KEN YOKOYAMA

Research field (4)： Functional biochemistry , Biophysics , Cell biology , Structural biochemistry

Research keywords (9)： sensor protein , FoF1 , F1 , rotary molecular motor , ATP synthase , CryoEM , ATP , 生体エネルギー , V-ATPase

Research theme for competitive and other funds (23)：

2020 - 2023 クライオ電子顕微鏡による V型ATPaseの回転機構の解明
2017 - 2020 Structural analysis for vacuolar type ATPase to reveal molecular mechanism of rotary proton translocation
2015 - 2018 Development of variable-temperature high-speed AFM and its application to temperature-dependent ATPases
2014 - 2018 The interlocked rotation between two rotary molecular motors in ATP synthase VoV1 -The mechanism of intermolecular torque transmission-
2014 - 2016 Measurement of proton pump activity by single molecule of VoV1

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Papers (74)：

Christoph Gerle, Chimari Jiko, Atsuki Nakano, Ken Yokoyama, Chai C Gopalasingam, Hideki Shigematsu, Kazuhiro Abe. Corrigendum to "Human F-ATP synthase as a drug target" [Pharmacol. Res. 209 (2024) 107423]. Pharmacological research. 2024. 209. 107467-107467
Christoph Gerle, Chimari Jiko, Atsuki Nakano, Ken Yokoyama, Chai C. Gopalasingam, Hideki Shigematsu, Kazuhiro Abe. Human F-ATP synthase as a drug target. Pharmacological Research. 2024. 209. 107423-107423
Atsuki Nakano, Jun-Ichi Kishikawa, Kaoru Mitsuoka, Ken Yokoyama. Mechanism of ATP hydrolysis dependent rotation of bacterial ATP synthase. Nature communications. 2023. 14. 1. 4090-4090
Ken Yokoyama. Rotary mechanism of V/A-ATPases-how is ATP hydrolysis converted into a mechanical step rotation in rotary ATPases?. Frontiers in Molecular Biosciences. 2023. 10
Atsuko Nakanishi, Jun-Ichi Kishikawa, Kaoru Mitsuoka, Ken Yokoyama. Cryo-EM analysis of V/A-ATPase intermediates reveals the transition of the ground-state structure to steady-state structures by sequential ATP binding. The Journal of biological chemistry. 2023. 102884-102884

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MISC (33)：

岸川淳一, 中西温子, 横山謙. クライオ電子顕微鏡による液胞型ATPase(V0V1)の構造解析. 京都産業大学総合学術研究所所報. 2017. 12. 47-52
YOKOYAMA Ken, NAKANISHI Atsuko, KISHIKAWA Jun-ichi. Structural Studies of the Vacuolar type ATPase. 2016. 11. 99-104
遠藤愛子, 遠藤愛子, 牧泰史, 吉田秀司, 横山謙, 古池晶. 回転軸の長さを半分にしたF1-ATPaseの回転とATP加水分解素過程との連動. 日本物理学会講演概要集(CD-ROM). 2016. 71. 1
BABA Mihori, NAKANISHI Atsuko, KISHIKAWA Jun-ichi, FURUIKE Shou, YOKOYAMA Ken. Rotor function of flagella protein FliJ in A3B3 of V1-ATPase. 生物物理(Web). 2015. 55. Supplement 1-2
NAKANISHI Atsuko, KISHIKAWA Jun-ichi, TAMAKOSHI Masatada, FURUIKE Shou, YOKOYAMA Ken. The ingenious structure of central rotor apparatus in V_oV₁; torque transmission mechanism in the central rotor of V_oV₁. 生物物理. 2014. 54. Supplement 1-2 (Web)

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Books (4)：

タンパク質の構造解析手法とIn silicoスクリーニングへの応用事例
技術情報協会 2023 ISBN:9784861049712
クライオ電子顕微鏡ハンドブック = Handbook of cryo-electron microscopy
エヌ・ティー・エス 2023 ISBN:9784860438043
膜タンパク質構造研究
化学同人 2013 ISBN:9784759815610
非侵襲.可視化技術ハンドブックーナノ・バイオ医療から情報システムまでー
NTS 2007 ISBN:9784860431334

Lectures and oral presentations (26)：

Structure and Mechanism of V type ATP synthase from Thermus thermophilus.
(International Symposium “50th anniversary of Thermus thermophilus discovery” 2018)
Cryo EM structure of V type ATP synthase from Thermus thermophilus.
(2018)
Cryo EM structure of V type ATP synthase from Thermus thermophilus.
(2018)
Structural analysis of membrane protein complex by cryoEM.
(2018)
ATP合成活性を阻害して寿命伸長をもたらす物質の探索
(生命科学系学会合同年次大会 2017)

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Education (3)：

- 1991 東京工業大学大学院総合理工学研究科生命化学専攻
- 1991 Tokyo Institute of Technology Graduate School, Division of Integrated Science and Engineering
- 1986 Shizuoka University Faculty of Science

Work history (3)：

Committee career (2)：

Association Membership(s) (3)：

日本生物物理学会 , 日本分子生物学会 , 日本生化学会

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