Kanai Motomu

カナイモトム | Kanai Motomu

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.f.u-tokyo.ac.jp/~kanai/index.html

Research field (1)： Pharmaceuticals - chemistry and drug development

Research keywords (2)：有機化学 , Organic Chemistry

Research theme for competitive and other funds (44)：

2023 - 2027 Elucidation of the role of autophagy in photo-oxygenated amyloid degradation
2021 - 2024 Chemical glycan modification of membrane proteins for "manipulating" membrane dynamics
2020 - 2024 生体分子の構造変換ダイナミズムに介入する化学触媒研究
2022 - 2023 分子合成オンデマンドを実現するハイブリッド触媒系の創製
2020 - 2023 超高性能クライオEMの分子プローブ創製

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Papers (207)：

Reito Nakamura, Ikumi Tomizawa, Atsushi Iwai, Tetsuo Ikeda, Kota Hirayama, Yung Wen Chiu, Takanobu Suzuki, Airi Tarutani, Tatsuo Mano, Atsushi Iwata, et al. Photo-oxygenation of histidine residue inhibits α-synuclein aggregation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2023. 37. 12. e23311
Akiko Fujimura, Hisashi Ishida, Tamiko Nozaki, Shuhei Terada, Yuto Azumaya, Tadashi Ishiguro, Yugo R Kamimura, Tomoya Kujirai, Hitoshi Kurumizaka, Hidetoshi Kono, et al. Designer Adaptor Proteins for Functional Conversion of Peptides to Small-Molecule Ligands toward In-Cell Catalytic Protein Modification. ACS central science. 2023. 9. 11. 2115-2128
Toshifumi Tatsumi, Koki Sasamoto, Takuya Matsumoto, Ryo Hirano, Kazuki Oikawa, Masato Nakano, Masaru Yoshida, Kounosuke Oisaki, Motomu Kanai. Practical N-to-C peptide synthesis with minimal protecting groups. Communications Chemistry. 2023. 6. 1
Juri Sakata, Toshifumi Tatsumi, Akira Sugiyama, Akihiro Shimizu, Yuya Inagaki, Hiroto Katoh, Takefumi Yamashita, Kazuki Takahashi, Sho Aki, Yudai Kaneko, et al. Antibody-mimetic drug conjugate with efficient internalization activity using anti-HER2 VHH and duocarmycin. Protein expression and purification. 2023. 106375-106375
Hiroki Umeda, Taka Sawazaki, Masahiro Furuta, Takanobu Suzuki, Shigehiro A Kawashima, Harunobu Mitsunuma, Yukiko Hori, Taisuke Tomita, Youhei Sohma, Motomu Kanai. Quantitative Assays for Catalytic Photo-Oxygenation of Alzheimer Disease-Related Tau Proteins. ACS chemical neuroscience. 2023. 14. 15. 2710-2716

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MISC (295)：

金井求, 生長幸之助, 豊邉萌. レドックス活性を利用した抗体修飾と応用. MEDCHEM NEWS. 2023. 33. 1. 33-37
浅井秀一朗, 渡邉謙一, 相馬洋平, 金井求, 堀由起子, 富田泰輔. AAアミロイドーシス治療を目指した光酸素化法の検証. 日本アミロイドーシス学会学術集会プログラム・抄録集. 2023. 10th
栗山摩衣, 鈴木崇允, 澤崎鷹, 澤崎鷹, 相馬洋平, 相馬洋平, 金井求, 堀由起子, 富田泰輔. 細胞内凝集タウに対する光酸素化の薬効の評価. Dementia Japan. 2023. 37. 4
中川葉奈子, 鈴木崇允, 澤崎鷹, 澤崎鷹, 相馬洋平, 相馬洋平, 金井求, 堀由起子, 富田泰輔. Elucidation of mechanism of the aggregated tau clearance by photo-oxygenation. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
古田将大, 堀由起子, 富田泰輔, 相馬洋平, 三ツ沼治信, 三ツ沼治信, 金井求. Development of highly active photooxygenation catalysts for amyloids toward in-vivo applications. 日本薬学会年会要旨集(Web). 2023. 143rd

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Patents (2)：

配位子及びそれを用いた不斉触媒
Chiral Ligands and Enantioselective Catalysts

Education (4)：

- 1995 Osaka University
- 1995 Osaka University Graduate School, Division of Natural Science
- 1989 The University of Tokyo Faculty of Pharmaceutical Sciences
- 1989 The University of Tokyo Faculty of Pharmaceutical Science

Professional career (2)：

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Work history (9)：

2010/04 - 現在 The University of Tokyo Graduate School of Pharmaceutical Sciences
2003 - 2010/03 - 同助教授
2000 - 2003 The University of Tokyo Graduate School of Pharmaceutical Sciences
2000 - 2003 Grad. School. of Pharm. Sci. The Univ. of Tokyo. Lecturer
2003 - - sssociate professor

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Awards (9)：

2022/07 - 産経新聞社独創性を拓く先端技術大賞社会人部門特別賞アミロイド選択的光酸素化技術によるアミロイド病態治療 ~アルツハイマー病、さらにはアミロイドーシスの根本治療法開発を目指して~
2022/03 - Nagoya Silver Medal
2016 - トムソン・ロイター第4回リサーチフロントアワード
2011 - Novartis Lecturer in Organic Chemistry (2011年)
2005 - Merck-Banyu Lectureship Award

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Association Membership(s) (4)：

アメリカ化学会 , 有機合成化学協会 , 日本化学会 , 日本薬学会

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