Kohda Daisuke

Affiliation and department：
Job title： Professor
Other affiliations (1)：

Kyushu University Graduate School of Systems Life Sciences Professor

Homepage URL (2)： http://www.bioreg.kyushu-u.ac.jp/vsb/index.html , http://vsb.bmr.kyushu-u.ac.jp/VSB/index.html

Research field (3)： Biophysics , Functional biochemistry , Structural biochemistry

Research keywords (9)： Electron microscopy Single particle analysis , X線結晶解析 , 核磁気共鳴法 , 立体構造 , 構造生物学 , x-ray crystallography , nuclear magnetic resonance , three-dimensional structure , structural biology

Research theme for competitive and other funds (22)：

2021 - 2025 Residue-specific Linear Free Energy Relationship is the physicochemical basis of protein folding
2020 - 2025 Establishment of research base for lipid chemical biology
2019 - 2020 「動的構造生命科学を拓く新発想測定技術」の成果取りまとめを目指した組織活動
2015 - 2019 Support activities aimed at international network formation in the research area of dynamic structural life sciences
2014 - 2019 New measurement techniques for visualizing live protein molecules at work

2014 - 2019 Novel measurement techniques for visualizing 'live' protein molecules at work

2014 - 2018 Structural analysis and functional modification of unusual amino acid-forming enzyme, and the application to peptide engineering

2013 - 2017 Study on the mechanism of motive force generation in chloroplast movement

2011 - 2014 Lantibiotic engineering: peptide engineering approach using the modification enzymes

2009 - 2014 Integrative understanding of biological processes mediated by transient macromolecul ar complexes; New technology for visualizing physiologically metastable states

2003 - 2009 Molecular soft interactions regulating membrane-interface activities in living systems

2006 - 2007 新規DNA結合モチーフ"TTpocket"を有する機能タンパク質の探索

2004 - 2005 21番目のアミノ酸セレノシステインの蛋白質への取込み機構の立体構造基盤の解明と人工システムの構築

2003 - 2005 Structural and functional analyses of the DNA replication machinery called replisome complex

2000 - 2002 Molecular Mechanism and Function of Ubiquitin-like System in Autophagy

1998 - 2001 Protein-protein interaction in intracellular signal transduction

1994 - 1997 Role of three dimensional structure of proteins in signal transduction

1994 - 1994 NMRによるコフィリン・デストリンの立体構造解析と機関相関

1993 - 1994 Elucidation of Molecular Mechanism of Signal Transduction Mediated by Growth Factor-Receptor System

1993 - 1993 SH3(src相同領域3)ドメインのNMRによる立体構造決定と機能部位の同定

1990 - 1991 Structure -Function relationship of Membrane Bound Peptides Using DPC Micelles

1987 - 1988 Molecular Recognition of Antigen Determinant by Monoclonal Antibody Specific to Neurotoxins from Snake Venoms

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Papers (120)：

Honoka Kawamukai, Shumpei Takishita, Kazumi Shimizu, Daisuke Kohda, Koichiro Ishimori, Tomohide Saio. Conformational Distribution of a Multidomain Protein Measured by Single-Pair Small-Angle X-ray Scattering. The Journal of Physical Chemistry Letters. 2024. 15. 3. 744-750
Sam-Geun Kong, Yosuke Yamazaki, Atsushi Shimada, Saku T Kijima, Keiko Hirose, Kaoru Katoh, Jeongsu Ahn, Hyun-Geun Song, Jae-Woo Han, Takeshi Higa, et al. CHLOROPLAST UNUSUAL POSITIONING 1 is a plant-specific actin polymerization factor regulating chloroplast movement. The Plant cell. 2023
Takayuki Obita, Koji Inaka, Daisuke Kohda, Nobuo Maita. Crystal structure of the PX domain of Vps17p from Saccharomyces cerevisiae. Acta Crystallographica Section F Structural Biology Communications. 2022. 78. 5. 210-216
Yuya Taguchi, Takahiro Yamasaki, Marie Ishikawa, Yuki Kawasaki, Ryuji Yukimura, Maki Mitani, Kunio Hirata, Daisuke Kohda. The structure of an archaeal oligosaccharyltransferase provides insight into the strict exclusion of proline from the N-glycosylation sequon. Communications Biology. 2021. 4. 1
Daisuke Fujinami, Hajime Motomura, Hiraku Oshima, Abdullah-Al Mahin, Khaled M Elsayed, Takeshi Zendo, Yuji Sugita, Kenji Sonomoto, Daisuke Kohda. Correction to "Mosaic Cooperativity in Slow Polypeptide Topological Isomerization Revealed by Residue-Specific NMR Thermodynamic Analysis". The journal of physical chemistry letters. 2021. 12. 44. 10766-10767

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MISC (175)：

川崎由貴, 有山弘高, 藤浪大輔, 本村肇, SRIVASTAVA Ashutosh, TAMA Florence, 能代大輔, 安藤敏夫, 真柳浩太, 神田大輔. 統合的なAFM,NMR,電顕単粒子解析により明らかにされたオリゴ糖転移酵素の動的構造. 日本糖質学会年会要旨集. 2019. 38th
Yuya Taguchi, Daisuke Fujinami, Daisuke Kohda. Comparative analysis of the oligosaccharide donors (Lipid-linked oligosaccharides) for the n-oligosaccharyl transfer reaction. Trends in Glycoscience and Glycotechnology. 2018. 30
真柳浩太, 沖啓輔, 石野園子, 宮崎直幸, 岩崎憲治, 神田大輔, 白井剛, 石野良純. クライオ電顕で「見る」古細菌複製フォーク複合体の機能構造. 日本分子生物学会年会プログラム・要旨集(Web). 2018. 41st. ROMBUNNO.3AW-10-5 (WEB ONLY)
真柳浩太, 沖啓輔, 石野園子, 宮崎直幸, 岩崎憲治, 神田大輔, 白井剛, 石野良純. PolD-PCNA-DNA複合体の単粒子解析. 日本生化学会大会(Web). 2017. 90th. ROMBUNNO.2P-0585 (WEB ONLY)-0585]
Hidekazu Hiroaki, Daisuke Kohda. Protein-ligand interactions studied by NMR. Experimental Approaches of NMR Spectroscopy: Methodology and Application to Life Science and Materials Science. 2017. 579-600

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Patents (1)：

「タンパク質の構造座標およびNMR化学シフト並びにそれらの使用

Books (10)：

生化学の論理:物理化学の視点から
2018
Glycobiophysics, Adv Exp Med Biol, Volume 1104
Springer Nature 2018
Experimental approaches of NMR spectroscopy
Springer 2018
アーキア生物学
共立出版 2017
いきなりはじめる構造生物学
学研メディカル秀潤社,学研マーケティング (発売) 2011 ISBN:9784780908428

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Works (1)：

Deposition in the Protein Data Bank

Education (6)：

1981 - 1986 東京大学大学院理学系研究科生物化学専攻
1981 - 1986 The University of Tokyo Graduate School, Division of Science Biochemistry
1979 - 1981 The University of Tokyo Faculty of Science Department of Biophysics and Biochemistry
1979 - 1981 The University of Tokyo Faculty of Science Biochemistry
1977 - 1981 The University of Tokyo

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Professional career (2)：

Doctor(Science) (The University of Tokyo)
Master(Science) (The University of Tokyo)

Work history (13)：

2014/09 - 現在 Kyushu University
2002/04 - 現在 Kyushu University Medical Institute of Bioregulation
2002/04 - 現在 Professor, Kyushu University
2002/01 - 2002/03 (技術研究組合)生物分子工学研究所,主席研究員
2000/04 - 2002/03 Principal Research Scientist, Biomolecular Engineering Research Institute

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Committee career (12)：

2019/01 - 現在日本糖鎖科学コンソーシアム JCGG幹事
2017/07 - 現在日本糖質学会評議員
2017/04 - 現在日本生化学会代議員
2015/04 - 現在 wwPDB Advisory Committee
2014/04 - 現在大阪大学蛋白質研究所共同利用・共同研究委員会蛋白質立体構造データベース専門部会委員

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Association Membership(s) (13)：

THE CRYSTALLOGRAPHIC SOCIETY OF JAPAN , 日本糖質学会 , 日本生物物理学会 , 日本核磁気共鳴学会 , 日本蛋白質科学会 , 日本分子生物学会 , 日本生化学会 , The Japanese Society for Carbohydrate Research , the Biophysical Society of Japan , the Nuclear Magnetic Resonance Society of Japan , the Protein Science Society of Japan , The Molecular Biology Society of Japan , The Japanese Biochemical Society

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