society for Chitin and Chitosan , American Society of Human Genetics , JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY , American Society of Human Genetics , Japanese Society for Chitin and Chitosan

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page


	Free word	※Add the following synonyms, you can increase the number of hits.




		～