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J-GLOBAL ID：201001034801338144   Update date: Jan. 07, 2025

KEN YOKOYAMA

KEN YOKOYAMA
Research field  (4)： Functional biochemistry ,  Biophysics ,  Cell biology ,  Structural biochemistry
Research keywords  (9)： sensor protein ,  FoF1 ,  F1 ,  rotary molecular motor ,  ATP synthase ,  CryoEM ,  ATP ,  生体エネルギー ,  V-ATPase
Research theme for competitive and other funds  (23)：
  • 2020 - 2023 クライオ電子顕微鏡による V型ATPaseの回転機構の解明
  • 2017 - 2020 Structural analysis for vacuolar type ATPase to reveal molecular mechanism of rotary proton translocation
  • 2015 - 2018 Development of variable-temperature high-speed AFM and its application to temperature-dependent ATPases
  • 2014 - 2018 The interlocked rotation between two rotary molecular motors in ATP synthase VoV1 -The mechanism of intermolecular torque transmission-
  • 2014 - 2016 Measurement of proton pump activity by single molecule of VoV1
Show all
Papers (76)：
  • Taiichi Tsuyama, Ryuga Teramura, Kaoru Mitsuoka, Jun-Ichi Kishikawa, Ken Yokoyama. Cryo-EM structure of the human Pannexin-3 channel. Biochemical and biophysical research communications. 2024. 745. 151227-151227
  • Jun-Ichi Kishikawa, Yui Nishida, Atsuki Nakano, Takayuki Kato, Kaoru Mitsuoka, Kei-Ichi Okazaki, Ken Yokoyama. Rotary mechanism of the prokaryotic Vo motor driven by proton motive force. Nature communications. 2024. 15. 1. 9883-9883
  • Christoph Gerle, Chimari Jiko, Atsuki Nakano, Ken Yokoyama, Chai C Gopalasingam, Hideki Shigematsu, Kazuhiro Abe. Corrigendum to "Human F-ATP synthase as a drug target" [Pharmacol. Res. 209 (2024) 107423]. Pharmacological research. 2024. 209. 107467-107467
  • Christoph Gerle, Chimari Jiko, Atsuki Nakano, Ken Yokoyama, Chai C. Gopalasingam, Hideki Shigematsu, Kazuhiro Abe. Human F-ATP synthase as a drug target. Pharmacological Research. 2024. 209. 107423-107423
  • Atsuki Nakano, Jun-Ichi Kishikawa, Kaoru Mitsuoka, Ken Yokoyama. Mechanism of ATP hydrolysis dependent rotation of bacterial ATP synthase. Nature communications. 2023. 14. 1. 4090-4090
ｍore...
MISC (33)：
  • 岸川 淳一, 中西 温子, 横山 謙. クライオ電子顕微鏡による液胞型ATPase(V0V1)の構造解析. 京都産業大学総合学術研究所所報. 2017. 12. 47-52
  • YOKOYAMA Ken, NAKANISHI Atsuko, KISHIKAWA Jun-ichi. Structural Studies of the Vacuolar type ATPase. 2016. 11. 99-104
  • 遠藤愛子, 遠藤愛子, 牧泰史, 吉田秀司, 横山謙, 古池晶. 回転軸の長さを半分にしたF1-ATPaseの回転とATP加水分解素過程との連動. 日本物理学会講演概要集(CD-ROM). 2016. 71. 1
  • BABA Mihori, NAKANISHI Atsuko, KISHIKAWA Jun-ichi, FURUIKE Shou, YOKOYAMA Ken. Rotor function of flagella protein FliJ in A3B3 of V1-ATPase. 生物物理(Web). 2015. 55. Supplement 1-2
  • NAKANISHI Atsuko, KISHIKAWA Jun-ichi, TAMAKOSHI Masatada, FURUIKE Shou, YOKOYAMA Ken. The ingenious structure of central rotor apparatus in VoV1; torque transmission mechanism in the central rotor of VoV1. 生物物理. 2014. 54. Supplement 1-2 (Web)
ｍore...
Books (4)：
  • タンパク質の構造解析手法とIn silicoスクリーニングへの応用事例
    技術情報協会 2023 ISBN:9784861049712
  • クライオ電子顕微鏡ハンドブック = Handbook of cryo-electron microscopy
    エヌ・ティー・エス 2023 ISBN:9784860438043
  • 膜タンパク質構造研究
    化学同人 2013 ISBN:9784759815610
  • 非侵襲.可視化技術ハンドブック ー ナノ・バイオ 医療から情報システムまで ー
    NTS 2007 ISBN:9784860431334
Lectures and oral presentations  (26)：
  • Structure and Mechanism of V type ATP synthase from Thermus thermophilus.
    (International Symposium “50th anniversary of Thermus thermophilus discovery” 2018)
  • Cryo EM structure of V type ATP synthase from Thermus thermophilus.
    (2018)
  • Cryo EM structure of V type ATP synthase from Thermus thermophilus.
    (2018)
  • Structural analysis of membrane protein complex by cryoEM.
    (2018)
  • ATP合成活性を阻害して寿命伸長をもたらす物質の探索
    (生命科学系学会合同年次大会 2017)
ｍore...
Education (3)：
  • - 1991 東京工業大学大学院 総合理工学研究科 生命化学専攻
  • - 1991 Tokyo Institute of Technology Graduate School, Division of Integrated Science and Engineering
  • - 1986 Shizuoka University Faculty of Science
Work history (3)：
  • Kyoto Sangyo University Faculty of Life Sciences
  • 科学振興機構 ERATO-ICORP project GL
  • Kanazawa University Faculty of Pharmaceutical Sciences
Committee career (2)：
  • - 現在 日本生体エネルギー研究会 常任幹事
  • - 現在 日本生物物理学会 分野別専門委員
Association Membership(s) (3)：
日本生物物理学会 ,  日本分子生物学会 ,  日本生化学会
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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