Hagiwara Ken'ichi

ハギワラケンイチ | Hagiwara Ken'ichi

Affiliation and department：
Job title： Laboratory of Biomacromolecule Analysis
Homepage URL (1)： http://www.nih.go.jp/niid/ja/from-biochem/2294-1st-laboratory-home.html

Research field (5)： Virology , Pharmaceuticals - analytical and physicochemistry , Pharmaceuticals - health and biochemistry , Neuroscience - general , Molecular biology

Research keywords (5)： prion , neurodegenerative diseases , neurochemistry , bioactive peptides , analytical chemistry

Research theme for competitive and other funds (18)：

2018 - 2021 Investigation of the folding mechanism of PrPC to PrPSc and assembly of prion agents, and interpretation of the of the beta helix scaffold model
2017 - 2020 食品を介する家畜・家禽疾病のリスク管理に関する研究
2014 - 2017 非定型BSE(牛海綿状脳症)に対する安全対策等に関する研究
2011 - 2014 食品を介する伝達性海綿状脳症のリスクと対策等に関する研究
2008 - 2011 食品を介するBSEリスクの解明等に関する研究

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Papers (48)：

Yuko Okemoto-Nakamura, Isei Tanida I, Toshiyuki Yamaji, Kentaro Hanada, Ken'ichi Hagiwara. A PRNP-Disrupted Human Neuroblastoma Cell Line and Its Stable Transformants Expressing Prion Protein Variants. BPB Reports. 2019. 2. 5. 73-79
Ken’ichi Hagiwara, Yuko Sato, Yoshio Yamakawa, Hideyuki Hara, Minoru Tobiume, Yuko Okemoto-Nakamura, Tetsutaro Sata, Motohiro Horiuchi, Hiroaki Shibata, Fumiko Ono. Tracking and clarifying differential traits of classical- and atypical L-type bovine spongiform encephalopathy prions after transmission from cattle to cynomolgus monkeys. PLOS ONE. 2019. 14. 5. e0216807-e0216807
Ken'ichi Hagiwara, Yoshifumi Iwamaru, Naoko Tabeta, Takashi Yokoyama, Minoru Tobiume. Evaluation of rapid post-mortem test kits for bovine spongiform encephalopathy (BSE) screening in Japan: Their analytical sensitivity to atypical BSE prions. Prion. 2017. 11. 2. 113-127
H. Hara, Y. Okemoto-Nakamura, F. Shinkai-Ouchi, K. Hanada, Y. Yamakawa, K. Hagiwara. Mouse prion protein (PrP) segment 100 to 104 regulates conversion of PrPC to PrPSc in prion-Infected neuroblastoma cells. Journal of Virology. 2012. 86. 10. 5626-5636
Fumiko Ono, Naomi Tase, Asuka Kurosawa, Akio Hiyaoka, Atsushi Ohyama, Yukio Tezuka, Naomi Wada, Yuko Satol, Minoru Tobiume, Ken'ichi Hagiwara, et al. Atypical L-type bovine spongiform encephalopathy (L-BSE) transmission to cynomolgus macaques, a non-human primate. Japanese Journal of Infectious Diseases. 2011. 64. 1. 81-84

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MISC (24)：

K. Hagiwara, H. Hara, K. Hanada. Species-barrier phenomenon in prion transmissibility from a viewpoint of protein science. Journal of Biochemistry. 2013. 153. 2. 139-145
松浦裕一, 石川有紀子, SOMERVILLE Robert, 横山隆, 萩原健一, 山河芳夫, 佐田徹太郎, 北本哲之, 毛利資郎. BSEの感染性はウシ化マウスへの腹腔内投与により75日で判定できる. 農研機構動物衛生研究所成果情報(Web). 2013. 2013
中村優子, 萩原健一. 【食の安全を守る】BSE問題におけるリスク管理とその変遷. ファルマシア. 2013. 49. 1. 48-51
岩丸祥史, 今村守一, 松浦裕一, 舛甚賢太郎, 清水善久, 舒宇静, 倉知恵美, 河西和雄, 村山裕一, 福田茂夫, et al. 非定型BSEプリオンは,定型BSEプリオンと同じく末梢神経に分布する. 動物衛生研究成果情報. 2011. 10. 57-58
Yuko Okemoto-Nakamura, Hideyuki Hara, Funniko Shinkai-Ouchi, Yoshio Yamakawa, Kentaro Hanada, Ken'ichi Hagiwara. Analysis of Synaptic Proteins and Cdk5 in Prion Protein-Deficient Cells. PRION. 2011. 5. 72-72

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Books (4)：

分析試料前処理ハンドブック[中村洋編]
丸善 2003
機器分析ガイドブック[日本分析化学会編]
丸善 1997
内分泌生理化学[矢内原昇編]
南江堂 1994
(続)生化学実験講座2 タンパク質の化学(上)[日本生化学会編]
1987

Professional career (1)：

PhD (Pharmaceutical Sciences)

Work history (6)：

2021/04 - 現在 National Institute of Infectious Diseases
2006/04 - 2021/03 National Institute of Infectious Diseases
2001 - 2006 National Institute of Infectious Diseases
1997 - 2000 科学技術振興事業団「脳を知る」東京大学理学系研究科博士研究員
1995 - 1997 英・オクスフォード大学博士研究員

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Committee career (2)：

2006/04 - 2021/03 Ministry of Health, Labour and Welfare Members of the expert committee for the testing of bovine spongiform encephalopathy
2014/01 - 2020/12 The Japanese Society for Bacteriology, The Japanese Society for Virology, and The Japanese Society for Host Defense Research. Editorial Board, Microbiology and Immunology

Association Membership(s) (1)：

日本生化学会

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