2021 - 2024 Patient specific assessment of hemodynamics by computational fluid dynamics in patients with acute non-A non-B aortic dissection
2020 - 2023 Influence of shear stress on human aortic endothelial cell/smooth muscle cell interaction in bicuspid aortic valve aortopathy
2018 - 2021 Study on the role of the mechanical dynamics in the nucleus in cellular mechanical responses
2018 - 2021 数値流体力学計算に基づく慢性大動脈解離における大動脈拡大機序の解明
2018 - 2020 Verification of local translational mechanism contributing to polarized cellular mechano-responses
2017 - 2020 Study on the effects of the mechanical environment of the cell nucleus on the radiation resistance of cells
2016 - 2018 The involvement of cell polarity in trabecular formation
2015 - 2018 Study of the role of nuclear mechanical remodeling in cellular mechano-responses
2014 - 2017 Elucidation of signal transduction mechanism in endothelial cells under high shear flow with spatio-temporal changes
2011 - 2012 STUDY ON ROLE OF INTRACELLULAR FORCE TRANSMISSION VIA LINC COMPLEX IN CELL RESPONSES
2010 - 2012 Regulation mechanisms of mechanostress-induced actin cytoskeleton reorganzation
2008 - 2012 Study of Mechanisms of Cellular Mechanosensing
2009 - 2010 Fundamental Study for Development of An Engineering Model of Remodeling Mechanism of Blood Vessel Walls in Response to Mechanical Environment
2008 - 2010 Development of Bioassay System with Microwell Slide Towards High throughput Single Cell Analysis
2008 - 2008 磁気駆動マイクロピラーによる細胞外局所力学環境のアクティブ操作
2007 - 2008 細胞内シグナル伝達の動的制御による細胞マイクロマシンの創出
2006 - 2008 マイクロポストを用いた細胞の形態制御と力学伝達経路の解明
2006 - 2007 マトリックスデバイスによる細胞骨格の力学バランス計測と細胞機能制御
2005 - 2007 Study of roles of cytoskeletons in morphological responses of vascular endothelial cells to mechanical stimuli
2005 - 2006 細胞内ストレスファイバの力学特性計測と変形機構の解明
2003 - 2006 Mechanical dynamics of focal adhesions of vascular endothelial cells using nano-imaging
2003 - 2004 Study of the Effect of Hemodynamic Forces on Mechanism of Atherogenesis using Cocultured Blood Vessel Model
2003 - 2004 ナノマシン加工技術による内皮細胞焦点接触力の計測デバイスの開発
2002 - 2004 Roles of Integrins of Endothelial Cells in Response to Mechanical Stimuli
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Papers (4)：
Kaoru Sawasaki, Masanori Nakamura, Naoyuki Kimura, Koji Kawahito, Masashi Yamazaki, Hiromichi Fujie, Naoya Sakamoto. Endothelial-derived nitric oxide impacts vascular smooth muscle cell phenotypes under high wall shear stress condition. Biochemical and Biophysical Research Communications. 2024
Bo-Jiang Lin, Hiromichi Fujie, Masashi Yamazaki, Naoya Sakamoto. The Dual Effect of Fiber Density and Matrix Stiffness on A549 Tumor Multicellular Migration. Biochemical and Biophysical Research Communications. 2024
Kaoru Sawasaki, Yuta Horie, Masanori Nakamura, Naoyuki Kimura, Koji Kawahito, Naoya Sakamoto. Effect of mechanical environment caused by impinging jet flow on vascular endothelial cells. Transactions of Japanese Society for Medical and Biological Engineering. 2020. 58. 574-575
Toshiro Ohashi, Shouji Nakamura, Naoya Sakamoto, Masaaki Sato. Estimation of mechanical role of intracellular structures in smooth muscle cells by using traction force measurements. Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007. 2007. 134-136
MISC (250)：
Takashi Miyano, Atsushi Suzuki, Naoya Sakamoto. Actin cytoskeletal reorganization is involved in hyperosmotic stress-induced autophagy in tubular epithelial cells. Biochemical and Biophysical Research Communications. 2023
Makoto Ohta, Naoya Sakamoto, Kenichi Funamoto, Zi Wang, Yukiko Kojima, Hitomi Anzai. A Review of Functional Analysis of Endothelial Cells in Flow Chambers. JOURNAL OF FUNCTIONAL BIOMATERIALS. 2022. 13. 3
Takashi Miyano, Atsushi Suzuki, Naoya Sakamoto. Calcium influx through TRPV4 channels involve in hyperosmotic stress-induced epithelial-mesenchymal transition in tubular epithelial cells. Biochemical and Biophysical Research Communications. 2022
Yuya Hiroshima, Yuki Oyama, Kaoru Sawasaki, Masanori Nakamura, Naoyuki Kimura, Koji Kawahito, Hiromichi Fujie, Naoya Sakamoto. A Compressed Collagen Construct for Studying Endothelial-Smooth Muscle Cell Interaction Under High Shear Stress. Annals of biomedical engineering. 2022. 50. 8. 951-963
Shingo Tsukamoto, Keng-Hwee Chiam, Takumi Asakawa, Kaoru Sawasaki, Naoyuki Takesue, Naoya Sakamoto. Compressive forces driven by lateral actin fibers are a key to the nuclear deformation under uniaxial cell-substrate stretching. Biochemical and Biophysical Research Communications. 2022. 597. 37-43
Morphological changes in cultured endothelial cells exposed to high shear stress and high shear stress gradient
(MIT-NUS-NTU-Tohoku University Global COE Joint Workshop on Micro & Nano Bioengineering 2010)
Effect of Spatial Gradient of Shear Stress on Morphological Responses of Endothelial Cells to Flow
(The 6th World Congress on Biomechanics 2010)
Effect of cyclic stretch on production of inflammatory cytokines from macrophages
(The 6th World Congress on Biomechanics 2010)
yrosine Phosphorylation of Endothelial Cell-Cell Adhesion Proteins Induced by Shear Stress Gradient
(BMES Annual Meeting 2010 2010)
Sorting of microtubules by length using micro-grooves fabricated on a chip
(BMES Annual Meeting 2010 2010)
- 2003 Tohoku University Graduate School, Division of Engineering Department of Mechatronics andPrecision Engineering
- 2000 Tohoku University Faculty of Engineering
- 2000 Tohoku University Faculty of Engineering Department of Mechatronics and Precision Engineering
- 1997 National Institute of Technology, Matsue College
- 1997 Matsue National College of Technology Faculty of Engineering Department of Control Engineering
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Professional career (1)：
博士(工学) (東北大学)
Work history (4)：
2020/04 - 現在 Tokyo Metropolitan University Department of Mechanical Systems Engineering Associate Professor
2015/04 - 2019/03 Tokyo Metropolitan University Graduate School of Systems Design Associate Professor
2012/04 - 2015/03 Kawasaki University of Medical Welfare Department of Medical Engineering Associate Professor
2003/04 - 2012/03 Tohoku University Graduate School of Engineering Department of Bioengineering and Robotics, Biomechanics,Cell Biomechanics Assistant Professor
Committee career (2)：
2010 - 日本バイオレオロジー学会 編集委員
2010 - 日本バイオレオロジー学会 編集委員
Awards (4)：
2008 - 第13回研究奨励賞
2008 - 日本機械学会奨励賞
2008 - 第13回研究奨励賞
2008 - 日本機械学会奨励賞
Association Membership(s) (8)：
日本バイオレオロジー学会
, 日本生体医工学会
, 日本機械学会
, 日本バイオレオロジー学会
, Japanese Society of Biorheology
, Japanese Society for Medical and Biological Engineering
, The Japan Society of Mechanical Engineers
, Biomedical Engineering Society (BMES)
