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J-GLOBAL ID：200901094411515306 Update date: Mar. 27, 2025

Yamamoto Yuhei

ヤマモトユウヘイ | Yamamoto Yuhei

Affiliation and department：
Job title： Professor

Research field (1)： Plastic and reconstructive surgery

Research keywords (26)：制御性T細胞 , ケロイド , 軸索再生 , 末梢神経 , リンパ節郭清 , リンパ節転移 , 遠隔転移 , リンパ系再構築 , リンパ系機能不全 , 転移 , 免疫系 , 組織培養・移植学 , リンパ組織再構築 , 放射線照射 , 羊膜 , 再生医療 , 脂肪移植 , 間葉系幹細胞 , fibroblast , 悪性黒色腫 , ケモカイン , myofibroblast , fibrocyte , keloid , 形成外科 , Plastic and Reconstructive Surgery

Research theme for competitive and other funds (53)：

2024 - 2027 幹細胞によるM1/M2マクロファージ調整作用はリンパ浮腫線維化を抑制しうるか?
2023 - 2026 Effects of negative pressure wound therapy on the hair cycle and hair growth
2023 - 2026 SASP Regulation of Photoaging - Skin Rejuvenation by Stem Cell Exosomes
2023 - 2026 Genetic diagnosis of vascular malformations by liquid biopsy and its application to precision medicine
2020 - 2023 低酸素応答システム活性化薬剤を用いた下肢慢性創傷の新治療

2020 - 2023 低酸素応答システムからケロイド病態を斬る!~局所免疫の正常化と炎症・線維化の抑制

2019 - 2022 Potential abilities of visceral fat:circulation and immunity (hyper 2-way player)

2018 - 2021 The Study on Promotion the Survival of Fat Grafts by Amnion-Derived Mesenchymal Stem Cells

2017 - 2020 下肢慢性創傷の治癒促進に向けた低酸素応答システム制御の試み

2016 - 2019 Development of functional lymph node transfer

2015 - 2018 The surgical lymphatic regeneration for improving the prognosis of melanoma

2014 - 2017 Investigation of the anti inflammatory and antifibrotic function of regulatory T cells to establish the immune cell therapy in keloid

2014 - 2017 Elucidation of the pathology of lymphedema and search for effective lymphangiogenesis

2014 - 2016 Neurotization through the venous network in muscle : intravenous migration of Schwann cells.

2013 - 2016 Elucidating the collapse of immune system against malignant melanoma

2013 - 2015 Effect of immunosuppressive agents on the interaction between keloid fibroblasts and CD4+ T cells in a coculture model

2013 - 2015 The efficiency of side-to-side neurorrhaphy : the condition of donor nerve effects neural recovery.

2012 - 2015 Imaging of lymph flow in mouse model using in vivo imaging system

2012 - 2014 Mechanism of the improvement of lymphedema with the lymph node transfer

2012 - 2014 Active axonal guidance for reconstruction of facial palsy

2012 - 2014 Effects of estrogen and selective estrogen receptor modulators on normal and keloid fibroblasts

2011 - 2014 Lymph node targeting by human interferon-ß with hyaluronic acid based on metal coordination

2011 - 2013 A New Perspective Of Therapies For Keloids: Application Of An Antifibrotic Medicine

2011 - 2013 Controlled release of granulocyte colony-stimulating factor (G-CSF) enhances osteoconductive and biodegradable properties of beta-tricalcium phosphate (beta-TCP) in a rat calvarial defect model

2011 - 2012 Does HGF act as a inhibitor of TGF-β mediated keloid formation?

2010 - 2012 Clarifying the metastatic mechanisms of melanoma by imaging techniques

2010 - 2012 Dynamic change of Myogenin in denervated rat mimetic muscle: Does the neural repair repress its expression ?

2010 - 2012 The role of circulating fibrocytes in keloid diathesis.

2008 - 2010 Can we detect the invasive keloid fibroblasts for the effective treatment?

2008 - 2010 The influence of interactions between normal lymphatic endothelial cells and melanoma cells on cell migration

2007 - 2009 New lymphatic imaging with indocyanine green (ICG) dye labeled hyaluronic acid derivative

2008 - 2008 創傷由来の血管内皮前駆細胞・周皮前駆細胞を用いた動脈・静脈への分化誘導

2007 - 2008 Verification of Neural-supercharge technique for incomplete facialpalsy

2007 - 2008 カーボンナノホーンをキャリアとする創傷に対するドラッグデリバリーシステムの開発

2006 - 2008 Development of novel therapy for malignant melanoma by morphogenetic gene transfer

2006 - 2007 リンパ管内皮細胞を標的とした再生治療〜不死化細胞樹立と機能するリンパ網の作成〜

2006 - 2006 各種神経疾患に対する支配神経信号の増幅を目指したネットワーク型神経再建法の開発

2005 - 2006 新しいケロイド治療薬としてのcAMP製剤の可能性

2004 - 2005 A new treatment approach for Malignant Melanoma basing on analysis of expression pattern of homeobox genes

2004 - 2005 Novel gene therapy of keloid by using siRNA

2004 - 2005 Novel Strategy for Treatment of Keloid ; Application of siRNA and Keratinocyte

2004 - 2005 進行期悪性黒色腫に対する治療の個別化を目指して-抗癌剤耐性関連遺伝子の発現解析-

2004 - 2004 毛髪再生医療戦略-HOX遺伝子からのアプローチ-

2002 - 2003 Strategic treatment by means of transduction of gene in Malignant Melanoma

2002 - 2003 遺伝子導入表皮角化細胞を介したケロイド発生制御機構の解明とその臨床応用

2001 - 2003 Analysis of Master Genes Associated with Invasion and Metastasis by Malignant Melanoma

2001 - 2002 Analysis of MIF function in wound healing using transgenic mouse

2001 - 2002 メラノーマ関連遺伝子を用いたメラノーマ微小転移検出法の開発

1999 - 2000 Gene transfection in human keratinocyte and melanocyte

1997 - 1999 放射線障害における血管内皮由来弛緩因子(NO)の作用に関する基礎的研究

Basic and clinical research of skin cancer

Clinical study of functional and aesthetic reconstructive surgery

Functional evaluation of arterial, venous, and lymphatic vessel

Show all

Papers (431)：

Matsuda N, Sato C, Ishikawa K, Miura T, Funayama E, Yamamoto Y, Fuyama K, Ohnishi S, Maeda T. A novel mouse model for studies of burn wound conversion using a top hat-shaped brass template. Burns. 2025. 51. 2. 107348
Dongkyung Seo, Riri Ito, Kosuke Ishikawa, Takahiro Miura, Yuhei Yamamoto, Yasuhito Onodera, Soichiro Nishioka, Yoichi M. Ito, Kanako Fuyama, Taku Maeda. 3D scanner’s potential as a novel tool for lymphedema measurement in mouse hindlimb models. Scientific Reports. 2025. 15. 1
Kosuke Ishikawa, Yoshitada Hoshino, Masayuki Osawa, Emi Funayama, Takahiro Miura, Masahiro Hojo, Yuki Sasaki, Satoru Sasaki, Yuhei Yamamoto, Taku Maeda. Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat Accelerates Wound Healing in a Mouse Hind limb Lymphedema Model. Advances in wound care. 2025
Sasaki Y., Maeda T., Hojo M., Miura T., Ishikawa K., Funayama E., Okada K., Yamamoto Y. Synergistic anti-tumor effects of oncolytic virus and anti-programmed cell death protein 1 antibody combination therapy: For suppression of lymph node and distant metastasis in a murine melanoma model. Biochemical and Biophysical Research Communications. 2024. 740. 151011
Taku Maeda, Kosuke Ishikawa, Toshihiko Hayashi, Hiroshi Furukawa, Takahiro Miura, Masahiro Hojo, Emi Funayama, Yuhei Yamamoto. Comparison of leg volume ratio between inguinal lymphadenectomy and inguino-pelvic lymphadenectomy in patients with skin cancer of the lower extremity. Journal of Plastic, Reconstructive & Aesthetic Surgery. 2024. 99. 397-405

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MISC (171)：

Toshihiko Hayashi, Taku Maeda, Yuhei Yamamoto, Emi Funayama. New Design Concept of Nasolabial Flap for the Reconstruction of a Complex Defect in the Alar Base. Facial Plastic Surgery. 2021. 37. 1. 134-135
村尾尚規, 齋藤達弥, 草島英梨香, 前田拓, 堀内勝己, 松井傑, 山本有平. Indications and Limitations of Negative Pressure Wound Therapy with instillation and Dwell Time. 形成外科. 2019. 62. 10. 1070-1078-1078
小田陽一郎, 小田陽一郎, 古川洋志, 村尾尚規, 高桑恵美, 山本有平. Lipofibromatosis arising in an infantile back : A case report. Skin Cancer (Web). 2019. 33. 3. 250-254(J-STAGE)
古川洋志, 大澤昌之, 小山明彦, 村尾尚規, 林利彦, 舟山恵美, 山本有平. 【顔面神経麻痺の治療アルゴリズム:ベストプラクティス】当教室の顔面神経麻痺に対する外科治療のアルゴリズム. 日本頭蓋顎顔面外科学会誌. 2018. 34. 1. 16-20
杉井政澄, 古川洋志, 七戸龍司, 村尾尚規, 山本有平. Lipoma of the Parotid Gland: A Case Report. 日本頭蓋顎顔面外科学会誌. 2017. 33. 3. 98-102

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Books (20)：

腫瘍・母斑・血管奇形 (形成外科治療手技全書)
克誠堂出版 2018 ISBN:4771905010
Oncoplastic Skin Surgery-私ならこう治す! (PEPARS(ペパーズ))
全日本病院出版会 2013 ISBN:4881175254
Oncoplastic skin surgery : 私ならこう治す!
全日本病院出版会 2013 ISBN:9784881175255
形成外科医に必要な皮膚腫瘍の診断と治療 (形成外科診療プラクティス)
文光堂 2009 ISBN:4830626305
形成外科医に必要な皮膚腫瘍の診断と治療
文光堂 2009 ISBN:9784830626302

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Works (3)：

Expression of a Truncated Gelsolin in Malignant Melanoma
2001 -
endothelial Changes Following Irradiation
1997 -
Development of Laserflowgraphy
1993 -

Education (3)：

1991 - 1995 Hokkaido University
1978 - 1984 Hokkaido University School of Medicine
- 1984 Hokkaido University Faculty of Medicine

Professional career (1)：

M.D.,Ph.D. (Hokkaido University)

Work history (2)：

2005/04 - 現在北海道大学医学研究院形成外科学教室教授
2003/10 - 2005/03 北海道大学医学研究科形成外科学分野助教授

Committee career (5)：

2018/07 - 現在日本創傷外科学会理事長
2017/11 - 現在日本頭蓋顎顔面外科理事長
2007/05 - 現在日本皮膚悪性腫瘍学会理事
- 現在日本形成外科学会評議員
2016/10 - 2018/09 日本乳房オンコプラスティックサージャリー学会評議員

Awards (2)：

2000 - 日本形成外科学会臨床研究部門学術奨励賞
1997 - American association for Pediatric Plastic Surgeons Poster Award

Association Membership(s) (17)：

JAPAN SOCIETY OF FACIAL NERVE RESEARCH , 日本抗加齢学会 , 日本頭蓋底外科学会 , 日本下肢救済足病学会 , JAPANESE SOCIETY OF PRESSURE ULCERS , JAPAN SOCIETY FOR HEAD AND NECK CANCER , 日本乳房オンコプラスティックササージャリー学会 , JAPAN SOCIETY OF CRANIO-MAXILLO-FACIAL SURGERY , JAPAN SOCIETY OF AESTHETIC PLASTIC SURGERY , 日本皮膚悪性腫瘍学会 , 日本創傷外科学会 , 日本形成外科手術手技学会 , 日本頭頚部腫瘍学会 , 米国形成再建外科学会 , 国際マイクロサ-ジャリ-学会 , 日本形成外科学会 , 日本マイクロサージャリー学会

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