Research theme for competitive and other funds (11):
2016 - 2018 タンパク質を基盤とした酸素濃度イメージングプローブの創製
2013 - 2018 分子機能を生み出す柔らかさの時間分解観測とその発現機構解明
2012 - 2014 結晶化触媒酵素の分子機構
2011 - 2012 Technical development of selective observation of proteins inliving cells by using ultraviolet resonance Raman spectroscopy
2010 - 2011 Reaction Mechanism of Heme Detoxification Enzyme
2007 - 2011 Elucidation of structural basis of dynamically-driven protein allostery by time-resolved resonance Raman spectroscopy
2009 - 2010 ヘム結晶化の分子機構解明
2003 - 2005 酸化修飾による蛋白質制御メカニズムの解析-ユビキチン系をモデルとして-
1999 - 2001 新規DNA結合タンパク質COOAを用いた転写調節機構の解明
Structural and Fanctional Characterization of Metal Sensor Proteins
Studies on the Molecular Regulation Mechanisms of Ligand Binding in Heme Proteins
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Papers (58):
Xiang Gao, Haruto Ishikawa, Misao Mizuno, Yasuhisa Mizutani. Cooperative Protein Dynamics of Heterotetrameric Hemoglobin from Scapharca inaequivalvis. The Journal of Physical Chemistry B. 2024
Xiang Gao, Misao Mizuno, Haruto Ishikawa, Srinivasan Muniyappan, Hyotcherl Ihee, Yasuhisa Mizutani. Structural dynamics of the heme pocket and intersubunit coupling in the dimeric hemoglobin from Scapharca inaequivalvis. The Journal of Chemical Physics. 2024
Yu Iritani, Haruto Ishikawa, Misao Mizuno, Yasuhisa Mizutani. Heme Pocket Structure and Its Functional Implications in an Ancestral Globin Protein. Biochemistry. 2023. 62. 18. 2727-2737
Takeo Yamawaki, Misao Mizuno, Haruto Ishikawa, Kazuhiro Takemura, Akio Kitao, Yoshitsugu Shiro, Yasuhisa Mizutani. Regulatory Switching by Concerted Motions on the Microsecond Time Scale of the Oxygen Sensor Protein FixL. The Journal of Physical Chemistry B. 2021. 125. 25. 6847-6856
A. Otomo, H. Ishikawa, M. Mizuno, Y. Mizutani, S. Aono. Structural changes in the heme and heme pocket upon CO dissociation of CooA observed by time-resolved resonance Raman spectroscopy. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY. 2014. 19. S287-S287
H. Ishikawa, K. Nakatani, Y. Mizutani, S. Aono. Identification of active-site residues in heme detoxification protein. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY. 2014. 19. S284-S284