Research theme for competitive and other funds (43):
2023 - 2026 Investigation of genetic variants and clinical risk factors associated with the progression rate of visual field defect in glaucoma
2022 - 2025 The Effects of the Act on the Safety of Regenerative Medicine in Japanese Research and Development
2022 - 2025 The impacts of providing learning environments based on visual function on low-vision children enrolled in regular classes
2022 - 2025 Integral analysis of the cellular microenvironment aiming in vivo control of corneal endothelial cell fate
2022 - 2025 Verification of microbial involvement in the pathogenesis of ocular complications of SJS/TEN, pathogenesis and prediction
2021 - 2024 Establishing a Risk Prediction Method for Primary Open Angle Glaucoma Using Next Generation Sequencer and Analysis on Non-synonymous Valiant
2020 - 2023 Relationship between primary cilia and corneal endothelial disease in corneal endothelial cells and their function
2020 - 2023 Identification and kinetic analysis of glaucoma resistance gene with primary open angle glaucoma
2020 - 2023 遺伝解析の統計的検出力を高めるための緑内障臨床情報クラスタリング手法の開発
2019 - 2022 Analysis of microenvironment of corneal transplantation to elucidate the molecular mechanism of failed adaptation of corneal graft to the host environment
2019 - 2022 Strategic research to understand the pathogenesis and improve the prognosis of SJS/TEN by multilayered omics analysis
2018 - 2021 Development of treatments for age-related macular degeneration targeting fibrosis suppression and neuroprotective effects
2017 - 2021 Evaluation of genetic factors for deterioration of primary open angle glaucoma
2018 - 2021 SJS/TEN眼後遺症に向けた戦略的研究
2017 - 2020 Identification of responsible genomic region of Primary Open Angle Glaucoma with International Consortium
2017 - 2020 難治性眼表面疾患に対する培養自家口腔蓮膜シート移植
2016 - 2019 Invetigation of pathogensis of SJS/TEN
2014 - 2017 エネルギー応答を指標とする角膜内皮障害の創薬標的と早期診断基盤技術の開発
2012 - 2016 患者支援に基づくSJS/TEN後遺症の発症予防と治療法の確立
2013 - 2015 重症多型浸出性紅斑眼障害の克服に向けた新規医療機器の開発
2013 - 2015 SJS/TENの発症機序解明および発症予測に向けた国際的研究
2011 - 2013 メタボローム解析に基づくアミノ酸含有人工涙液の開発
2011 - 2013 特発性周辺部角膜潰瘍の診断および治療に関する研究
2011 - 2013 涙液中アミノ酸発現が眼表面疾患の病態に及ぼす影響
2010 - 2013 視覚障害介護対象者の社会生活向上のためのスクレラルレンズの開発
2010 - 2013 SJS/TENの発症機序解明および発症予測に向けた先駆的研究
2010 - 2012 重症薬疹の発症予測に有用な普及型鑑別診断法の開発
2010 - 2012 遺伝子多型解析による重症薬疹発症予測アルゴリズムの開発
2010 - 2012 The effects of low vision care program added environmental coordination
2010 - 2011 特発性周辺部角膜潰瘍の実態調査および診断基準の確立
2007 - 2009 SJS/TENの新規治療法開発に向けての戦略的研究
2005 - 2007 Stevens-Johnson症候群の発症機序と病態に関する解析
2000 - 2002 Neuroprotective effects by retinal glial cells
1999 - 2001 角膜上皮増殖におけるEGF受容体の役割
2000 - 2001 Functional analysis and genomic mapping of corneal epithelium-specific genes and detection of disease-related genes among ocular surface disorders.
1998 - 2000 網膜グリア細胞における血管新生作用
1997 - 1999 角膜をとりまく生体環境におけるFas-FasL systemの発現
眼表面および涙液における各種サイトカインの発現
ぶどう膜炎患者の眼内液におけるsoluble Fas liandの発現
アルカリ外傷角膜におけるサイトカインの発現
Cytokine expression in the ocular surface including tear film
The expresssion of soluble Fas ligand in ocular fluid of uveitis patients
Cytokine expression in the alkali-burned cornea
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Papers (629):
Akifumi Matsumoto, Hideki Fukuoka, Chie Sotozono. Descemet's Membrane Detachment During Cataract Surgery in Lattice Corneal Dystrophy Type I: Histopathological Analysis of Posterior Corneal Involvement. Cureus. 2025
Hiroki Mieno, Kazuhiko Mori, Kengo Yoshii, Yo Okada, Yoko Ikeda, Morio Ueno, Chie Sotozono. Risk factors and protective strategies for hypotony following preserflo microshunt implantation. Scientific reports. 2025. 15. 1. 8344-8344
Noriko Koizumi, Dai Miyazaki, Seiichiro Sugita, Chie Sotozono, Tsutomu Inatomi, Hiroshi Goto, Atsushi Shiraishi, Shuichiro Eguchi, Shin-Ichiro Ito, Yuichi Hori, et al. Efficacy and safety of ROH-101 (0.15% ganciclovir gel) for cytomegalovirus corneal endotheliitis: an open-label, uncontrolled, phase 3 study in Japan. Japanese journal of ophthalmology. 2025. 69. 2. 296-307
Mako Watanabe, Koji Kitazawa, Hideki Fukuoka, Koichi Wakimasu, Tsutomu Inatomi, Kengo Yoshii, Noriko Koizumi, Shigeru Kinoshita, Chie Sotozono. Predictors of cytomegalovirus corneal endotheliitis postcorneal transplantation. The British journal of ophthalmology. 2024
Toru Ikushima, Aiko Iwase, Makoto Araie, Hiroshi Murata, Morio Ueno, Kazuhiko Mori, Yoko Ikeda, Hiroki Mieno, Chie Sotozono, Shigeru Kinoshita, et al. Effects of ambient atmospheric pressure on intraocular pressure measured using a Goldman applanation tonometer in normal eyes under ordinary conditions. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 2024
宮平 大, 上野 盛夫, 吉井 健悟, 三重野 洋喜, 森 和彦, 外園 千恵. スーチャー線維柱帯切開術眼内法の術後ごく早期の眼圧動態-Intraocular Pressure Dynamics in the Early Postoperative Period of Suture Trabeculotomy. 日本眼科學會雜誌 = Journal of Japanese Ophthalmological Society. 2025. 129. 1. 36-42
Regenerative ophthalmology and LSCD: Severe ocular surface disorders (Stevens-Johnson syndrome, Chemical injury)
(The 8th Asia Cornea Society 2022 (ACS) 2022)
Mooren’s ulcer
(The 8th Asia Cornea Society 2022 (ACS) 2022)
Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
(American Academy of Ophthalmology (AAO)2022 2022)
Current Benchmarks in the Use of COMET for Severe Ocular Surface Disorders
(World Cornea Congress VIII 2022)
Sub-acute and chronic management of ocular sequele in Stevens-Johnson Syndrome
(Comprehensive management in ocular surface problems 2022)