Rchr
J-GLOBAL ID：200901097392001460   Update date: May. 01, 2024

Ohashi Kazumasa

オオハシ カズマサ | Ohashi Kazumasa
Affiliation and department：
Tohoku University Graduate School of Life Sciences Department of Biomolecular Sciences Division of Molecular Biosystems Laboratory of Molecular and Cellular Biology

About Tohoku University Graduate School of Life Sciences Department of Biomolecular Sciences Division of Molecular Biosystems Laboratory of Molecular and Cellular Biology


Job title： Associate Professor
Homepage URL  (1)： http://www.biology.tohoku.ac.jp/lab-www/ohashi_lab/
Research field  (2)： Functional biochemistry ,  Cell biology
Research keywords  (7)： 中間径フィラメント ,  mechanobiology ,  Live imaging ,  cancer ,  Rho-GEF ,  mechanoresponse ,  actin cytoskeleton
Research theme for competitive and other funds  (28)：
  • 2022 - 2024 Function of Solo, a RhoGEF, involved in mechanical stress response in the homeostasis of epithelial cell population
  • 2022 - 2023 上皮細胞集団の力学的秩序を制御する分子機構の解明
  • 2021 - 2023 Development of a tension sensor probe to Visualize the tensile force subjected to Cells
  • 2020 - 2023 RhoGEF, Soloとケラチン繊維による細胞の機械刺激に対する順応機構の解明
  • 2021 - 2022 細胞の力学的環境を感知するメカノセンサー蛋白質の同定
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Papers (93)：
  • Aoi Kunitomi, Shuhei Chiba, Nahoko Higashitani, Atsushi Higashitani, Shinichi Sato, Kensaku Mizuno, Kazumasa Ohashi. Solo regulates the localization and activity of PDZ-RhoGEF for actin cytoskeletal remodeling in response to substrate stiffness. Molecular Biology of the Cell. 2024
  • Komaki Ninomiya, Kai Ohta, Ukyo Kawasaki, Shuhei Chiba, Takanari Inoue, Erina Kuranaga, Kazumasa Ohashi, Kensaku Mizuno. Calcium influx promotes PLEKHG4B localization to cell-cell junctions and regulates the integrity of junctional actin filaments. Molecular biology of the cell. 2023. mbcE23050154
  • Toshiaki Mishima, Yusaku Ohta, Kazumasa Ohashi, Kensaku Mizuno. MARK3-mediated Slingshot-1 phosphorylation is essential for polarized lamellipodium formation. 2023
  • 國富 葵, 千葉 秀平, 東谷 篤志, 東谷 なほ子, 水野 健作, 大橋 一正. SoloとPDZ-RhoGEFの相互作用を介したメカノストレス応答におけるアクチン骨格の制御機構. 日本生化学会大会プログラム・講演要旨集. 2023. 96回. [1P-251]
  • Komaki Ninomiya, Kai Ohta, Kazunari Yamashita, Kensaku Mizuno, Kazumasa Ohashi. PLEKHG4B enables actin cytoskeletal remodeling during epithelial cell-cell junction formation. Journal of Cell Science. 2021. 134. 2. jcs249078-jcs249078
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MISC (40)：
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Books (3)：
  • Methods in Molecular Biology, Exocytosis and Endocytosis
    Springer New York 2014
  • 遺伝子医学MOOK6 シグナル伝達病を知る 菅村和夫編
    メディカルドゥ 2006
  • わかる実験医学シリーズ 細胞骨格・運動がわかる 三木裕明編
    羊土社 2004
Lectures and oral presentations  (177)：
  • Functions and molecular mechanisms of Solo, a RhoGEF, in mechanical stress responses
    (International Symposium on Mechanobiology for Human Health: 8 years progress in The AMED-CREST/PRIME project on mechanobiology 2023)
  • Solo, a RhoGEF involved in mechanoresponse, requires plakoglobin to localize to cell-cell adhesion sites
    (2022)
  • Analysis of interaction between PDZ-RhoGEF and Solo, a RhoGEF involved in mechanoresponse
    (2022)
  • Calcium influx promotes junctional localization of Cdc42-targeting GEF, PLEKHG4B, to organize junctional action structure in epithelial cells
    (2022)
  • Screening of RhoGEFs involved in adipocyte differentiation of mesenchymal stem cells
    (2022)
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Education (3)：
  • 1996 - 1996 Kyushu University
  • 1993 - 1996 Kyushu University
  • 1991 - 1993 Kyushu University
Professional career (1)：
  • 博士(理学) (九州大学)
Work history (3)：
  • 2017/04 - 現在 Tohoku University Molecular and Cellular Biology, Graduate School of Life Sciences Professor
  • 2001/04 - 2017/03 Tohoku University Molecular Cell Biology, Department of Biomolecular Sciences Graduate School of Life Sciences Associate Professor
  • 1999/07 - 2001/03 Tohoku. Univ. Biologycal Institute, Faculty of Science Assistant Professor
Committee career (6)：
  • 2019/04 - 2020/03 日本細胞生物学会 CSF編集委員
  • 2018/04 - 2019/03 日本細胞生物学会 CSF編集委員
  • 2014/04 - 2018/03 The Japanese Biochemical Society 雑誌編集委員
  • 2014/04 - 2018/03 日本生化学会 雑誌編集委員
  • 2012/04 - 2015/03 Japan Society for Cell Biology 評議員
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Awards (2)：
  • 2007/05/12 - 日本生化学会東北支部会 第7回日本生化学会東北支部奨励賞 血管内皮細胞の遊走におけるLIMキナーゼの活性化と新たなシグナル伝達経路の解明
  • 1997/02 - 井上科学振興財団 井上研究奨励賞 新規受容体型チロシンキナーゼSkyとそのリガンドの同定
Association Membership(s) (6)：
American Society for Cell Biology (ASCB) ,  日本神経科学学会 ,  日本ガン学会 ,  日本細胞生物学会 ,  日本分子生物学会 ,  日本生化学会
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