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J-GLOBAL ID：200901093244587638 Update date: Mar. 17, 2025

Hemmi Hisashi

ヘンミヒサシ | Hemmi Hisashi

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Affiliation and department：
Job title： Associate professor
Homepage URL (1)： http://www.agr.nagoya-u.ac.jp/~bmm/hemmi/index.html

Research field (1)： Applied microbiology

Research keywords (5)： molecular evolution , lipid , enzyme , isoprenoid , archaea

Research theme for competitive and other funds (12)：

2020 - 2023 Creation of microbial cells as the innovative chassis for isoprenoid production
2019 - 2021 「緩い」基質認識が可能にするプレニル基転移反応のリデザイン
2018 - 2020 超好熱性古細菌膜脂質を使った大腸菌の細胞膜エンジニアリング
2017 - 2019 イソプレノイドの構造多様性を生み出すイソプレン単位間縮合反応のマシナリー
2016 - 2018 アーキア膜脂質の生産によるバクテリア細胞膜強化の試み

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Papers (114)：

Ryo Yoshida, Kento Motoyama, Tomokazu Ito, Hisashi Hemmi. Effects of producing high levels of hyperthermophile-specific C25,C25-archaeal membrane lipids in Escherichia coli. Biochemical and Biophysical Research Communications. 2024. 729
Hinano Matsuo, Naoki Yamada, Hisashi Hemmi, Tomokazu Ito. Identification of YigL as a PLP/PNP phosphatase in Escherichia coli. Applied and Environmental Microbiology. 2024. 90. 9
Kosuke Kanno, Riko Kuriki, Yoko Yasuno, Tetsuro Shinada, Tomokazu Ito, Hisashi Hemmi. Archaeal mevalonate pathway in the uncultured bacterium Candidatus Promineifilum breve belonging to the phylum Chloroflexota. Applied and Environmental Microbiology. 2024. 90. 8
Tomokazu Ito, Natsumi Muto, Haruna Sakagami, Miho Tanaka, Hisashi Hemmi, Tohru Yoshimura. d-amino acid auxotrophic Escherichia coli strain for in vivo functional cloning of novel d-amino acid synthetic enzyme. FEBS Journal. 2023. 290. 11. 2895-2908
Mutsumi Komeyama, Kohsuke Kanno, Hiroyuki Mino, Yoko Yasuno, Tetsuro Shinada, Tomokazu Ito, Hisashi Hemmi. A [4Fe-4S] cluster resides at the active center of phosphomevalonate dehydratase, a key enzyme in the archaeal modified mevalonate pathway. Frontiers in microbiology. 2023. 14. 1150353-1150353

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MISC (81)：

Discovery of the archaeal mevalonate pathway. 2021. 93. 2. 221-224
米山睦, 三野広幸, 保野陽子, 品田哲郎, 吉村徹, 邊見久. Analysis of the iron-sulfur cluster present in the active center of mevalonate phosphate dehydratase from hyperthermophilic archaea. 日本農芸化学会大会講演要旨集(Web). 2021. 2021
松嶋夏海, 栗木莉子, 保野陽子, 品田哲郎, 吉村徹, 邊見久. Enzymatic study of trans-anhydromevalonate phosphate decarboxylase, a key enzyme of the archaeal mevalonate pathway. 日本農芸化学会大会講演要旨集(Web). 2021. 2021
米山睦, 三野広幸, 保野陽子, 品田哲郎, 伊藤智和, 邊見久. アーキア型メバロン酸経路の鍵酵素であるホスホメバロン酸脱水酵素は[4Fe-4S]型鉄硫黄クラスターを有する. 日本Archaea研究会講演会要旨集. 2021. 33rd (CD-ROM)
米山睦, 齋藤甲斐, 保野陽子, 品田哲郎, 吉村徹, 邊見久. Characterization of phosphomevalonate dehydratase involved in the archaeal mevalonate pathway. 日本農芸化学会大会講演要旨集(Web). 2020. 2020

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Patents (7)：

新規メバロン酸経路を有する非古細菌生物
新規な亜鉛吸着菌及び該菌を用いた亜鉛を除去・回収する方法
Long-chain prenyl diphosphate synthase
Process for the production of prenyl diphosphate using mutants of geranylgeranyl diphosphate synthase
Nucleic acid encoding mutant geranylgeranyl diphosphate synthase

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Books (5)：

ビタミン・バイオファクター総合事典
朝倉書店 2021 ISBN:9784254102925
生体膜の分子機構:リピッドワールドが先導する生命科学
化学同人 2014
Handbook of Flavoproteins
Walter de Gruyter 2012
Comprehensive Natural Products II Chemistry and Biology
Elsevier 2010
酵素ハンドブック第3版
朝倉書店 2008

Lectures and oral presentations (64)：

アーキア型メバロン酸経路の鍵酵素であるホスホメバロン酸脱水酵素は[4Fe-4S]型鉄硫黄クラスターを有する
(第33回日本Archaea研究会講演会 2021)
未培養真正細菌に存在する古細菌型メバロン酸経路
(第30回イソプレノイド研究会例会 2020)
超好熱性アーキアAeropyrum pernix由来ホスホ-trans-アンヒドロメバロン酸デカルボキシラーゼの特性評価
(第20回極限環境生物学会年会 2019)
Discovery of a “fourth” mevalonate pathway from the hyperthermophilic archaeon Aeropyrum pernix
(Thermophiles 2019 15th International Congress on Thermophiles 2019)
超好熱アーキアに見出した「第4の」メバロン酸経路
(シンポジウム「好熱菌研究最前線」in微生物ウィーク2019 2019)

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Education (2)：

1993 - 1998 Tohoku University Graduate School of Engineering
1989 - 1993 Tohoku University Faculty of Engineering

Professional career (1)：

Doctor of Engineering (Tohoku University)

Work history (5)：

2022/05 - 現在 Nagoya University Graduate School of Bioagricultural Sciences Department of Applied Biosciences Professor
2007/04 - 2022/04 Nagoya University Graduate School of Bioagricultural Sciences Department of Applied Molecular Biosciences Associate professor
2005/08/01 - 2007/03/31 Associate Professor, Graduate School of Bioagricultural Sciences, Nagoya University
1998/04/01 - 2005/07/31 Research Associate, Graduate School of Engineering, Tohoku University
2004/09 - 2005/06 Visiting scientist, University of Nebraska-Lincoln, USA

Committee career (18)：

2013/11 - 現在日本ビタミン学会代議員
2020/06 - 2024/05 日本農芸化学会代議員
2023/09 - 第75回日本生物工学会大会実行委員会委員
2018/03 - 日本農芸化学会2018年度大会実行委員会委員
2013/04 - 2015/03 日本農芸化学会中部支部庶務幹事

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Awards (3)：

2019/04 - 長瀬研究振興賞
2010/06 - The Vitamin Society of Japan Young Scientist Award
2009/06 - 天野エンザイム酵素応用シンポジウム研究奨励賞

Association Membership(s) (9)：

American Society for Biochemistry and Molecular Biology , American Society for Microbiology , 日本Archaea研究会 , イソプレノイド研究会 , The Japanese Biochemical Society , The Vitamin Society of Japan , The Society for Biotechnology, Japan , Japan Society for Bioscience, Biotechnology, and Agrochemistry , 極限環境生物学会

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