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J-GLOBAL ID：201101009167397160 Update date: Apr. 23, 2025

Takei Kohtaro

タケイコウタロウ | Takei Kohtaro

Affiliation and department：
Homepage URL (1)： http://yokohama-cu-mbs-lotus.jp/

Research field (3)： Clinical pharmacy , Physiology , Neuroscience - general

Research keywords (19)：神経バイオマーカー , アルツハイマー型認知症 , Synapse formation , 健忘症 , 脳梗塞 , 脊髄損傷 , 神経修復 , Nogo receptor , Lateral olfactory usher substance (LOTUS) , Chromophore-assisted light inactivation , Nerve growth cone , Neurite outgrowth , Axon guidance , Chromophore-assisted light inactivation (CALI) , Brain・Neuron , Axonal growth , Neural development , Neural circuit formation , Neuronal regeneration

Research theme for competitive and other funds (21)：

2024 - 2026 神経再生促進因子LOTUSによるアルツハイマー型認知症に対する病態改善効果の検討
2023 - 2026 神経再生促進因子LOTUSによるアルツハイマー型認知症に対する病態改善効果の検討
2023 - 2025 Nogo受容体アンタゴニストLOTUSによる老齢期における神経可塑性誘導
2021 - 2023 Induction of neural plasticity by Nogo receptor antagonist LOTUS in aged brain
2020 - 2023 Development of neural regeneration therapy by gene transfection of neuronal circuit formation factor LOTUS

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Papers (54)：

Yuji Kurihara, Yuki Kawaguchi, Yuki Ohta, Nana Kawasaki, Yuki Fujita, Kohtaro Takei. Nogo Receptor Antagonist LOTUS Promotes Neurite Outgrowth through Its Interaction with Teneurin-4. Cells. 2024. 13. 16. 1369-1369
Takuya Ikeda, Keita Takahashi, Minatsu Higashi, Hiroyasu Komiya, Tetsuya Asano, Akihiro Ogasawara, Shun Kubota, Shunta Hashiguchi, Misako Kunii, Kenichi Tanaka, et al. Lateral olfactory tract usher substance (LOTUS), an endogenous Nogo receptor antagonist, ameliorates disease progression in amyotrophic lateral sclerosis model mice. Cell Death Discovery. 2023. 9. 1. 454-454
Junpei Matsubayashi, Yuki Kawaguchi, Yutaka Kawakami, Kohtaro Takei. Brain-derived neurotrophic factor (BDNF) induces antagonistic action to Nogo signaling by the upregulation of lateral olfactory tract usher substance (LOTUS) expression. Journal of Neurochemistry. 2023. 164. 1. 29-43
Yuki Kawaguchi, Junpei Matsubayashi, Yutaka Kawakami, Ryohei Nishida, Yuji Kurihara, Kohtaro Takei. LOTUS suppresses amyloid β-induced dendritic spine elimination through the blockade of amyloid β binding to PirB. Molecular Medicine (Cambridge, Mass.). 2022. 28. 1. 154-154
Ryohei Nishida, Yuki Kawaguchi, Junpei Matsubayashi, Rie Ishikawa, Satoshi Kida, Kohtaro Takei. LOTUS, an endogenous Nogo receptor antagonist, is involved in synapse and memory formation. Scientific Reports. 2021. 11. 1. 5085-5085

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MISC (17)：

KAWAGUCHI Yuki, KAWAGUCHI Yuki, NISHIDA Ryohei, MATSUBAYASHI Junpei, MATSUBAYASHI Junpei, TAKEI Kohtaro, TAKEI Kohtaro. Induction of synaptic plasticity by a neural circuit formation factor LOTUS. 日本神経化学会大会抄録集(Web). 2023. 66th
川上裕, 川上裕, 松林潤平, 川口祐生, 竹居光太郎. 中枢神経系における内因性神経回路形成因子LOTUSの抑制性発現制御機構の検証. 日本神経化学会大会抄録集(Web). 2022. 65th
MATSUBAYASHI Junpei, KAWAGUCHI Yuki, TAKEI Kohtaro. Expression of LOTUS, a neural circuit formation factor, is increased by BDNF. 日本神経化学会大会抄録集(Web). 2021. 64th
KAWAGUCHI Yuki, KURIHARA Yuji, MATUSBAYASHISHI Junpei, KAWAKAMI Yutaka, TAKEI Kohtaro. Regulation of PirB, an amyloid β protein receptor by a neural circuit formation factor LOTUS. 日本神経化学会大会抄録集(Web). 2021. 64th
Keita Takahashi, Kohtaro Takei, Fumiaki Tanaka. Association of multiple sclerosis with lateral olfactory tract usher substance (LOTUS), a possible endogenous inhibitor of axonal degeneration. Clinical and Experimental Neuroimmunology. 2015. 6. 64-69

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Lectures and oral presentations (3)：

神経再生阻害因子の制御分子LOTUSによる神経損傷の修復
(第40回神経組織培養研究会 2018)
神経回路形成因子LOTUSによる脳内環境制御
(2018年度生理学研究所研究会「神経発達・再生研究会」 2018)
内在性Nogo受容体アンタゴニストLOTUSの神経再生医療への適用
(第61回日本神経化学会, 2018)

Education (1)：

1982 - 1988 The University of Tokyo Graduate School of Sciences Biological Sciences (Zoological Sciences)

Professional career (1)：

Doctor of Science (The University of Tokyo)

Work history (8)：

2024/02 - 現在 Yokohama City University Grafuate School of Medicine
2013/04 - Yokohama City University School of Medicine (Graduate School of Medical Life Science) Professor
2002/12 - 2013/03 Yokohama City University School of Medicine Associate Professor
2001 - 2002/11 Toho University School of Medicine Assistant Professor
1995/10 - 2000/09 JST ERATO Research group leader

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Committee career (8)：

2023/04 - 現在日本神経化学会学会史編纂委員会・委員長
2020/04 - 現在日本神経化学会副理事長
2019/04 - 現在日本神経化学会倫理委員会
2019/04 - 現在日本神経化学会若手育成委員会
2019 - 現在日本神経化学会利益相反委員会

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Awards (3)：

2013/12 - Yokohama Medical Association Umehara award
2013/06 - Cosmo Bio Co. Ltd. Article of the year
2012/10 - Yokohama Medical Association Award of Yokohama Medical Association

Association Membership(s) (1)：

日本再生医療学会

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