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J-GLOBAL ID：201001034827173780   Update date: Mar. 15, 2025

Machida Takashi

マチダ タカシ | Machida Takashi
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Affiliation and department：
Kurume University School of Medicine School of Medicine

About Kurume University School of Medicine School of Medicine


Job title： Assistant Professor
Research field  (3)： Pharmacology ,  Pharmaceuticals - health and biochemistry ,  Clinical pharmacy
Research keywords  (1)： 血液脳関門
Papers (7)：
  • Takata F, Dohgu S, Matsumoto J, Machida T, Sakaguchi S, Kimura I, Yamauchi A, Kataoka Y. Oncostatin M-induced blood-brain barrier impairment is due to prolonged activation of STAT3 signaling in vitro. J Cell Biochem. 2018. 119. 11. 9055-9063
  • Matsumoto J, Dohgu S, Takata F, Machida T, Hatip FFB, Hatip-Al-Khatib I, Yamauchi A, Kataoka Y. TNF-alpha-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between IkappaB-NFkappaB and JAK-STAT3 pathways. Brain Res. 2018. 1692. 34-44
  • Takashi Machida, Shinya Dohgu, Fuyuko Takata, Junichi Matsumoto, Ikuya Kimura, Mariko Koga, Keiko Nakamoto, Atsushi Yamauchi, Yasufumi Kataoka. ROLE OF THROMBIN-PAR1-PKC theta/delta AXIS IN BRAIN PERICYTES IN THROMBIN-INDUCED MMP-9 PRODUCTION AND BLOOD-BRAIN BARRIER DYSFUNCTION IN VITRO. NEUROSCIENCE. 2017. 350. 146-157
  • Takashi Machida, Fuyuko Takata, Junichi Matsumoto, Tomoyuki Miyamura, Ryosuke Hirata, Ikuya Kimura, Yasufumi Kataoka, Shinya Dohgu, Atsushi Yamauchi. Contribution of thrombin-reactive brain pericytes to blood-brain barrier dysfunction in an in vivo mouse model of obesity-associated diabetes and an in vitro rat model. PLOS ONE. 2017. 12. 5
  • Machida T, Takata F, Matsumoto J, Takenoshita H, Kimura I, Yamauchi A, Dohgu S, Kataoka Y. Brain pericytes are the most thrombin-sensitive matrix metalloproteinase-9-releasing cell type constituting the blood-brain barrier in vitro. Neurosci Lett. 2015. 599. 109-114
ｍore...
MISC (27)：
ｍore...
Lectures and oral presentations  (18)：
  • Adenosine stimulates brain pericytes to release matrix metalloproteinase-9 through A3 adenosine receptor
    (第86回日本薬理学会年 2013)
  • Alpha7 nicotinic acetylcholine receptor mediates MMP-9 release from brain pericytes
    (第86回日本薬理学会年 2013)
  • Brain pericytes contribute to the blood-brain barrier disruption induced by thrombin
    (第86回日本薬理学会年 2013)
  • Adenosine stimulates brain pericytes to release matrix metalloproteinase-9 through A3 adenosine receptor
    (第86回日本薬理学会年 2013)
  • Alpha7 nicotinic acetylcholine receptor mediates MMP-9 release from brain pericytes
    (第86回日本薬理学会年 2013)
ｍore...
Education (2)：
  • - 2010 Fukuoka University Division of Pharmaceutical Sciences
  • - 2010 Fukuoka University Graduate School, Division of Pharmaceutical Sciences
Professional career (4)：
  • 学士(芸術工学)
  • 学士(薬学)
  • Ph.D. (Fukuoka University)
  • 学士(医学) (鹿児島大学)
Work history (2)：
  • 久留米大学 救急医学講座 助教
  • Fukuoka University Faculty of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences
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