Takei Kohtaro

タケイコウタロウ | Takei Kohtaro

Affiliation and department：
Homepage URL (1)： http://yokohama-cu-mbs-lotus.jp/

Research field (3)： Clinical pharmacy , Physiology , Neuroscience - general

Research keywords (16)：健忘症 , 脳梗塞 , 脊髄損傷 , 神経修復 , Nogo receptor , Lateral olfactory usher substance (LOTUS) , Chromophore-assisted light inactivation , Nerve growth cone , Neurite outgrowth , Axon guidance , Chromophore-assisted light inactivation (CALI) , Brain・Neuron , Axonal growth , Neural development , Neural circuit formation , Neuronal regeneration

Research theme for competitive and other funds (17)：

2021 - 2023 Induction of neural plasticity by Nogo receptor antagonist LOTUS in aged brain
2020 - 2023 Development of neural regeneration therapy by gene transfection of neuronal circuit formation factor LOTUS
2020 - 2022 Development of therapy basis for dementia by using neural circuit formation factor LOTUS
2017 - 2020 Development of medical technology for neuronal regeneration by using LOTUS protein
2016 - 2018 Regulation of axon growth by molecular interaction between neuron and oligodendrocyte

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Papers (52)：

Takuya Ikeda, Keita Takahashi, Minatsu Higashi, Hiroyasu Komiya, Tetsuya Asano, Akihiro Ogasawara, Shun Kubota, Shunta Hashiguchi, Misako Kunii, Kenichi Tanaka, et al. Lateral olfactory tract usher substance (LOTUS), an endogenous Nogo receptor antagonist, ameliorates disease progression in amyotrophic lateral sclerosis model mice. Cell death discovery. 2023. 9. 1. 454-454
Junpei Matsubayashi, Yuki Kawaguchi, Yutaka Kawakami, Kohtaro Takei. Brain-derived neurotrophic factor (BDNF) induces antagonistic action to Nogo signaling by the upregulation of lateral olfactory tract usher substance (LOTUS) expression. Journal of neurochemistry. 2023. 164. 1. 29-43
Yuki Kawaguchi, Junpei Matsubayashi, Yutaka Kawakami, Ryohei Nishida, Yuji Kurihara, Kohtaro Takei. LOTUS suppresses amyloid β-induced dendritic spine elimination through the blockade of amyloid β binding to PirB. Molecular medicine (Cambridge, Mass.). 2022. 28. 1. 154-154
Ryohei Nishida, Yuki Kawaguchi, Junpei Matsubayashi, Rie Ishikawa, Satoshi Kida, Kohtaro Takei. LOTUS, an endogenous Nogo receptor antagonist, is involved in synapse and memory formation. Scientific Reports. 2021. 11. 1. 5085-5085
Ito, S, Nagoshi, N, Kamata, Y, Kojima, K, Nori, S, Matsumoto, M, Takei, K, Nakamura, M, Okano, H. LOTUS overexpression via ex vivo gene transduction further promotes recovery of motor function following human iPSC-NS/PC transplantation for contusive spinal cord injury. Stem Cell Reports. 2021. 16. 11. 1-15

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MISC (8)：

Keita Takahashi, Kohtaro Takei, Fumiaki Tanaka. Association of multiple sclerosis with lateral olfactory tract usher substance (LOTUS), a possible endogenous inhibitor of axonal degeneration. Clinical and Experimental Neuroimmunology. 2015. 6. 64-69
Yuji Kurihara, Kohtaro Takei. LOTUS, a potent blocker of Nogo receptor-1 causing inhibition of axonal growth. NEURAL REGENERATION RESEARCH. 2015. 10. 1. 46-48
Yusuke Kobayashi, Nobuhito Hirawa, Yasuharu Tabara, Hidenori Muraoka, Megumi Fujita, Nobuko Miyazaki, Akira Fujiwara, Yasuhiro Ichikawa, Yuichiro Yamamoto, Naoaki Ichihara, et al. Mice lacking hypertension candidate gene ATP2B1 in vascular smooth muscle cells show significant blood pressure elevation. Hypertension. 2012. 59. 4. 854-860
栗原裕司, 池谷真澄, 伊藤拓夢, 西山邦幸, 榊原裕介, 中村史雄, 水木信久, 五嶋良郎, 竹居光太郎. 内在性Nogo66受容体アンタゴニストLOTUSの機能ドメイン検索(Functional domain of LOTUS serving as endogenous Nogo66 receptor antagonist). 神経化学. 2011. 50. 2-3. 170-170
栗原裕司, 有江裕子, 山口めぐみ, 池谷真澄, 中村史雄, 水木信久, 五嶋良郎, 竹居光太郎. 新規軸索ガイダンス分子LOTUSとNogo-66受容体との結合による神経突起伸長作用(Neurite outgrowth promoting effect of a novel axon guidance molecule LOTUS through binding to Nogo-66 receptor). 神経化学. 2009. 48. 2-3. 197-197

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Lectures and oral presentations (3)：

神経再生阻害因子の制御分子LOTUSによる神経損傷の修復
(第40回神経組織培養研究会 2018)
神経回路形成因子LOTUSによる脳内環境制御
(2018年度生理学研究所研究会「神経発達・再生研究会」 2018)
内在性Nogo受容体アンタゴニストLOTUSの神経再生医療への適用
(第61回日本神経化学会, 2018)

Education (1)：

1982 - 1988 The University of Tokyo Graduate School of Sciences Biological Sciences (Zoological Sciences)

Professional career (1)：

Doctor of Science (The University of Tokyo)

Work history (8)：

2024/02 - 現在 Yokohama City University Grafuate School of Medicine
2013/04 - Yokohama City University School of Medicine (Graduate School of Medical Life Science) Professor
2002/12 - 2013/03 Yokohama City University School of Medicine Associate Professor
2001 - 2002/11 Toho University School of Medicine Assistant Professor
1995/10 - 2000/09 JST ERATO Research group leader

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Committee career (7)：

2020/04 - 現在日本神経化学会副理事長
2019/04 - 現在日本神経化学会倫理委員会
2019/04 - 現在日本神経化学会若手育成委員会
2019 - 現在日本神経化学会利益相反委員会
2018/04 - 現在日本神経化学会理事

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Awards (3)：

2013/12 - Yokohama Medical Association Umehara award
2013/06 - Cosmo Bio Co. Ltd. Article of the year
2012/10 - Yokohama Medical Association Award of Yokohama Medical Association

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