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J-GLOBAL ID：200901097224820633 Update date: Dec. 19, 2024

Sakai Hideki

サカイヒデキ | Sakai Hideki

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.pha.u-toyama.ac.jp/phaphy1/index-j.html

Research field (6)： Clinical pharmacy , Physiology , Pharmacology , Pharmaceuticals - health and biochemistry , Pharmaceuticals - analytical and physicochemistry , Biophysics

Research keywords (6)：分子生理学 , 生物物理化学 , 薬物生理学 , Molecular Physiology , Biophysical Chemistry , Pharmaceutical Physiology

Research theme for competitive and other funds (12)：

2015 - 2017 細胞の生と死を司るアニオンチャネルの分子実体と制御機構の解明
2013 - 2016 胃酸分泌細胞の未知なる塩酸防御バリアの分子生理基盤解明
2012 - 2014 未知なる細胞容積感受性アニオンチャネルの分子構造基盤の解明
2009 - 2011 塩素イオンチャネルのSLC26A7と26A9による新規細胞防御機構の解明
2006 - 2010 Molecular physiological study of Cl-transport in gastric parietal cells

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Papers (68)：

Mizuki Katoh, Takuto Fujii, Yoshiaki Tabuchi, Takahiro Shimizu, Hideki Sakai. Negative regulation of thyroid adenoma-associated protein (THADA) in the cardiac glycoside-induced anti-cancer effect. The journal of physiological sciences : JPS. 2024. 74. 1. 23-23
Takuto Fujii, Takahiro Shimizu, Yukino Kaji, Mizuki Katoh, Hideki Sakai. Activation of mouse Otop3 proton channels by Zn2. Biochemical and biophysical research communications. 2023. 658. 55-61
Takuto Fujii, Shushi Nagamori, Pattama Wiriyasermkul, Shizhou Zheng, Asaka Yago, Takahiro Shimizu, Yoshiaki Tabuchi, Tomoyuki Okumura, Tsutomu Fujii, Hiroshi Takeshima, et al. Parkinson's disease-associated ATP13A2/PARK9 functions as a lysosomal H+,K+-ATPase. Nature communications. 2023. 14. 1. 2174-2174
Shimizu T, Fujii T, Hanita K, Shinozaki R, Takamura Y, Suzuki Y, Kageyama T, Kato M, Nishijo H, Tominaga M その他. Polycystic kidney disease 2-like 1 channel contributes to the bitter aftertaste perception of quinine. Scientific Reports. 2023. 13. 1
Takuto Fujii, Takahiro Shimizu, Hideki Sakai. [Novel pathophysiological functions of Na+,K+-ATPases and Cl- channels in cancer cells]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 2023. 158. 6. 465-468

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MISC (74)：

H. Mihara, H. Kishi, Y. Adachi, T. Shimizu, H. Sakai, M. Oku, A. Fujii. How Online Classes were Introduced to the Medical School Campus of a Regional University. Igaku Kyoiku. 2020. 51. 3. 255-257
Y. Okada, K. Sato-Numata, T. Shimizu, H. Sakai, T. Akita, T. Okada. Anion Channels Involved in Cell Survival-Death Switching. JOURNAL OF GENERAL PHYSIOLOGY. 2013. 142. 2. 12A-13A
Taiga Higuchi, Takahiro Shimizu, Takuto Fujii, Noriaki Takeguchi, Bernd Nilius, Hideki Sakai. Modulation of TRPP3 channel function by increasing temperature. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013. 63. S196-S196
Takahiro Shimizu, Yuta Takahashi, Takuto Fujii, Noriaki Takeguchi, Hideki Sakai. The role of Kv7.1 K+ channels in thromboxane A(2)-induced cell proliferation of human colonic cancer cells. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013. 63. S198-S198
Takuto Fujii, Yuji Takahashi, Kyosuke Fujita, Takahiro Shimizu, Noriaki Takeguchi, Hideki Sakai. Chloride-proton antiporter ClC-5 is functionally associated with gastric proton pump. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013. 63. S218-S218

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Books (2)：

Physiology of the Gastrointestinal Tract, Sixth Edition
Elsevier 2018
Metal Ions in Life Sciences
Walter de Gruyter GmbH 2016

Lectures and oral presentations (6)：

Regulation of the gastric H,K-ATPase activity by CLC-5.
(Molecular Mechanism and Regulation in Cation Transport ATPases and Related Genetic Diseases (Kyoto) 2006)
Regulation of the gastric H,K-ATPase activity by CLC-5.
(Molecular Mechanism and Regulation in Cation Transport ATPases and Related Genetic Diseases (Kyoto) 2006)
Up-regulation of thromboxane synthase in human colorectal cancer.
(US-Japan Conference on Drug Development & Rational Drug Design (Los Angeles) 2005)
Up-regulation of thromboxane synthase in human colorectal cancer.
(US-Japan Conference on Drug Development & Rational Drug Design (Los Angeles) 2005)
Mechanism of thromboxane A2-stimulated cell proliferation of human colonic cancer cells.
(The Physiological Society Meeting at King's College London (London) 2004)

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Works (2)：

腸管水分泌機構に及ぼす各種薬物の検討
2003 -
Effects of medicines on the water transport in intestine
2003 -

Education (4)：

- 1992 Toyama Medical and Pharmaceutical University
- 1992 Toyama Medical and Pharmaceutical University Graduate School, Division of Pharmaceutical Sciences
- 1985 Toyama Medical and Pharmaceutical University
- 1985 Toyama Medical and Pharmaceutical University Faculty of Pharmaceutical Science

Professional career (1)：

Ph.D.(Pharmacy) (*Toyama Medical and Pharmaceutical University*)

Work history (17)：

2006/04 - University of Toyama Graduate School of Medicine and Pharmaceutical Sciences for Research
2005/10 - University of Toyama Faculty of Pharmacy and Pharmaceutical Sciences
2005/10 - University of Toyama, Professor
2005/02 - Toyama Medical and Pharmaceutical University
2005/02 - Toyama Medical and Pharmaceutical University,

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Committee career (1)：

日本生理学会評議員

Awards (3)：

2001 - とやま賞
1999 - 日本薬学会奨励賞
1992 - 井上研究奨励賞

Association Membership(s) (8)：

英国生理学会 , 日本生物物理学会 , 日本薬学会 , 日本生理学会 , The Physiological Society (UK) , The Biophysical Society of Japan , The Pharmaceutical Society of Japan , The Physiological Society of Japan

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