Hamamoto Shuzo

2021 - 2024 抗酸化遺伝子Nntによる尿路結石抑制機構を用いた予防治療への検討

2020 - 2023 分子生物学・鉱物学・隕石学の融合による尿路結石の形成機序解明と新規予防法の創設

2020 - 2023 尿路結石マトリックス蛋白オステオポンチンを標的としたマクロファージ貪食機序の解明

2020 - 2023 メタボリックシンドロームにおける細胞接着分子の発現と腎結石促進機序の解明

2019 - 2023 酸素ナノバブル水による腎結石形成の抑制機序の解明と予防法の開発

2019 - 2023 酸化ストレス活性化転写因子Nrf2をターゲットとした尿路結石症予防法の開発

2019 - 2023 Development and drug discovery for urolithiasis by integrated analysis of bio-repair mechanisms

2018 - 2022 Elucidation of the suppression mechanism and application to preventive treatment by the novel related gene Nnt of urolithiasis

2018 - 2022 Development of a new preventive drug for urinary calculus focusing on the anti-metabolic syndrome effect of beige cells

2018 - 2022 Development of medication for urolithiasis via selective autophagy

2018 - 2021 Establishment of a novel biomarker for renal calculi

2017 - 2020 Elucidation and clinical application of a novel method for preventing urolithiasis focusing on the antioxidant effect of estrogen

2017 - 2020 Elucidation of the mechanism of the kidney stone formation related by kidney differentiation inducing factor and its application to treatment

2016 - 2019 Elucidation of suppression mechanism for kidney stone formation by oxygen nano bubble water and application to the prevention method

2016 - 2019 Omics analysis of macrophage-related molecules for urolithiasis dissolution therapy

2016 - 2019 Development of the biomaker of kidney stone formation

2015 - 2018 The role of the cleaved osteopintin in stone formation

2015 - 2018 Elucidation of the pathology of mitochondrial injury during urinary calculi formation and development of prevention.

2013 - 2016 Establishment of the new concept, 'spontaneous elimination of kidney stones' and application to development of the dissolution therapy

2013 - 2016 Investigation of the effect of anti-osteopontin antibody on renal crystal formation

2012 - 2015 The antiapoptosis effect of the heat receptor (TRPV1)-promoter for the prevention of kidney stone.

2012 - 2015 The development of a specific anti-OPN antibody which contributes to to the remarkable inhibition of early stage of renal crystal formation

2012 - 2015 The functional analysis of kidney stone-phagocytosis activity by the macrophages and the application to dissolution therapy.

2012 - 2015 Biomolecular mechanism of urinary stone formation, and development of medicine

2012 - 2015 A new treatment agent determining renal calcium crystallization through cyclophilin D activation.

2011 - 2015 Integrated elucidation of the urinary stone formation mechanism considered from heredity and environment factors, and development of the new therapeutic medicines

2011 - 2013 Development of prophylaxis by the elucidation of the pathogenesis in the initial urinary stone formation

2010 - 2011 Effects of functional domains of osteopontin on renal crystal formation

2009 - 2010 尿路結石予防を目的としたオステンポンチン機能的アミノ酸配列の役割解明

2009 - 2010 The elucidation of the kidney stone formation mechanism from a microstructural change and the oxidative stress of the renal tubular epithelial cell.