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J-GLOBAL ID：201001025989357940 Update date: Mar. 07, 2025

Hamamoto Shuzo

ハマモトシュウゾウ | Hamamoto Shuzo

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Affiliation and department：
Job title：講師

Research field (1)： Urology

Research theme for competitive and other funds (35)：

2022 - 2026 生体内免疫応答と修復機構の統合的解析による尿路結石の病態解明と溶解療法への展開
2021 - 2026 疾患iPS細胞由来腎オルガノイドの樹立による新規腎結石モデルと結石溶解療法の開発
2022 - 2025 シングルセル解析を用いたオートファジー依存型結石抑制遺伝子の同定
2022 - 2025 低酸素環境での腎結石形成機序の解明とプロリン水酸化酵素阻害剤による治療法の開発
2022 - 2025 フェムト秒レーザーを用いた新たな尿路結石治療法の開発

2021 - 2024 抗酸化遺伝子Nntによる尿路結石抑制機構を用いた予防治療への検討

2020 - 2023 分子生物学・鉱物学・隕石学の融合による尿路結石の形成機序解明と新規予防法の創設

2020 - 2023 尿路結石マトリックス蛋白オステオポンチンを標的としたマクロファージ貪食機序の解明

2020 - 2023 メタボリックシンドロームにおける細胞接着分子の発現と腎結石促進機序の解明

2019 - 2023 酸素ナノバブル水による腎結石形成の抑制機序の解明と予防法の開発

2019 - 2023 酸化ストレス活性化転写因子Nrf2をターゲットとした尿路結石症予防法の開発

2019 - 2023 Development and drug discovery for urolithiasis by integrated analysis of bio-repair mechanisms

2018 - 2022 Elucidation of the suppression mechanism and application to preventive treatment by the novel related gene Nnt of urolithiasis

2018 - 2022 Development of a new preventive drug for urinary calculus focusing on the anti-metabolic syndrome effect of beige cells

2018 - 2022 Development of medication for urolithiasis via selective autophagy

2018 - 2021 Establishment of a novel biomarker for renal calculi

2017 - 2020 Elucidation and clinical application of a novel method for preventing urolithiasis focusing on the antioxidant effect of estrogen

2017 - 2020 Elucidation of the mechanism of the kidney stone formation related by kidney differentiation inducing factor and its application to treatment

2016 - 2019 Elucidation of suppression mechanism for kidney stone formation by oxygen nano bubble water and application to the prevention method

2016 - 2019 Omics analysis of macrophage-related molecules for urolithiasis dissolution therapy

2016 - 2019 Development of the biomaker of kidney stone formation

2015 - 2018 The role of the cleaved osteopintin in stone formation

2015 - 2018 Elucidation of the pathology of mitochondrial injury during urinary calculi formation and development of prevention.

2013 - 2016 Establishment of the new concept, 'spontaneous elimination of kidney stones' and application to development of the dissolution therapy

2013 - 2016 Investigation of the effect of anti-osteopontin antibody on renal crystal formation

2012 - 2015 The antiapoptosis effect of the heat receptor (TRPV1)-promoter for the prevention of kidney stone.

2012 - 2015 The development of a specific anti-OPN antibody which contributes to to the remarkable inhibition of early stage of renal crystal formation

2012 - 2015 The functional analysis of kidney stone-phagocytosis activity by the macrophages and the application to dissolution therapy.

2012 - 2015 Biomolecular mechanism of urinary stone formation, and development of medicine

2012 - 2015 A new treatment agent determining renal calcium crystallization through cyclophilin D activation.

2011 - 2015 Integrated elucidation of the urinary stone formation mechanism considered from heredity and environment factors, and development of the new therapeutic medicines

2011 - 2013 Development of prophylaxis by the elucidation of the pathogenesis in the initial urinary stone formation

2010 - 2011 Effects of functional domains of osteopontin on renal crystal formation

2009 - 2010 尿路結石予防を目的としたオステンポンチン機能的アミノ酸配列の役割解明

2009 - 2010 The elucidation of the kidney stone formation mechanism from a microstructural change and the oxidative stress of the renal tubular epithelial cell.

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Papers (346)：

Takahiro Yanase, Taku Naiki, Aya Naiki-Ito, Ryosei Okawa, Sosuke Niwa, Nobuhiko Shimizu, Shuzo Hamamoto, Yoshiaki Fujii, Hiroki Takahashi, Takahiro Yasui. Efficacy of prostatectomy using a Retzius-sparing approach as an additional excision in anal canal carcinoma after brachytherapy for prostate adenocarcinoma. IJU case reports. 2025. 8. 2. 174-178
Yoshihiko Tasaki, Shuzo Hamamoto, Shimpei Yamashita, Junya Furukawa, Kazutoshi Fujita, Ryotaro Tomida, Makito Miyake, Noriyuki Ito, Hideto Iwamoto, Yoshihisa Mimura, et al. Eosinophil is a predictor of severe immune-related adverse events induced by ipilimumab plus nivolumab therapy in patients with renal cell carcinoma: a retrospective multicenter cohort study. Frontiers in Immunology. 2025. 15
Taku Naiki, Aya Naiki-Ito, Akihiro Murakami, Hiroyuki Kato, Yosuke Sugiyama, Tatsuya Kawai, Shinji Kato, Toshiki Etani, Takashi Nagai, Nobuhiko Shimizu, et al. Preliminary Evidence on Safety and Clinical Efficacy of Luteolin for Patients With Prostate Cancer Under Active Surveillance. Prostate cancer. 2025. 2025. 8165686-8165686
Toshiharu Morikawa, Shuzo Hamamoto, Masakazu Gonda, Kazumi Taguchi, Rei Unno, Koei Torii, Masahiko Isogai, Kengo Kawase, Takashi Nagai, Shoichiro Iwatsuki, et al. Evaluation of thermal effects of surgical energy devices: ex vivo study. Scientific reports. 2024. 14. 1. 27365-27365
Shuzo Hamamoto, Yoshihiko Tasaki, Shimpei Yamashita, Junya Furukawa, Kazutoshi Fujita, Ryotaro Tomida, Makito Miyake, Noriyuki Ito, Hideto Iwamoto, Yosuke Sugiyama, et al. External validation of hemoglobin and neutrophil levels as predictors of the effectiveness of ipilimumab plus nivolumab for treating renal cell carcinoma. Frontiers in Oncology. 2024. 14

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MISC (226)：

森川敏治, 森川敏治, 浜本周造, 最上徹, 安井孝周. エネルギーデバイスによる熱障害の研究. 日本内視鏡外科学会総会(Web). 2023. 36th
杉野輝明, 浜本周造, 鬼頭拓未, 森川敏治, 磯谷正彦, 須江保仁, 服部竜也, 海野怜, 田口和己, 安藤亮介, et al. ECIRSにおける開脚腹臥位と修正Valdivia位の無作為化比較試験. 日本泌尿器科学会中部総会プログラム・抄録集. 2022. 72nd
Takaaki Inoue, Shinsuke Okada, Shuzo Hamamoto, Masato Fujisawa. Retrograde intrarenal surgery: Past, present, and future. Investigative and Clinical Urology. 2021. 62. 2. 121-135
Kazumi Taguchi, Shuzo Hamamoto, Satoshi Osaga, Teruaki Sugino, Rei Unno, Ryosuke Ando, Atsushi Okada, Takahiro Yasui. Comparison of antegrade and retrograde ureterolithotripsy for proximal ureteral stones: A systematic review and meta-analysis. Translational Andrology and Urology. 2021. 10. 3. 1179-1191
小早川祐輝, 浜本周造, 磯部輝紀, 森川敏晴, 冨山奈美, 松本大輔, 松山奈有佳, 岩月正一郎, 惠谷俊紀, 内木拓, et al. 転移性腎細胞癌に対して術前免疫療法を行った症例の検討. 日本泌尿器科学会総会(Web). 2021. 109th

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