Research keywords (7):
Antibody-like protein
, リボソーム
, 遺伝暗号
, 非天然アミノ酸
, ペプチド
, タンパク質
, 翻訳反応
Research theme for competitive and other funds (9):
2023 - 2028 Development of single-molecule peptide sequencing method
2021 - 2025 抗体医薬を真に置き換える小タンパク質医薬の開発
2015 - 2019 高速人工抗体創製法 の開発とタンパク質 1分子単位定量への 応用
2015 - 2016 新遺伝暗号の創成
2010 - 2014 JSPS 特殊ペプチド増幅法の開発と創薬への応
2008 - 2011 ポリペプチド翻訳合成:D体アミノ酸とベータアミノ酸への新展開
2011 - 2011 広汎用リボソームの開発
2004 - 2008 Generation of ribozymes that catalyze fatty acid biosynthesis
2005 - 2007 新規アミノアシルtRNA合成リボザイムの創製
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Papers (61):
Shun Umemoto, Taishi Kondo, Tomoshige Fujino, Gosuke Hayashi, Hiroshi Murakami. Large-scale analysis of mRNA sequences localized near the start and amber codons and their impact on the diversity of mRNA display libraries. Nucleic Acids Research. 2023. 51. 14. 7465-7479
Koki Nakatsu, Akimitsu Okamoto, Gosuke Hayashi, Hiroshi Murakami. Repetitive Thiazolidine Deprotection Using a Thioester-Compatible Aldehyde Scavenger for One-Pot Multiple Peptide Ligation**. Angewandte Chemie International Edition. 2022. 61. 39
Taishi Kondo, Kazuhiro Matsuoka, Shun Umemoto, Tomoshige Fujino, Gosuke Hayashi, Yasumasa Iwatani, Hiroshi Murakami. Monobodies with potent neutralizing activity against SARS-CoV-2 Delta and other variants of concern. Life Science Alliance. 2022. 5. 6
Taishi Kondo, Minori Eguchi, Nariaki Tsuzuki, Naoya Murata, Tomoshige Fujino, Gosuke Hayashi, Hiroshi Murakami. Construction of a highly diverse mRNA library for in vitro selection of monobodies. Bio-protocol. 2021. 11. 16